Circadian hemodynamics in heart transplant recipients

Idema, R. N.; Meiracker, Anton H. van den; Veld, A. J. Man In't; Balk, A. H. M. M.; E, Bos; Schalekamp, M. A. D. H.

doi:10.1097/00004872-199312050-00024

Cited by 4 publications

(1 citation statement)

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“…The circadian rhythm in heart rate also persists after chronic functional autonomic blockade: (i) knockout of the muscarinic M 2 ACh receptor or knockout of the  1 ,  2 and  3 receptors mediating the effects of ACh and catecholamines released by the autonomic nervous system on the heart does not block the circadian rhythm in heart rate (although this does not rule out a role for neuropeptides released from vagal nerve endings) (Swoap et al, 2008); and (ii) heart transplant patients with denervated hearts show a circadian rhythm in heart rate (although this does not rule out a role for a circadian variation in the level of circulating catecholamines) (Idema et al, 1994;Kotsis et al, 2005). However, the effects of chronic intervention should be viewed cautiously, because chronic intervention may lead to compensatory transcriptional remodelling.…”

Section: Regulation Of the Hcn Channels In Health -Circadian Rhythm In Heart Ratementioning

confidence: 98%

Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

Boyett

Yanni

Tellez

et al. 2021

Progress in Biophysics and Molecular Biology

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Section: Regulation Of the Hcn Channels In Health -Circadian Rhythm In Heart Ratementioning

confidence: 98%

Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

Boyett

Yanni

Tellez

et al. 2021

Progress in Biophysics and Molecular Biology

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Loss of nocturnal blood pressure fall after liver transplantation during immunosuppressive therapy*

et al. 1995

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Hypertension, which develops after organ transplantation during immunosuppression with cyclosporine (CSA), is often associated with a loss of nocturnal decrease in blood pressure. Few data correlate circadian blood pressure patterns before transplant with those observed at fixed time points after transplant, or address the role of alternate immunosuppressive agents such as FK506. FK506 is unrelated structurally to CSA and less often leads to hypertension early after transplant. The present study compared nocturnal blood pressure patterns in patients with end-stage liver disease (ESLD) before transplant to those of transplant recipients receiving either FK506 (0.15 mg/kg/day) plus prednisone or CSA (2 to 3 mg/kg/day) plus prednisone and azathioprine after orthotopic liver transplantation. Overnight ambulatory blood pressure profiles were studied in 13 pretransplant ESLD patients and in 34 patients (FK506: n = 13; CSA: n = 21) treated with different steroid doses (24 +/- 11 mg/day FK506; 34 +/- 3 mg/day CSA), according to protocol, 4 weeks (range, 2 to 7 weeks) after liver transplant. Mean blood pressure and heart rate values from awake and nocturnal 5-h time blocks were compared to 13 normotensive control subjects. Patients with ESLD were normotensive and maintained a normal nocturnal blood pressure fall (125 +/- 3/74 +/- 2 mm Hg awake; 109 +/- 3/60 +/- 2 mm Hg nocturnal). Awake ambulatory blood pressures were higher in CSA patients than in FK506 patients (148 +/- 3/95 +/- 2 v 128 +/- 3/78 +/- 2 mm Hg, respectively; P < .01), despite reduced glomerular filtration rates in both transplant groups. Both immunosuppressive regimens led to a loss of nocturnal blood pressure fall, as compared to ESLD patients or normotensive controls.(ABSTRACT TRUNCATED AT 250 WORDS)

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Nocturnal reduction of blood pressure and the antihypertensive response to a diuretic or angiotensin converting enzyme inhibitor in obese hypertensive patients

Weir

Reisin

Falkner

et al. 1998

American Journal of Hypertension

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During a 12-week, multicenter study to evaluate the efficacy and safety of lisinopril and hydrochlorothiazide (HCTZ) for the treatment of obesity-related hypertension, ambulatory blood pressure (ABP) monitoring was performed both at baseline and at study completion in 124 patients. Patients were randomized to three groups: placebo, lisinopril (10, 20, or 40 mg/day), or HCTZ (12.5, 25, or 50 mg/day). All groups were matched with regard to sex, race, age, body mass index, and waist/hip ratio. The primary analysis of ABP data revealed that both lisinopril and HCTZ effectively lowered mean 24-h systolic (SBP) and diastolic (DBP) blood pressure compared with placebo, (mean change from baseline SBP/DBP: -12.0/-8.2, -10.6/-5.5, and -0.3/-0.5 mm Hg, respectively); however, lisinopril lowered DBP better than HCTZ (P < .05). Secondary analyses of groups revealed that men responded better to lisinopril than HCTZ (-11.9/-7.3 v -6.6/-3.5 mm Hg, respectively), whereas women responded well to both drugs. White patients responded better to lisinopril than HCTZ, whereas black patients showed a significant response to HCTZ only. Response to treatment was also influenced by patient classification of 24-h blood pressure profiles, ie, "dipper" or "nondipper." Overall, the majority of obese hypertensives were nondippers. Nondippers (n = 82) responded well to both drugs (-10.4/-6.9 v -12.5/-5.7 mm Hg, P < .05 v placebo), whereas dippers (n = 42) responded to lisinopril (-11.7/ -9.4 mm Hg, P < .05 v placebo and HCTZ), but not HCTZ (-5.6/-4.1 mm Hg, P = NS v placebo). Results of 24-h ABP data show that both lisinopril and HCTZ are effective therapies for obesity-related hypertension and that response to treatment is influenced by sex, race, and dipper/nondipper status.

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Circadian hemodynamics in heart transplant recipients

Cited by 4 publications

References 0 publications

Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

Loss of nocturnal blood pressure fall after liver transplantation during immunosuppressive therapy*

Nocturnal reduction of blood pressure and the antihypertensive response to a diuretic or angiotensin converting enzyme inhibitor in obese hypertensive patients

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