Circadian aspects of mortality in hospitalized patients: A retrospective observation from a large cohort

Abstract

Accumulating evidence has indicated the importance of circadian variations on regulating body functions (e.g., sleep-wake cycle, hormone secretion, blood and temperature regulation, and autonomic nervous tone; Baschieri & Cortelli, 2019;Crnko et al., 2019;Kvaslerud et al., 2010) which plays a great role on disease development. In clinical observation, many cardiovascular diseases (e.g., myocardial infarction, stroke, and arrhythmia) have shown to be closely associated with circadian rhythms (Aronow & Ahn, 2003;Yang et al., 2022). With regard to endogenous rhythms in relation to mortality, sudden cardiac death (SCD) has been mostly studied.Those studies demonstrated that the occurrence of death increases at certain times of the day (Chen & Yang, 2015;Delisle et al., 2021). However, to date, endogenous patterns in relation to mortality of other diseases have rarely been investigated. Whether there is a circadian distribution in overall mortality has yet to be determined.In clinical practice, nurse is the front line of monitoring and treatment for patients, especially for those in intensive care unit (ICU).One study pointed out the importance of research on circadian rhythm and formulated the nursing protocol of identifying circadian health disorders in ICU and hospitalized patients (Padilla-Martínez

Friday excess of overall mortality in three German subpopulations

“…Among these, temporal factors are of particular interest. While monotonically increasing as a function of age, mortality exhibits periodic variations during the annual [1][2][3] and diurnal 4,5 cycle. There is also a sizeable literature on weekly variations of cause-specific mortality, e. g. due to cardiovascular diseases [6][7][8][9][10][11] .…”