An update on the role and potential mechanisms of clock genes regulating spermatogenesis: A systematic review of human and animal experimental studies

He, Mengchao; Liu, Kun; Cao, Jun; Chen, Qing

doi:10.1007/s11154-022-09783-0

Rev Endocr Metab Disord

2023

DOI: 10.1007/s11154-022-09783-0

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An update on the role and potential mechanisms of clock genes regulating spermatogenesis: A systematic review of human and animal experimental studies

Mengchao He

Kun Liu²,

Jun Cao

et al.

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2024

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Light pollution: time to consider testicular effects

Liu

2024

Front. Toxicol.

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Technological advances have led to a modern-day lighting and smartphone revolution, with artificial light exposure at night increasing to levels never before seen in the evolutionary history of living systems on Earth. Light as a pollutant, however, remains largely unrecognized, and the reproductive effects of light pollution are mostly if not entirely unconsidered. This is despite the reproductive system being intricately linked to metabolism and the circadian system, both of which can be disturbed even by low levels of light. Here, we aim to change this perspective by reviewing the physiological and pathophysiological mechanisms by which light exposure alters the intricate hormonal, metabolic and reproductive networks that are relevant to reproductive toxicology. Nascent human studies have recently identified the photoreceptors responsible for the light dose relationship with melatonin suppression and circadian re-entrainment, directly shown the association between the alignment of light-dark cycles with activity-rest cycles on metabolic health and provided proof-of-principle that properly timed blue light-enriched and blue light-depleted delivery can accelerate circadian re-entrainment. With these advances, there is now a need to consider testicular effects of light pollution.

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Light pollution: time to consider testicular effects

Liu

2024

Front. Toxicol.

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An update on the role and potential mechanisms of clock genes regulating spermatogenesis: A systematic review of human and animal experimental studies

Cited by 1 publication

References 193 publications

Light pollution: time to consider testicular effects

Light pollution: time to consider testicular effects

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