Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease

Shi, Dongmei; Chen, Jie; Wang, Jiaofeng; Yao, Jianfeng; Huang, Yiqin; Zhang, Gansheng; Bao, Zhijun

doi:10.3389/fphys.2019.00423

Cited by 70 publications

(51 citation statements)

References 81 publications

(82 reference statements)

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“…For example, previous studies showed that clock genes have demonstrated a role of circadian rhythm in muscle atrophy and bone remodeling [ 53 , 54 , 55 ]. In addition, these clock genes have been implicated in NAFLD [ 56 ], the symptoms of which have been observed in mice during spaceflight [ 10 ]. Furthermore, Arntl plays a role in the circadian regulation of acute glucocorticoid secretion in the adrenal glands in response to stress [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight

Fujita

Rutter

Ong

et al. 2020

Life

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Rodent models have been widely used as analogs for estimating spaceflight-relevant molecular mechanisms in human tissues. NASA GeneLab provides access to numerous spaceflight omics datasets that can potentially generate novel insights and hypotheses about fundamental space biology when analyzed in new and integrated fashions. Here, we performed a pilot study to elucidate space biological mechanisms across tissues by reanalyzing mouse RNA-sequencing spaceflight data archived on NASA GeneLab. Our results showed that clock gene expressions in spaceflight mice were altered compared with those in ground control mice. Furthermore, the results suggested that spaceflight promotes asynchrony of clock gene expressions between peripheral tissues. Abnormal circadian rhythms are associated not only with jet lag and sleep disorders but also with cancer, lifestyle-related diseases, and mental disorders. Overall, our findings highlight the importance of elucidating the causes of circadian rhythm disruptions using the unique approach of space biology research to one day potentially develop countermeasures that benefit humans on Earth and in space.

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Section: Discussionmentioning

confidence: 99%

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight

Fujita

Rutter

Ong

et al. 2020

Life

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“…We know that genetics, heritability, and gender type are major factors that raise the susceptibility to develop T2DM, IR, NAFLD, obesity, and/or other metabolic syndromes [133,134]. While these cannot be changed, factors such as the circadian rhythm that interestingly promotes metabolic disruptions [135,136], lifestyle (exercise, weight loss), and dietary changes can improve clinical and paraclinical outcomes of NAFLD and T2DM on long term [137,138]. More than that, continuous exposure to environmental factors like endocrine-disrupting chemicals such as the ubiquitous phthalates and heavy metals adversely affect human health.…”

Section: Dietary and Lifestylementioning

confidence: 99%

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Tănase

Gosav

Costea

et al. 2020

Journal of Diabetes Research

281

180

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Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.

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“…Microbiota rhythms are regulated by diet and time of feeding which can alter both microbial community structure and metabolic activity that can significantly impact metabolic function [99]. Indeed, an increasing number of circadian rhythm studies have provided important insights correlating the expression of the circadian clock gene with metabolism in NAFLD [100]. However, the exact mechanisms of circadian metabolism remain obscure and unresolved at this time, and clearly require additional experimentation to further increase our comprehension of lipid metabolism in the liver.…”

Section: Future Perspectivesmentioning

confidence: 99%

Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis

Quesada-Vázquez

Aragonès

Bas

et al. 2020

Cells

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Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the world. NAFLD is principally characterized by an excessive fat accumulation in the hepatocytes. Diet is considered as one of the main drivers to modulate the composition of gut microbiota, which participate in different processes, affecting human metabolism. A disruption in the homeostasis of gut microbiota may lead to dysbiosis, which is commonly reflected by a reduction of the beneficial species and an increment in pathogenic microbiota. Gut and liver are in close relation due to the anatomical and functional interactions led by the portal vein, thus altered intestinal microbiota might affect liver functions, promoting inflammation, insulin resistance and steatosis, which is translated into NAFLD. This review will highlight the association between diet, gut microbiota and liver, and how this axis may promote the development of NAFLD progression, discussing potential mechanisms and alterations due to the dysbiosis of gut microbiota. Finally, it will revise the variations in gut microbiota composition in NAFLD, and it will focus in specific species, which directly affect NAFLD progression.

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Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease

Cited by 70 publications

References 81 publications

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis

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