Circadian Variation in the Efficacy of Tissue-Type Plasminogen Activator

Kurnik, Peter B.

doi:10.1161/01.cir.91.5.1341

Cited by 113 publications

(60 citation statements)

References 22 publications

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“…22) Enhanced secretion of PAI-1 may contribute to both the increased incidence of acute atherothrombotic events and the decreased efficacy of thrombolytic therapy. 23) The levels of adiponectin exhibit a diurnal rhythm with a significant decline at night in healthy men. 24) Conversely, serum levels of adiponectin are diminished in humans and animals with insulin resistance and obesity.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Circadian Gene Expressions in Mice White Adipose Tissue and 3T3-L1 Adipocytes

Aoyagi

Shimba

Tezuka

2005

JOURNAL OF HEALTH SCIENCE

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Most, if not all, of physiological and behavioral processes exhibit circadian rhythms. Recently, molecular clocks similar to those operating in the suprachiasmatic nucleus (SCN) neurons have been found in several peripheral tissues. Among peripheral tissues, several recent studies have revealed that white adipose tissues secrete a number of biologically active molecules such as leptin, resistin, adiponectin, etc. Importantly, the levels of these cytokine-like molecules are associated with development of lifestyle-related diseases such as diabetic mellitus, cardiovascular diseases, and obesity. In this study, we attempted to characterize circadian gene expression in adipose tissue. Here, we show that the expression of several clock genes exhibits daily oscillation in mice white adipocytes. Circadian expression of adipocytes-related genes such as peroxisome proliferator-activated receptor (PPAR) γ2 was also observed. Interestingly, expression pattern of some clock genes in adipocytes is distinct from that in stromal-vascular fractions containing preadipocytes. In addition to these in vivo studies, we demonstrated that serum-or dexamethasone-shock induced the cyclic gene expression of clock genes in cultured adipocytes. Consequently, we are led to conclude that adipocytes contain the machineries necessary for circadian oscillation similar to that found in SCN. We then examined that whether the pharmacological effects of PPARγ2 ligand depend on the time of administration. Consist with its receptor levels, the pharmacological effects of PPARγ ligand administered during a dark period were more efficient than those during a light period in mice. These results suggest that chronotherapy targeted for adipocyte functions could be effective in improving of the symptoms of hyperlipidemia and other related diseases.

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Section: Introductionmentioning

confidence: 99%

Characteristics of Circadian Gene Expressions in Mice White Adipose Tissue and 3T3-L1 Adipocytes

Aoyagi

Shimba

Tezuka

2005

JOURNAL OF HEALTH SCIENCE

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“…In fact, t-PA seems to be more effective particularly during diurnal hours, whereas a higher resistance to thrombolysis in the early morning, associated with plasminogen activator inhibitor-1 level increase, has been reported. 12,[35][36][37] This has also been suggested by a significant difference in the proportion of diurnal and nocturnal early recanalization 2 hours after t-PA bolus. 24 In the SITS cohort, data on early recanalization are not available, whereas we found the same proportion of reversal of the HMCAS, a surrogate marker of recanalization, 38 22 to 36 hours after diurnal or nocturnal treatment.…”

Section: Discussionmentioning

confidence: 77%

“…[1][2][3][4][5][6] An increased incidence of stroke has been reported during the weekend and on Monday, 3,7,8 whereas other studies reported Wednesday as the most risky day; and others did not find significant variations among the days of the week. [9][10][11] Circadian changes of biological hemodynamic and hemostatic processes, including a reduction of fibrinolytic activity with increased thrombogenic condition in the late-morning hours 12 and on weekends, 13 have been advocated to explain temporal variations of stroke onset.…”

mentioning

confidence: 99%

Within-Day and Weekly Variations of Thrombolysis in Acute Ischemic Stroke

Lorenzano

Ahmed

Tatlısumak

et al. 2014

Stroke

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For each subgroup, we analyzed frequency of thrombolytic treatments, time intervals, and outcomes (3-month modified Rankin Scale score 0-2 as good functional outcome, mortality, symptomatic intracerebral hemorrhage). Results-We included 21 513 patients. Considering the mean expected number of patients treated per hour (0.4) and per day of the week (9.8), if no temporal variations were present, patients were significantly treated more during day hours and weekdays (P<0.0001). Median door-to-needle and onset-to-treatment times were longer for patients treated during night hours and on weekends (P<0.01). After adjustment for confounding variables, treatment during day hours was an independent predictor of good functional outcome (odds ratio, 1.12; 95% confidence interval, 1.04-1.21; P=0.004), and patients treated during weekdays were at risk of higher mortality (odds ratio, 1.15; 95% confidence interval, 1.04-1.28; P=0.008). Conclusions-Frequency of thrombolytic treatment seems to follow the same circadian pattern of stroke incidence, whereas its correspondence to a weekly pattern is less clear. Time of treatment is an independent predictor of outcome. (Stroke. 2014;45:176-184.)

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“…136 Indeed, a high level of tissue plasminogen activator inhibitor 1, associated with low fibrinolytic activity, was found to be an independent risk factor for first acute MI in both men and women. 137 The combination of increased platelet aggregability, 138 blood viscosity, 139 and thrombotic activity, 19 as well as decreased fibrinolytic activity, 135,[140][141][142] would not only increase the size of an otherwise nonoccluding thrombus but would also increase its resistance to thrombolysis. …”

Section: Other Hematologic Factorsmentioning

confidence: 99%

Circadian rhythm and cardiovascular disorders

Zhang¹,

Sabeh²,

Jain³

2014

CPT

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Abstract:Circadian rhythmicity affects all living organisms on earth. Central and peripheral cellular clocks have the ability to oscillate and be entrained to environmental cues, thus allowing organisms to anticipate and synchronize their physiologic processes and behavior to recurring daily environmental alterations. Disruption of the circadian rhythm in modern life, such as by shift work and jet travel, leads to dyssynchrony of the central and peripheral clocks, and is an independent risk factor for cardiovascular disease and the metabolic syndrome. Aging has also been associated with attenuated cellular rhythmicity. Here we summarize the clinical observations linking cardiovascular health to circadian rhythm. In addition, we discuss recent advances in experimental models for understanding the clock machinery in terms of a variety of physiologic processes within the cardiovascular system. Together, these studies build the foundation for applying our knowledge of circadian biology to the development of novel therapy for cardiovascular disorders.

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Circadian Variation in the Efficacy of Tissue-Type Plasminogen Activator

Cited by 113 publications

References 22 publications

Characteristics of Circadian Gene Expressions in Mice White Adipose Tissue and 3T3-L1 Adipocytes

Characteristics of Circadian Gene Expressions in Mice White Adipose Tissue and 3T3-L1 Adipocytes

Within-Day and Weekly Variations of Thrombolysis in Acute Ischemic Stroke

Circadian rhythm and cardiovascular disorders

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