Migraine and sleep disorders: a systematic review

Tiseo, Cindy; Vacca, Alessandro; Felbush, Anton; Филимонова, Т. А.; Gai, Annalisa; Glazyrina, Tatyana; Hubalek, Irina Anna; Marchenko, Yelena; Overeem, Lucas Hendrik; Piroso, S.; Tkachev, Alexander; Martelletti, Paolo; Sacco, Simona

doi:10.1186/s10194-020-01192-5

Cited by 144 publications

(151 citation statements)

References 125 publications

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“…In this respect, patients with migraine, especially older men with chronic migraine and a high BMI, seem to have a high risk of sleep apnea, whose treatment (e.g., with an oral appliance) might be beneficial in some patients ( 160 , 161 ). To date, the causal relationship between obstructive sleep apnea and migraine has not been established, although this sleep disturbance may be a trigger factor that could accelerate migraine progression ( 162 ). Moreover, it has been suggested that migraine attacks are related to chronobiological mechanisms that are involved in the triggering and onset of migraine attacks ( 163 ), which might be related to individual chronotypes ( 164 ).…”

Section: Association Of Migraine and Obesitymentioning

confidence: 99%

Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus

et al. 2021

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Migraine is a disabling neurovascular disorder, characterized by moderate to severe unilateral headaches, nausea, photophobia, and/or phonophobia, with a higher prevalence in women than in men, which can drastically affect the quality of life of migraine patients. In addition, this chronic disorder is related with metabolic comorbidities associated with the patient's lifestyle, including obesity and diabetes mellitus (DM). Beyond the personal and socioeconomic impact caused by migraine, obesity and DM, it has been suggested that these metabolic disorders seem to be related to migraine since: (i) they are a risk factor for developing cardiovascular disorders or chronic diseases; (ii) they can be influenced by genetic and environmental risk factors; and (iii) while clinical and epidemiological studies suggest that obesity is a risk factor for migraine, DM (i.e., type 1 and type 2 DM) have been reported to be either a protective or a risk factor in migraine. On this basis, and given the high worldwide prevalence of migraine, obesity, and DM, this article provides a narrative review of the current literature related to the association between the etiology and pathophysiology of migraine and these metabolic disorders, considering lifestyle aspects, as well as the possible involvement of neurotransmitters, neuropeptides, and/or sex hormones. While a link between migraine and metabolic disorders has been suggested, many studies are contradictory and the mechanisms involved in this association are not yet sufficiently established. Therefore, further research should be focused on understanding the possible mechanisms involved.

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Section: Association Of Migraine and Obesitymentioning

confidence: 99%

Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus

et al. 2021

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“…Extensive research has recognized an association between primary headache and various comorbidities, as shown in some literature reviews [3,[5][6][7][8][9][10]. Comorbidities of primary headache disorders, include neurological, metabolic and cardiovascular conditions, e.g.…”

Section: Introductionmentioning

confidence: 99%

Comorbidities of primary headache disorders: a literature review with meta-analysis

Caponnetto

Deodato

Robotti³

et al. 2021

J Headache Pain

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Background Primary headache disorders are common and burdensome conditions. They are associated to several comorbidities, such as cardiovascular or psychiatric ones, which, in turn, contribute to the global burden of headache. The aim of this study is to provide a comprehensive description of the pooled prevalence of comorbidities of primary headache disorders using a meta-analytical approach based on studies published between 2000 and 2020. Methods Scopus was searched for primary research (clinical and population studies) in which medical comorbidities were described in adults with primary headache disorders. Comorbidities were extracted using a taxonomy derived from the Global Burden of Disease (GBD) study. We compared prevalence of comorbidities among headache sufferers against general population using GBD-2019 estimates, and compared comorbidities’ proportions in clinical vs. population studies, and by age and gender. Results A total of 139 studies reporting information on 4.19 million subjects with primary headaches were included: in total 2.75 million comorbidities were reported (median per subject 0.64, interquartile range 0.32–1.07). The most frequently addressed comorbidities were: depressive disorders, addressed in 51 studies (pooled proportion 23 %, 95 % CI 20–26 %); hypertension, addressed in 48 studies (pooled proportion 24 %, 95 % CI 22–26 %); anxiety disorders addressed in 40 studies (pooled proportion 25 %, 95 % CI 22–28 %). For conditions such as anxiety, depression and back pain, prevalence among headache sufferers was higher than in GBD-2109 estimates. Associations with average age and female prevalence within studies showed that hypertension was more frequent in studies with higher age and less females, whereas fibromyalgia, restless leg syndrome, and depressive disorders were more frequent in studies with younger age and more female. Conclusions Some of the most relevant comorbidities of primary headache disorders – back pain, anxiety and depression, diabetes, ischemic heart disease and stroke – are among the most burdensome conditions, together with headache themselves, according to the GBD study. A joint treatment of headaches and of these comorbidities may positively impact on headache sufferers’ health status and contribute to reduce the impact of a group of highly burdensome diseases.

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“…Sleep problems are commonly reported in association with migraine disorders (39), with higher frequency of migraine attacks (40) and chronic migraine (41) being associated with poor sleep quality. Shared nervous system pathways involved in sleep cycle dysregulation and migraine pathophysiology may underlie the association between migraine and sleep disorders (39). There is an increased incidence of sleep disorders among women during perimenopause.…”

Section: Discussionmentioning

confidence: 99%

Allostatic Load in Perimenopausal Women With Migraine

Alebna

Maleki

2021

Front. Neurol.

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Objective: There is very limited data on women with migraine disease as they age and transition to menopause. Despite evidence for the increased burden of the disease during this transition, there is no data on the association between migraine and allostatic load as a marker of cumulative biological risk. We aimed to determine whether women with migraine suffer from higher levels of allostatic load during perimenopausal transition.Methods: A total of 2,105 perimenopausal women from the first wave of the Study of Women's Health Across the Nation (SWAN) were included in this study. Allostatic Load (AL) score was estimated for each participant from the measurements of: systolic and diastolic blood pressure, C-reactive protein level, high-density lipoprotein cholesterol level, total cholesterol level, waist-to-hip ratio, fasting serum glucose, triglycerides, and dehydroepiandrosterone levels.Results: Of the 2,105 participants included in the study, there were 369 migraineurs and 1,730 controls. Migraineurs had 63% higher odds of increased load score (odds ratio 1.63; 95% confidence interval, 1.17–2.29). Compared to controls, migraineurs were more likely to experience sleep problems in the univariate analysis, however despite the high burden of sleep problems, there were no significant associations between allostatic load and sleep disturbances in perimenopausal women with migraine after controlling for other factors.Conclusion: This is the first study to systematically and quantitatively examine allostatic load in migraine patients. The findings establish that migraineurs are more likely to experience higher allostatic load than their non-migraine counterparts during perimenopausal transition. The findings encourage new lines of investigation for lowering the burden of the disease through interventions that modify the levels of allostatic load biomarkers examined in this study.

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Migraine and sleep disorders: a systematic review

Cited by 144 publications

References 125 publications

Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus

Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus

Comorbidities of primary headache disorders: a literature review with meta-analysis

Allostatic Load in Perimenopausal Women With Migraine

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