Circadian and sleep disorders in Parkinson's disease

Videnović, Aleksandar; Golombék, Diego A.

doi:10.1016/j.expneurol.2012.08.018

Cited by 206 publications

(133 citation statements)

References 233 publications

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“…[18] Other causes of psychosis could be low quality of sleep [22], which is however also likely to cause non-dipping. [14] Up to 90% of PD patients suffer from sleep disruption [23,24] which may be caused by the hallmark PD pathophysiology of dopamine depletion which plays a crucial role in sleep regulation and circadian homeostasis [23].…”

Section: Introductionmentioning

confidence: 99%

Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease

et al. 2015

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Financial disclosure:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.Funding sources for study: None 2Background: Non-motor symptoms are increasingly recognized in Parkinson's Disease (PD) and include physical as well as psychological symptoms. A psychological condition that has been well studied in PD is psychosis.Cardiovascular autonomic dysfunction in PD can include a reversed or lack of blood pressure (BP) circadian rhythm, referred to as nocturnal non-dipping. The aim of this study was to determine the relationship between 24 hr ambulatory blood pressure measurements (ABPM), e.g., absence or presence of nocturnal dipping, and psychosis scores in PD.Methods: 21 patients with Parkinson's disease underwent 24 hr ABPM using an autonomic protocol. A decrease in nocturnal mean arterial blood pressure (MAP) of less than 10% was defined as non-dipping. Patients were interviewed (including the Brief Psychiatric Rating Scale; BPRS) for the assessment of psychosis.Results: 11 patients were dippers and 10 were non-dippers. BPRS scores were higher in non-dippers who on average met the criteria for psychosis (mean non-dipper BPRS: 34.3± 7,3 vs mean dipper BPRS: 27.5 ±5,3; cut off for "mildly ill" 31). There was a correlation between BPRS scores and non-dipping, indicating that those patients who had a blunted nocturnal fall in BP were more prone to psychotic symptoms.(Pearson's Correlation = .554, p =.009). Conclusion:These results suggest that a blunted BP rhythm in Parkinson's disease patients may possibly be associated with psychosis symptoms compared to patients whose BP decreases physiologically at night. This association warrants further investigation.3

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Section: Introductionmentioning

confidence: 99%

Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease

et al. 2015

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“…The prevalence of RBD in PD is about 15%-60% [27]. A longitudinal study by Claassen et al indicated that RBD often precedes the clinical manifestation of PD by Fig.…”

Section: Sleep Disordersmentioning

confidence: 99%

A New Perspective for Parkinson’s Disease: Circadian Rhythm

Wang

et al. 2016

Neurosci. Bull.

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Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei (SCN) in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson's disease (PD) exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options.

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“…Circadian deregulation has been recognized as a crucial cause of sleep disruption in most of the neurodegenerative disorders including PD and AD [204]. Importantly, circadian and sleep misalignment can influence the neurodegeneration itself [205]. A prime example of the bidirectional relationship between sleep/ circadian rhythm and neurodegeneration is AD.…”

Section: Parkinson's Disease and Related Psychobehavioural Anomaliesmentioning

confidence: 99%

“…A prime example of the bidirectional relationship between sleep/ circadian rhythm and neurodegeneration is AD. In AD, accumulation of Aβ disrupts sleep and enhances the risk of further Aβ accumulation and development of dementia [205]. The role of the circadian rhythm is not well studied in PD.…”

Section: Parkinson's Disease and Related Psychobehavioural Anomaliesmentioning

confidence: 99%

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Choudhury¹,

Sahu²,

Ramanujam³

et al. 2018

Neuropsychiatry

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Structural changes in different regions of the brain have become clinically relevant and regarded as the signature phenomenon for neurological diseases. Morphological changes in brain are also associated with neuronal and neurochemical alterations. Studies have showed that minute changes in neurochemical levels may have marked impact on the psychobehaviour of the subject. Several neurological disease profiles have been reported with such specific psychobehavioural expression. However, application of behavioural abnormalities as possible disease progress markers has not been considered and emphasised much. Reports suggested that-the subjects, who have already entered into the terminal stage of the disease, used to show cardinal behavioural signs for a specific disease profile. However, psychological expressions are comparatively early expressive. As most of the neurodegenerative disorders are unidirectional and progressive by nature, therapeutic intervention at the right time is essential for attaining the desired outcome. Moreover, early diagnosis can aid in managing the disease progression also. Psychobehavioural analysis could meet the expected outcome of disease diagnosis if implemented properly and timely. In the present review, we have amalgamated the reported behavioural anomalies with the supportive background from neurochemical basis. Further, we have concluded that behaviour centric studies could be a potential diagnostic tool for the early diagnosis of major neurological diseases such as Alzheimer disease, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), Bipolar disorder, Schizophrenia, Impulse control disorder (ICD) and Obsessive-compulsive disorder (OCD).

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Circadian and sleep disorders in Parkinson's disease

Cited by 206 publications

References 233 publications

Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease

Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease

A New Perspective for Parkinson’s Disease: Circadian Rhythm

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

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