Circadian variation in oxidative stress markers in healthy and type II diabetic men

Kanabrocki, Eugene L.; Murray, Dennis; Hermida, Ramón C.; Scott, G.; Bremner, W. F.; Ryan, M.; Ayala, Diana E.; Third, Jane L.H.C.; Shirazi, Parvez; Nemchausky, Bernard A.; Hooper, D. Craig

doi:10.1081/cbi-120002914

Cited by 108 publications

(85 citation statements)

References 26 publications

(34 reference statements)

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“…A study by Kanabrocki et al found that many byproducts of an increase in oxidative stress are regulated rhythmically in diabetics, stressing the importance of ROS levels. They found a marked circadian rhythm in DNA oxidation (in urine), uric acid (in serum), and nitric oxide (in serum) levels in nondiabetic men, but not in diabetic subjects (90). This study found that the peak levels of serum concentrations of the markers occurred in the early evening, suggesting a correlation between oxidative damage and increased metabolism.…”

Section: Diabetesmentioning

confidence: 61%

“…Several studies have shown evidence of differences in DNA damage, lipid peroxidation, and protein oxidation at different times of the day, thus indicating circadian oscillations of oxidative stress responses (51,90,97,100,176). These oscillations relate directly to the daily rhythm of antioxidant expression and protective enzyme activity levels (Fig.…”

Section: Rhythmicity Of the Cellular Antioxidant System: Patterns Of mentioning

confidence: 99%

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Circadian Rhythm Connections to Oxidative Stress: Implications for Human Health

Wilking

Ndiaye²,

Mukhtar³

et al. 2013

Antioxidants & Redox Signaling

238

192

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Significance: Oxygen and circadian rhythmicity are essential in a myriad of physiological processes to maintain homeostasis, from blood pressure and sleep/wake cycles, down to cellular signaling pathways that play critical roles in health and disease. If the human body or cells experience significant stress, their ability to regulate internal systems, including redox levels and circadian rhythms, may become impaired. At cellular as well as organismal levels, impairment in redox regulation and circadian rhythms may lead to a number of adverse effects, including the manifestation of a variety of diseases such as heart diseases, neurodegenerative conditions, and cancer. Recent Advances: Researchers have come to an understanding as to the basics of the circadian rhythm mechanism, as well as the importance of the numerous species of oxidative stress components. The effects of oxidative stress and dysregulated circadian rhythms have been a subject of intense investigations since they were first discovered, and recent investigations into the molecular mechanisms linking the two have started to elucidate the bases of their connection. Critical Issues: While much is known about the mechanics and importance of oxidative stress systems and circadian rhythms, the front where they interact has had very little research focused on it. This review discusses the idea that these two systems are together intricately involved in the healthy body, as well as in disease. Future Directions: We believe that for a more efficacious management of diseases that have both circadian rhythm and oxidative stress components in their pathogenesis, targeting both systems in tandem would be far more successful.

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Section: Diabetesmentioning

confidence: 61%

Section: Rhythmicity Of the Cellular Antioxidant System: Patterns Of mentioning

confidence: 99%

Circadian Rhythm Connections to Oxidative Stress: Implications for Human Health

Wilking

Ndiaye²,

Mukhtar³

et al. 2013

Antioxidants & Redox Signaling

238

192

View full text Add to dashboard Cite

show abstract

“…plasma uric acid, melatonin, reduced thiols), and oxidatively-generated substrates (e.g. plasma malondialdehyde, urinary 8-OHdG) exhibit strong circadian or other temporal fluctuations in amount or activity (Bridges et al 1992a;Hardeland et al 2003;Kanabrocki et al 2002Kanabrocki et al , 2004Kanabrocki et al , 2000Luo et al 1997;Niklowitz et al 2006;Reiter et al 1996;Valencia et al 2001). Whether the afternoon peak in salivary protein carbonyls (present study) is due to diurnal deficiencies in salivary gland / orophayngeal antioxidant defenses or augmented ROS production remains unclear.…”

Section: Discussionmentioning

confidence: 84%

Diurnal variations in salivary protein carbonyl levels in normal and cognitively impaired human subjects

Gornitsky

Geng

et al. 2008

AGE

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Oxidative stress has been documented in tissues and biofluids of subjects with sporadic Alzheimer disease (AD) and mild cognitive impairment (MCI). The aim of this study was to determine whether (a) salivary protein carbonyls are elevated in AD and MCI subjects, (b) salivary protein carbonyl contents in these groups exhibit diurnal variation, and (c) apolipoprotein E ɛ4 (apoE ɛ4) carrier status impacts salivary carbonyl concentrations or rhythmicity in the AD and MCI cohorts. Unstimulated saliva was collected at fixed intervals between 8 AM and 10 PM from 15 AD subject , 21 MCI subjects, and 30 cognitively-intact controls. Salivary protein carbonyl concentrations were measured by ELISA. ApoE genotyping was performed on the AD and MCI individuals. For all groups, mean protein carbonyl contents were significantly elevated at 2 PM relative to other time points surveyed. Mean salivary protein carbonyl concentrations did not differ among the diagnostic groups. ApoE ɛ4 carriers exhibited less temporal variation in salivary protein carbonyls relative to noncarriers. Thus, protein carbonyl content exhibits diurnal variation in adult human saliva. ApoE ɛ4 carrier status may impact oropharyngeal disease expression by attenuating the inherent diurnal variability in salivary redox homeostasis. Salivary protein carbonyls do not differentiate AD and MCI from normal individuals. In conclusion, oxidative stress has been documented in tissues and biofluids of subjects with sporadic AD and MCI. This article demonstrates that levels of protein carbonyls, a marker of oxidative stress, exhibit robust diurnal variation in the saliva of normal elderly, MCI, and AD subjects. Apolipoprotein E ɛ4 allele carrier status may attenuate this temporal variability in salivary redox homeostasis and thereby impact the natural history of oropharyngeal diseases.

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“…Oxidation of macromolecules within the body is part of normal homeostatic processes that regulate cellular signalling, growth and adaptations within tissues. Many lifestyle factors, including health history, nutritional status (Møller et al, 1996) and even internal circadian rhythm (Kanabrocki et al, 2002) can influence the degree of oxidative modification to these macromolecules. As a result, previous observational studies monitoring the impact of mental stress on markers of oxidative stress/ROS at one 'snap shot' warrant careful interpretation.…”

Section: Discussionmentioning

confidence: 99%