Circadian and Sex Differences After Acute High-Altitude Exposure: Are Early Acclimation Responses Improved by Blue Light?

Silva-Urra, Juan; Núñez-Espinosa, Cristián; Méndez, Oscar; Gaitán‐Peñas, Héctor; Altavilla, Cesare; Toro-Salinas, Andrés; Torrella, Joan Ramón; Pagés, Teresa; Javierre, Casimiro; Behn, Claus; Viscor, Ginés

doi:10.1016/j.wem.2015.06.009

Cited by 12 publications

(7 citation statements)

References 64 publications

(82 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polar Team2 Pro (Polar Electro Oy, Kempele, Finland) chest-strapped HR monitors were used to record the children’s inter-beat R-R intervals with millisecond accuracy. The mobile devices for the measurement of R-R intervals by Polar generally show excellent agreement with measurements obtained from electrocardiography (ECG) for both adults [ 52 , 53 , 54 ] and children [ 55 ] (For recent empirical studies in which the Polar Team2 Pro system was applied to dynamically explore heart rate variability (HRV) in different contexts, see Noah et al [ 56 ] and Silva-Urra et al [ 57 ]).…”

Section: Methodsmentioning

confidence: 90%

Stress Response and Cognitive Performance Modulation in Classroom versus Natural Environments: A Quasi-Experimental Pilot Study with Children

Mygind

Stevenson

Liebst

et al. 2018

IJERPH

View full text Add to dashboard Cite

Stress during childhood can have mental and somatic health influences that track throughout life. Previous research attributes stress-reducing effects to natural environments, but has mainly focused on adults and often following leisurely relaxation in natural environments. This pilot study explores the impact of natural environments on stress response during rest and mental load and cognitive performance in 47 children aged 10–12 years in a school context. Heart rate variability measures indexing tonic, event, and phasic vagal tone and attention scores were compared across classroom and natural environments. Tonic vagal tone was higher in the natural environment than the classrooms, but no differences were found in event or phasic vagal tone or cognitive performance measures. These findings suggest a situational aspect of the conditions under which natural environments may give rise to stress-buffering influences. Further research is warranted to understand the potential benefits in a real-life context, in particular with respect to the underpinning mechanisms and effects of accumulated exposure over time in settings where children spend large proportions of time in natural environments.

show abstract

Section: Methodsmentioning

confidence: 90%

Stress Response and Cognitive Performance Modulation in Classroom versus Natural Environments: A Quasi-Experimental Pilot Study with Children

Mygind

Stevenson

Liebst

et al. 2018

IJERPH

View full text Add to dashboard Cite

show abstract

“…Exposure to light at a wavelength between 446 and 477 nm (near blue light in the spectrum, as seen in electronic devices such as tablets or smartphones) suppresses melatonin production during the dark phase of the circadian cycle ( Brainard et al, 2001 ). This phenomenon was evaluated as a potential regulator of the cycle, helping acclimatization during acute exposure to hypoxia ( Silva-Urra et al, 2015 ). In this work, exposure to blue light during simulated hypoxia equivalent to 4,000 m increased systolic blood pressure and improved cognitive performance and alertness, associated with inhibited melatonin production.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Chronic Intermittent Hypobaric Hypoxia on Sleep Quality and Melatonin Serum Levels in Chilean Miners

Calderon-Jofré

Moraga

2022

Front. Physiol.

View full text Add to dashboard Cite

High-altitude mining is an important economic resource for Chile. These workers are exposed to chronic intermittent hypobaric hypoxia (CIHH), which reduces their sleep quality and increases the risk of accidents and long-term illnesses. Melatonin, a hormone produced by the pineal gland, is a sleep inducer that regulates the circadian cycle and may be altered in populations subjected to CIHH. This work aimed to assess the relationship between altitude, sleep quality, and plasma melatonin concentrations in miners with CIHH exposure. 288 volunteers were recruited from five altitudes (0, 1,600, 2,500, 3,500, and 4,500 m). All volunteers worked for 7 days at altitude, followed by 7 days of rest at sea level. We performed anthropometric assessments, nocturnal oximetry, sleep quality and sleepiness surveys, and serum melatonin levels upon awakening. Although oxygen saturation progressively decreased and heart rate increased at higher altitudes, subjective perception of sleep quality was not significantly different, and sleepiness increased in all groups compared to population at sea level. Similarly, melatonin levels increased at all assessed altitudes compared to the population at sea level. These data confirm that sleep disturbances associated with CIHH increase morning melatonin levels. Therefore, this hormone and could potentially serve as a biomarker of sleep quality.

show abstract

“…Many physiological processes that are regulated by circadian rhythms differ between women and men. Therefore, women have higher systolic and diastolic blood pressure at night than men [ 15 ]. Women have a higher heart rate [ 16 ], are more sensitive to sleep disorders than men [ 8 ], and have been shown to have a shorter circadian period than men [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility

Škrlec

Talapko

Juzbašić

et al. 2021

JCDD

View full text Add to dashboard Cite

The growing body of evidence shows a significant difference in the circadian rhythm of cardiovascular disease based on biological sex. The incidence of cardiovascular disease varies between women and men. Additionally, biological sex is vital for the timely application of therapy—chronotherapy, which benefits both sexes. This study aimed to examine the potential difference of single nucleotide polymorphisms (SNPs) of the circadian rhythm genes ARNTL, CLOCK, CRY2 and PER2 in women and men with myocardial infarction. A cross-sectional study was conducted, including 200 patients with myocardial infarction. Altogether, ten single nucleotide polymorphisms in the ARNTL, CLOCK, CRY2 and PER2 genes were analyzed. The Chi-square test yielded statistically significant differences in CLOCK gene rs11932595 polymorphism in a recessive genotype model between women and men with a p-value of 0.03 and an odds ratio 2.66, and a corresponding 95% confidence interval of 1.07 to 6.66. Other analyzed polymorphisms of the circadian rhythm genes ARNTL, CRY2, and PER2 did not significantly differ between the sexes. According to the study’s current results, the CLOCK gene’s genetic variability might affect myocardial infarction concerning biological sex.

show abstract

Circadian and Sex Differences After Acute High-Altitude Exposure: Are Early Acclimation Responses Improved by Blue Light?

Abstract: It remains to be seen whether longer exposure to blue light under hypobaric hypoxic conditions would induce favorable effects against fatigue.

Cited by 12 publications

References 64 publications

Stress Response and Cognitive Performance Modulation in Classroom versus Natural Environments: A Quasi-Experimental Pilot Study with Children

Stress Response and Cognitive Performance Modulation in Classroom versus Natural Environments: A Quasi-Experimental Pilot Study with Children

The Effect of Chronic Intermittent Hypobaric Hypoxia on Sleep Quality and Melatonin Serum Levels in Chilean Miners

Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility

Contact Info

Product

Resources

About