Circadian Rhythm of Acid Phosphatase in Mouse Testis Lysosomes

Russo, James J.

doi:10.1530/jrf.0.0230021

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Ellis & Berliner (1963) reported a triphasic response of androgen production (including testosterone) to radiation. Since it has been suggested that lysosomes are involved in steroid synthesis and are inhibitory to androgen production (Frank & Christensen, 1968;Dietert & Scallen, 1969;Russo, 1970), it is possible that the enhanced activity of lyso¬ somal enzymes during the first week is in some way related to the androgen production. Since it has been suggested that lysosomes are involved in steroid synthesis and are inhibitory to androgen production (Frank & Christensen, 1968;Dietert & Scallen, 1969;Russo, 1970), it is possible that the enhanced activity of lyso¬ somal enzymes during the first week is in some way related to the androgen production.…”

Section: Discussionmentioning

confidence: 99%

Radiation Effects on Rat Testes

Gupta¹,

Bawa²

1975

Reproduction

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Acid phosphatase is present in the nucleus and cytoplasm of cells in the seminiferous tubules and the interstitium of rat testes. The effect of irradiation on acid phosphatase is dependent on the environmental temperature and the dose of irradiation. It appears that initial rise in the enzyme at a low radiation dose and a high environmental temperature or at a high dose and low temperature is associated with a lysosomal breakdown of the germinal cells of the testes. A decrease in acid phosphatase in the advanced stages of radiation injury is a secondary radiation effect which may lead to decreased metabolic synthesis of phosphate esters owing to the unavailability of orthophosphate in the testicular tubules. The reduced acid phosphatase activity can be detected in the seminiferous tubules, suggesting that the enzyme activity is related to the state of the germ cell population. An initial increase in acid phosphatase is matched by an initial rise in acid DNAse within hours of irradiation, further suggesting that there is radiation interaction with the cells of the germinal epithelium. The enhanced activity of DNAse following a 2nd week of irradiation at 2000 R confirms the phagocytic activity of the non-germinal cells.

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