Circadian Rhythms in Catecholamine Metabolites and Cyclic Nucleotide Production

Kafka, Marian S.; Benedito, Marco Antonio Campana; Roth, Robert H.; Steele, Linda; Wolfe, William W.; Catravas, George N.

doi:10.3109/07420528609066354

Cited by 42 publications

(13 citation statements)

References 31 publications

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“…Indeed, dopamine-related substances, metabolites and receptors exhibit daily fluctuations in their levels in different brain regions (Kafka et al, 1986). Moreover, many brain regions implicated in reward-seeking behavior also contain "peripheral" (as opposed to SCN-driven) molecular clocks.…”

Section: Discussionmentioning

confidence: 99%

Circadian modulation of interval timing in mice

et al. 2011

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Temporal perception is fundamental to environmental adaptation in humans and other animals. To deal with timing and time perception, organisms have developed multiple systems that are active over a broad range of order of magnitude, the most important being circadian timing, interval timing and millisecond timing. The circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus, and is driven by a selfsustaining oscillator with a period close to 24 h. Time estimation in the second-to-minutes range -known as interval timing -involves the interaction of the basal ganglia and the prefrontal cortex. In this work we tested the hypothesis that interval timing in mice is sensitive to circadian modulations. Animals were trained following the peak-interval (PI) procedure. Results show significant differences in the estimation of 24-second intervals at different times of day, with a higher accuracy in the group trained at night, which were maintained under constant dark (DD) conditions. Interval timing was also studied in animals under constant light (LL) conditions, which abolish circadian rhythmicity. Mice under LL conditions were unable to acquire temporal control in the peak interval procedure.Moreover, short time estimation in animals subjected to circadian desynchronizations (modeling jet lag-like situations) was also affected. Taken together, our results indicate that short-time estimation is modulated by the circadian clock.© 2010 Elsevier B.V. All rights reserved. Keywords:Circadian rhythms Interval timingBasal ganglia Suprachiasmatic nuclei IntroductionTiming and time perception are fundamental to survival and goal reaching in humans and other animals. Organisms have developed diverse mechanisms for timing across different scales, the most important being circadian timing, interval timing and millisecond timing . The circadian pacemaker -which is driven by a self-sustaining oscillator with a period close to 24 h -is located in the suprachiasmatic nuclei (SCN) of the hypothalamus (Dunlap et al., 2004), and the principal signal that adjusts its activity is the light-dark cycle (Morin and Allen, 2006;Golombek and Rosenstein, 2010). The molecular mechanism of the endogenous circadian clock is comprised by interlocked transcription-translation feedback loops (Reppert and Weaver, 2002). On the other hand, the perception of shorter durations in the seconds-to-minutes range, known as interval timing, is crucial to learning, memory, decision making and other cognitive

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Section: Discussionmentioning

confidence: 99%

Circadian modulation of interval timing in mice

et al. 2011

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“…Indeed, rhythmic dopaminergic neurotransmission has been described in several regions of the brain, including mesolimbic structures. For example, DA and its related metabolites and receptors exhibit daily fluctuations in their levels in different brain regions (Kafka et al 1986). In particular, dopamine metabolism exhibits a diurnal rhythm in striatal regions, related to cyclic variations in the expression of DAT, DA receptors and TH (McClung 2007).…”

Section: Dopamine In the Circadian Timing Systemmentioning

confidence: 99%

Circadian and sleep disorders in Parkinson's disease

Videnović

Golombék

2013

Experimental Neurology

206

126

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“…Photoperiod is one of the largest potential sources of variation in ecometabolomics (Beck, ; Koštál, ). Numerous studies have indicated that many metabolic pathways undergo photo‐period dependent shifts, including the amino acid (Fernstrom et al., ; Gattolin et al., ), carbohydrate (Das et al., ; Seay & Thummel, ), lipid (Turek et al., ; Seay & Thummel, ), nucleotide (Kafka et al., ; Fustin et al., ), and even xenobiotic pathways (Claudel et al., ). These shifts can be correlated with the onset and cessation of major behavioural processes, perhaps most notable for entometabolomics is the control of feeding behaviour (Seay & Thummel, ).…”

Section: Entometabolomics: a Critique Of Comparative Studiesmentioning

confidence: 99%

Entometabolomics: applications of modern analytical techniques to insect studies

Snart

Hardy

2015

Entomologia Exp Applicata

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Metabolomic analyses can reveal associations between an organism's metabolome and further aspects of its phenotypic state, an attractive prospect for many life‐sciences researchers. The metabolomic approach has been employed in some, but not many, insect study systems, starting in 1990 with the evaluation of the metabolic effects of parasitism on moth larvae. Metabolomics has now been applied to a variety of aspects of insect biology, including behaviour, infection, temperature stress responses, 2 sedation, and bacteria–insect symbiosis. From a technical and reporting standpoint, these studies have adopted a range of approaches utilising established experimental methodologies. Here, we review current literature and evaluate the metabolomic approaches typically utilised by entomologists. We suggest that improvements can be made in several areas, including sampling procedures, the reduction in sampling and equipment variation, the use of sample extracts, statistical analyses, confirmation, and metabolite identification. Overall, it is clear that metabolomics can identify correlations between phenotypic states and underlying cellular metabolism that previous, more targeted, approaches are incapable of measuring. The unique combination of untargeted global analyses with high‐resolution quantitative analyses results in a tool with great potential for future entomological investigations.

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Circadian Rhythms in Catecholamine Metabolites and Cyclic Nucleotide Production

Cited by 42 publications

References 31 publications

Circadian modulation of interval timing in mice

Circadian modulation of interval timing in mice

Circadian and sleep disorders in Parkinson's disease

Entometabolomics: applications of modern analytical techniques to insect studies

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