Circadian expression of Mel1a and PL-II genes in placenta: effects of melatonin on the PL-II gene expression in the rat placenta

Lee, Chae Kwan; Moon, Dae-Hyuk; Shin, Chang-Hyun; Kim, Haekwon; Yoon, Yong‐Dal; Kang, Han Seung; Lee, Byung Ju; Kang, Sung Goo

doi:10.1016/s0303-7207(02)00414-8

Cited by 32 publications

(33 citation statements)

References 47 publications

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“…Indeed, melatonin receptors were identified in human placenta (Iwasaki et al, 2005) and melatonin was found to affect in vitro human chorionic gonadotrophin secretion by human trophoblast cells. Melatonin receptors were identified also in rat placenta where its involvement in regulating Placental Lactogen II gene expression has been proposed (Lee et al, 2003). Whereas melatonin receptors expressed in the sheep placenta has to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Seasonal effects on birth weight of lambs born to prolific ewes maintained under intensive management

Gootwine¹,

Rozov²

2006

Livestock Science

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Section: Discussionmentioning

confidence: 99%

Seasonal effects on birth weight of lambs born to prolific ewes maintained under intensive management

Gootwine¹,

Rozov²

2006

Livestock Science

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“…Furthermore, mRNA transcripts of the melatonin-synthesizing enzymes and both MT1 and MT2 melatonin receptors were demonstrated in the first-tri- mester human placenta (Iwasaki et al, 2005). MT1 was also detected in the rat placenta, and melatonin agonist decreased the expression of placenta lactogen-II (PL-II) mRNA in cultured late-pregnancy rat placental tissues (Lee et al, 1999, 2003). …”

Section: Melatonin Receptors In the Reproductive And Gestational Tmentioning

confidence: 99%

Melatonin membrane receptors in peripheral tissues: Distribution and functions

Slominski

Reíter

Schlabritz‐Loutsevitch

et al. 2012

Molecular and Cellular Endocrinology

585

470

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Many of melatonin’s actions are mediated through interaction with the G-protein coupled membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or, indirectly with nuclear orphan receptors from the RORα/RZR family. Melatonin also binds to the quinone reductase II enzyme, previously defined the MT3 receptor. Melatonin receptors are widely distributed in the body; herein we summarize their expression and actions in non-neural tissues. Several controversies still exist regarding, for example, whether melatonin binds the RORα/RZR family. Studies of the peripheral distribution of melatonin receptors are important since they are attractive targets for immunomodulation, regulation of endocrine, reproductive and cardiovascular functions, modulation of skin pigmentation, hair growth, cancerogenesis, and aging. Melatonin receptor agonists and antagonists have an exciting future since they could define multiple mechanisms by which melatonin modulates the complexity of such a wide variety of physiological and pathological processes.

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“…The trilaminar trophoblast includes a single layer of mononuclear sinusoidal trophoblast giant cells (S-TGCs) that line the maternal blood sinusoids (Coan et al, 2005;Simmons and Cross, 2005;Simmons et al, 2007), and two layers of syncytiotrophoblast, SynT-I and -II, the latter of which is in contact with fetal endothelial cells (Simmons and Cross, 2005;Watson and Cross, 2005). The STGCs are secretory in nature, expressing hormones such as placental lactogen II (Campbell et al, 1989;Dai et al, 2000;Deb et al, 1991;Ishida et al, 2004;Lee et al, 2003;Sahgal et al, 2000;Simmons and Cross, 2005;Simmons et al, 2007), and are therefore likely to have a primary endocrine function. S-TGCs are loosely attached to the underlying syncytial layers via desmosomal adhesions and contain fenestrations to allow the SynT-I cells direct access to maternal blood (Coan et al, 2005;Davies and Glasser, 1968;Hernandez-Verdun, 1974).…”

Section: Introductionmentioning

confidence: 99%

Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth

et al. 2008

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The labyrinth of the rodent placenta contains villi that are the site of nutrient exchange between mother and fetus. They are covered by three trophoblast cell types that separate the maternal blood sinusoids from fetal capillaries -a single mononuclear cell that is a subtype of trophoblast giant cell (sinusoidal or S-TGC) with endocrine function and two multinucleated syncytiotrophoblast layers, each resulting from cell-cell fusion, that function in nutrient transport. The developmental origins of these cell types have not previously been elucidated. We report here the discovery of cell-layer-restricted genes in the mid-gestation labyrinth (E12.5-14.5) including Ctsq in S-TGCs (also Hand1-positive), Syna in syncytiotrophoblast layer I (SynT-I), and Gcm1, Cebpa and Synb in syncytiotrophoblast layer II (SynT-II). These genes were also expressed in distinct layers in the chorion as early as E8.5, prior to villous formation. Specifically, Hand1 was expressed in apical cells lining maternal blood spaces (Ctsq is not expressed until E12.5), Syna in a layer immediately below, and Gcm1, Cebpa and Synb in basal cells in contact with the allantois. Cebpa and Synb were co-expressed with Gcm1 and were reduced in Gcm1 mutants. By contrast, Hand1 and Syna expression was unaltered in Gcm1 mutants, suggesting that Gcm1-positive cells are not required for the induction of the other chorion layers. These data indicate that the three differentiated trophoblast cell types in the labyrinth arise from distinct and autonomous precursors in the chorion that are patterned before morphogenesis begins.

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Circadian expression of Mel1a and PL-II genes in placenta: effects of melatonin on the PL-II gene expression in the rat placenta

Cited by 32 publications

References 47 publications

Seasonal effects on birth weight of lambs born to prolific ewes maintained under intensive management

Seasonal effects on birth weight of lambs born to prolific ewes maintained under intensive management

Melatonin membrane receptors in peripheral tissues: Distribution and functions

Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth

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