Circadian Regulation of Tshb Gene Expression by Rev-Erbα (NR1D1) and Nuclear Corepressor 1 (NCOR1)

Aninye, Irene O.; Matsumoto, Shunichi; Sidhaye, Aniket; Wondisford, Fredric E.

doi:10.1074/jbc.m114.569723

Cited by 38 publications

(16 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…55 In vitro data also indicate that N-CoR targets NR1D1 (also known as Rev-Erbα) not THR at the Tshb promoter to regulate basal circadian expression patterns of this gene. 56 It is also possible that a completely different set of cofactors is recruited when THR is bound to a negative TRE. For example, nuclear factor RIP140 interacts with THRα–RXR or THRβ–RXR heterodimers, and this interaction might lead to inhibition of transcription mediated by THR homodimers.…”

Section: Thyroid Hormone Receptorsmentioning

confidence: 99%

Thyroid hormone receptors and resistance to thyroid hormone disorders

2014

Self Cite

View full text Add to dashboard Cite

Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs), which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor β (THRB) genes. Patients with mutations in THRB present with resistance to thyroid hormone β (RTHβ), which is a disorder characterized by elevated levels of thyroid hormone, normal or elevated levels of TSH and goitre. Mechanistic insights about the contributions of THRβ to various processes, including colour vision, development of the cochlea and the cerebellum, and normal functioning of the adult liver and heart, have been obtained by either introducing human THRB mutations into mice or by deletion of the mouse Thrb gene. The introduction of the same mutations that mimic human THRβ alterations into the mouse Thra and Thrb genes resulted in distinct phenotypes, which suggests that THRA and THRB might have non-overlapping functions in human physiology. These studies also suggested that THRA mutations might not be lethal. Seven patients with mutations in THRα have since been described. These patients have RTHα and presented with major abnormalities in growth and gastrointestinal function. The hypothalamic–pituitary–thyroid axis in these individuals is minimally affected, which suggests that the central T3 feedback loop is not impaired in patients with RTHα, in stark contrast to patients with RTHβ.

show abstract

Section: Thyroid Hormone Receptorsmentioning

confidence: 99%

Thyroid hormone receptors and resistance to thyroid hormone disorders

2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…The mechanism of circadian TSH secretion is becoming increasingly clear, with the nuclear corepressor, NCOR, now known to impinge on thyroid hormone receptors bound to TSH subumit genes [12]. The 24-h mean concentrations of prolactin in plasma were the same in all groups, whereas those of LH and FSH were twice as high in the elderly as in the young men and eight and 23 times higher, respectively, in the elderly women.…”

Section: Circadian Cycles In Patients Undergoing Clinical Laboratory mentioning

confidence: 91%

Chronobiology and circadian rhythms establish a connection to diagnosis

Nydegger

Escobar

Risch³

et al. 2014

Diagnosis

View full text Add to dashboard Cite

Circadian rhythms are synchronized by the light/dark (L/D) cycle over the 24-h day. A suprachiasmatic nucleus in the hypothalamus governs time keeping based on melanopsin messages from the retina in the eyes and transduces regulatory signals to tissues through an array of hormonal, metabolic and neural outputs. Currently, vague impressions on circadian regulation in health and disease are replaced by scientific facts: in addition to L/D cyling, oscillation is maintained by genetic (Clock, Bmal1, Csnk1, CHRONO, Cry, Per) programs, autonomous feedback loops, including melatonin activities, aerobic glycolysis intensity and lipid signalling, among others. Such a multifaceted influential system on circadian rhythm is bound to be fragile and genomic clock acitvities can become disrupted by epigenetic modifications or such environmental factors as mistimed sleep and feeding schedules albeit leaving the centrally driven melatonindependent pacemakter more or less unaffected.

show abstract

“…Therefore, NR1D1 seems to be the principal metronome of the body. NR1D1 regulates the transcription of “the long-day gene” TSHB (thyroid stimulating hormone, beta), and through this action NR1D1 is also a link between the effects of light and the seasonal variation in behavior ( 36 ). Transcription of TSHB is induced to a greater extent about 14 h after dawn of the first long day in the spring by the increasing exposure to light ( 37 ).…”

Section: Role Of Orphan Nuclear Receptorsmentioning

confidence: 99%

Circadian Clock Proteins in Mood Regulation

Partonen

2015

Front. Psychiatry

View full text Add to dashboard Cite

Mood regulation is known to be affected by the change of seasons. Recent research findings have suggested that mood regulation may be influenced by the function of circadian clocks. In addition, the activity of brown adipocytes has been hypothesized to contribute to mood regulation. Here, the overarching link to mood disorders might be the circadian clock protein nuclear receptor subfamily 1, group D, member 1.

show abstract

Circadian Regulation of Tshb Gene Expression by Rev-Erbα (NR1D1) and Nuclear Corepressor 1 (NCOR1)

Cited by 38 publications

References 37 publications

Thyroid hormone receptors and resistance to thyroid hormone disorders

Thyroid hormone receptors and resistance to thyroid hormone disorders

Chronobiology and circadian rhythms establish a connection to diagnosis

Circadian Clock Proteins in Mood Regulation

Contact Info

Product

Resources

About