Circadian fluctuations in tibia cartilage — Assayable pituitary homogenates of fed and starved weanling female rats

Bahorsky, Michael; Bernardis, Lee L.

doi:10.1007/bf01897609

Cited by 5 publications

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“… 14 , 15 Soon after, the metabolic rhythms of the epiphysis and condylar cartilage were also studied in detail. 16 , 17 , 18 , 19 , 20 , 21 , 22 Additionally, research reported that, in the absence of alterations in environmental factors, the thickness and volume of articular cartilage also vary from day to night. 23 , 24 Collectively, these findings suggest the possibility of an autonomously controlled clock in cartilage.…”

Section: Evidence Of Circadian Clock In Cartilagementioning

confidence: 99%

“…In 1962, Simmons described diurnal variations in cell proliferation and bone growth plate metabolism 14,15 . Soon after, the metabolic rhythms of the epiphysis and condylar cartilage were also studied in detail 16‐22 . Additionally, research reported that, in the absence of alterations in environmental factors, the thickness and volume of articular cartilage also vary from day to night 23,24 .…”

Section: Evidence Of Circadian Clock In Cartilagementioning

confidence: 99%

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Drivers of phenotypic variation in cartilage: Circadian clock genes

Song

Bai

Meng

et al. 2021

J Cellular Molecular Medi

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Endogenous homeostasis and peripheral tissue metabolism are disrupted by irregular fluctuations in activation, movement, feeding and temperature, which can accelerate negative biological processes and lead to immune reactions, such as rheumatoid arthritis (RA) and osteoarthritis (OA). This review summarizes abnormal phenotypes in articular joint components such as cartilage, bone and the synovium, attributed to the deletion or overexpression of clock genes in cartilage or chondrocytes. Understanding the functional mechanisms of different genes, the differentiation of mouse phenotypes and the prevention of joint ageing and disease will facilitate future research.

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