Circadian dysfunction and Alzheimer's disease – An updated review

Ahmad, Faizan; Sachdeva, Punya; Sarkar, Jasmine; Izhaar, Raafiah

doi:10.1002/agm2.12221

Cited by 19 publications

(12 citation statements)

References 147 publications

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“…Therefore, it has been confirmed in numerous studies that depression as a neurodegenerative disorder resulting in atrophy of the brain regions 21 . Neurodegenerative disorders develop due to loss of neurons, resulting in a decline in cognitive functioning of the brain 22–28 . Several studies have identified the hippocampus as the key brain region linked to depression, and hippocampal plasticity occurs in patients with depression 29 .…”

Section: Overview On Depressionmentioning

confidence: 96%

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Sachdeva

Sachdeva²,

Ghosh

et al. 2023

Ibrain

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Major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are the most common causes of emotional distress that impair an individual's quality of life. MDD is a chronic mental illness that affects 300 million people across the world. Clinical manifestations of MDD include fatigue, loss of interest in routine tasks, psychomotor agitation, impaired ability to focus, suicidal ideation, hypersomnolence, altered psychosocial functioning, and appetite loss. Individuals with depression also demonstrate a reduced behavioral response while experiencing pleasure, a symptom known as anhedonia. Like MDD, PTSD is a prevalent and debilitating psychiatric disorder resulting from a traumatic incident such as sexual assault, war, severe accident, or natural disaster. Symptoms such as recalling event phases, hypervigilance, irritability, and anhedonia are common in PTSD. Both MDD and PTSD pose enormous socioeconomic burdens across the globe. The search for effective treatment with minimal side effects is still ongoing. Ketamine is known for its anesthetic and analgesic properties. Psychedelic and psychotropic effects of ketamine have been found on the nervous system, which highlights its toxicity. In this article, the effectiveness of ketamine as a potential therapeutic for PTSD and MDD along with its mechanisms of action, clinical trials, and possible side effects have been discussed.

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Section: Overview On Depressionmentioning

confidence: 96%

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Sachdeva

Sachdeva²,

Ghosh

et al. 2023

Ibrain

Self Cite

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“…259 This is in addition to its ability to inhibit the secretion of soluble APP (amyloid precursor protein) in various cell lines through APP maturation. 262,263 In in vitro and in vivo models, treatment with melatonin decreased amyloid beta production and deposition. [264][265][266][267] Clinical studies are, therefore, needed to explore the potential role of melatonin as a treatment in slowing AD progression and for possible restoration of sleep and circadian rhythms in preclinical AD.…”

Section: Compendium: Circadian Mechanisms In Cardio/ Cerebrovascular ...mentioning

confidence: 99%

Stroke in the Time of Circadian Medicine

Mergenthaler,

Balami,

Neuhaus

et al. 2024

Circulation Research

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Time-of-day significantly influences the severity and incidence of stroke. Evidence has emerged not only for circadian governance over stroke risk factors, but also for important determinants of clinical outcome. In this review, we provide a comprehensive overview of the interplay between chronobiology and cerebrovascular disease. We discuss circadian regulation of pathophysiological mechanisms underlying stroke onset or tolerance as well as in vascular dementia. This includes cell death mechanisms, metabolism, mitochondrial function, and inflammation/immunity. Furthermore, we present clinical evidence supporting the link between disrupted circadian rhythms and increased susceptibility to stroke and dementia. We propose that circadian regulation of biochemical and physiological pathways in the brain increase susceptibility to damage after stroke in sleep and attenuate treatment effectiveness during the active phase. This review underscores the importance of considering circadian biology for understanding the pathology and treatment choice for stroke and vascular dementia and speculates that considering a patient’s chronotype may be an important factor in developing precision treatment following stroke.

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“…These individuals also show lower melatonin levels and a dysregulated HPA axis [89]. In fact, circadian dysfunction is a common symptom of AD [90] and a fundamental factor in aggravating the disease [91]. Although impaired circadian rhythms have long been considered a consequence of AD, recent evidence suggests a possible causative role for circadian dysfunction in its pathogenesis.…”

Section: Circadian Disruption In Mental Health Disordersmentioning

confidence: 99%

Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies

Codoñer‐Franch

Gombert

Martínez-Raga

et al. 2023

IJMS

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Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired circadian rhythms are associated with mental disorders. The evening chronotype, which is linked to circadian misalignment, is a risk factor for severe psychiatric symptoms and psychiatric metabolic comorbidities. Resynchronization of circadian rhythms commonly improves psychiatric symptoms. Furthermore, evidence indicates that preventing circadian misalignment may help reduce the risk of psychiatric disorders and the impact of neuro–immuno–metabolic disturbances in psychiatry. The gut microbiota exhibits diurnal rhythmicity, as largely governed by meal timing, which regulates the host’s circadian rhythms. Temporal circadian regulation of feeding has emerged as a promising chronotherapeutic strategy to prevent and/or help with the treatment of mental illnesses, largely through the modulation of gut microbiota. Here, we provide an overview of the link between circadian disruption and mental illness. We summarize the connection between gut microbiota and circadian rhythms, supporting the idea that gut microbiota modulation may aid in preventing circadian misalignment and in the resynchronization of disrupted circadian rhythms. We describe diurnal microbiome rhythmicity and its related factors, highlighting the role of meal timing. Lastly, we emphasize the necessity and rationale for further research to develop effective and safe microbiome and dietary strategies based on chrononutrition to combat mental illness.

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Circadian dysfunction and Alzheimer's disease – An updated review

Cited by 19 publications

References 147 publications

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Stroke in the Time of Circadian Medicine

Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies

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