Circadian rhythm of leucocytes and lymphocyte subsets and its possible correlation with the function of the autonomic nervous system

Suzuki, Susumu; Toyabe, Shin; Moroda, Tetsuya; Tada, Takashi; Tsukahara, Akihiro; Iiai, Tsuneo; Minagawa, Masahiro; Maruyama, Satoshi; Hatakeyama, Katsuyoshi; Endoh, Kazuo; Abo, Toru

doi:10.1046/j.1365-2249.1997.4411460.x

Cited by 201 publications

(162 citation statements)

References 17 publications

(31 reference statements)

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“…14 NKT cells express adrenoceptors. 20 Furthermore, work by Minagawa and colleagues suggests that sympathetic neurotransmitters regulate the accumulation of NKT cells in the liver after partial hepatectomy. 17 However, it is not known how important sympathetic neurotransmitters are for the general maintainence of hepatic NKT cell populations.…”

Section: Resultsmentioning

confidence: 99%

Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis

Oben

Yang

et al. 2004

Hepatology

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It is not known why natural killer T (NKT) cells, which modulate liver injury by regulating local cytokine production, are reduced in leptin-deficient ob/ob mice. NKT cells express adrenoceptors. Thus, we hypothesize that the low norepinephrine (NE) activity of ob/ob mice promotes depletion of liver NKT cells, thereby sensitizing ob/ob livers to lipopolysaccharide (LPS) toxicity. To evaluate this hypothesis, hepatic NKT cells were quantified in wild-type mice before and after treatment with NE inhibitors, and in dopamine ␤-hydroxylase knockout mice (which cannot synthesize NE) and ob/ob mice before and after 4 weeks of NE supplementation. Decreasing NE activity consistently reduces liver NKT cells, while increasing NE has the opposite effect. Analysis of hepatic and thymic NKT cells in mice of different ages demonstrate an age-related accumulation of hepatic NKT cells in normal mice, while liver NKT cells become depleted after birth in ob/ob mice, which have increased apoptosis of hepatic NKT cells. NE treatment inhibits apoptosis and restores hepatic NKT cells. In ob/ob mice with reduced hepatic NKT cells, hepatic T and NKT cells produce excessive T helper (Th)-1 proinflammatory cytokines and the liver is sensitized to LPS toxicity. NE treatment decreases Th-1 cytokines, increases production of Th-2 cytokines, and reduces hepatotoxicity. Studies of CD1d-deficient mice, which lack the receptor required for NKT cell development, demonstrate that they are also unusually sensitive to LPS hepatotoxicity. In conclusion, low NE activity increases hepatic NKT cell apoptosis and depletes liver NKT cells, promoting proinflammatory polarization of hepatic cytokine production that sensitizes the liver to LPS toxicity. (HEPATOLOGY 2004;40:434 -441.)

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Section: Resultsmentioning

confidence: 99%

Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis

Oben

Yang

et al. 2004

Hepatology

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“…In humans, the absolute counts of blood cells and their subsets were varying from one person to another. Furthermore, existing evidence had demonstrated that granulocytes show an increase in the daytime while T cells, B cells, alphabet T cells, and CD4+ lymphocytes show an increase at night (Suzuki et al, 1997). Thus the blood cell ratio as a relative value can eliminate the influence of these changes and reflect the anti-tumor efficiency of the host immune mechanism more exactly than blood cell count can.…”

Section: Figure 1 Impact Of Pretherapeutic Lymphocyte Ratio On 5-yeamentioning

confidence: 99%

Circulating Lymphocytes as Predictors of Sensitivity to Preoperative Chemoradiotherapy in Rectal Cancer Cases

Dou¹,

Wang²,

Huang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…It is known that catecholamine and cortisol levels reflect the status of the ANS (14,16,22,23); thus, these were measured before and after SRDT. After SRDT, the serum level of noradrenaline was significantly elevated (313.3 ± 207.6 → 380.3 ± 181.4 pg/ mL, P < 0.05); that of adrenaline tended to increase however, it was not statistically significant (53.3 ± 23.0 → 61.3 ± 29.1 pg/mL, P > 0.05).…”

Section: Levels Of Catecholamines (Adrenaline Noradrenaline and Dopamentioning

confidence: 99%

Skin rubdown with a dry towel, ^|^lsquo;kanpu-masatsu' is an aerobic exercise affecting body temperature, energy production, and the immune and autonomic nervous systems

et al. 2012

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Skin rubdown using a dry towel (SRDT) to scrub the whole body is a traditional therapy for health promotion. To investigate its mechanism, 24 healthy male volunteers were studied. Body temperature, pulse rate, red blood cells (RBCs), serum levels of catecholamines and cortisol, blood gases (PO 2 , sO 2 , PCO 2 and pH), lactate and glucose, and the ratio and number of white blood cells (WBCs) were assessed before and after SRDT. After SRDT, pulse rate and body temperature were increased. PO 2 , sO 2 and pH were also increased and there was no Rouleaux formation by RBCs. Lactate level tended to increase, whereas that of glucose did not. Adrenaline and noradrenaline levels increased, indicating sympathetic nerve (SN) dominance with increase in granulocytes. WBC number and ratio were divided into two groups according to granulocyte ratio (≤ or < 60%) before SRDT: a normal group and a SN group. Only in the SN group did the granulocyte ratio decrease and the lymphocyte ratio and number increase after SRDT. It is suggested that SRDT is a mild aerobic, systemic exercise that might affect the immune system via the autonomic nervous system. Skin rubdown using a dry towel (SRDT) to scrub the whole body, called 'kanpu-masatsu' is popular in Japan. It is said that it became common in 1940 as a prevention against infectious respiratory diseases in elementary educational institutions; however, its origin is unknown (6). At present, officer candidates in the Japanese Maritime Self Defense Force practice it every morning, as do students in elementary schools and kindergartens, where it is required as part of the winter daily schedule to prevent asthma and colds. SRDT thus remains popular nationwide as a health promoting therapy.SRDT has parallels with other traditional oriental therapies such as acupuncture, moxibustion and massage, all of which stimulate the skin. These therapies have much supporting evidence for their effects in preventing colds, enhancing immunity, increasing blood flow, activating natural killer cells via somato-autonomic reflexes, and improving metabolism via the autonomic nervous system (ANS) (5,8,9,12,(22)(23)(24). However, there have been insufficient studies of the effects of SRDT. There is a report that SRDT activates natural killer cells (6), but the subjects of that study were limited to bedridden elderly patients, and SRDT was performed not by the subjects themselves but by their nursing personnel. In the present study, healthy volunteers were investigated. We assessed body temperature

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Circadian rhythm of leucocytes and lymphocyte subsets and its possible correlation with the function of the autonomic nervous system

Cited by 201 publications

References 17 publications

Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis

Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis

Circulating Lymphocytes as Predictors of Sensitivity to Preoperative Chemoradiotherapy in Rectal Cancer Cases

Skin rubdown with a dry towel, ^|^lsquo;kanpu-masatsu' is an aerobic exercise affecting body temperature, energy production, and the immune and autonomic nervous systems

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