The Effect of Chronic Intermittent Hypobaric Hypoxia on Sleep Quality and Melatonin Serum Levels in Chilean Miners

Calderon-Jofré, Rodrigo; Moraga, Daniel; Moraga, Fernando A.

doi:10.3389/fphys.2021.809360

Cited by 4 publications

(3 citation statements)

References 53 publications

(64 reference statements)

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“…Another interesting factor that could create further insight in the impact of hypoxia and bed rest on sleep is circadian typology (such as melatonin and cortisol secretion measures). In a recent study by Calderon-Jofre et al (2021) , the effect of chronic intermittent hypobaric hypoxia on sleep quality and morning melatonin serum levels in Chilean miners was assessed and an altitude-associated increase in melatonin serum levels was observed. Moreover, an inverse correlation between melatonin concentration and nocturnal oxygen saturation was found ( Calderon-Jofre et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study by Calderon-Jofre et al (2021) , the effect of chronic intermittent hypobaric hypoxia on sleep quality and morning melatonin serum levels in Chilean miners was assessed and an altitude-associated increase in melatonin serum levels was observed. Moreover, an inverse correlation between melatonin concentration and nocturnal oxygen saturation was found ( Calderon-Jofre et al, 2021 ). These findings indicate that altitude-associated impairments in sleep could be related to changes in melatonin levels.…”

Section: Discussionmentioning

confidence: 99%

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Adult Female Sleep During Hypoxic Bed Rest

Cutsem

Pattyn²,

Maîresse³

et al. 2022

Front. Neurosci.

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PurposeHypobaric hypoxic habitats are currently being touted as a potential solution to minimise decompression procedures in preparation for extra vehicular activities during future space missions. Since astronauts will live in hypoxic environments for the duration of such missions, the present study sought to elucidate the separate and combined effects of inactivity [simulated with the experimental bed rest (BR) model] and hypoxia on sleep characteristics in women.MethodsTwelve women (Age = 27 ± 3 year) took part in three 10-day interventions, in a repeated measures cross-over counterbalanced design: (1) normobaric normoxic BR (NBR), (2) normobaric hypoxic BR (HBR; simulated altitude of 4,000 m), and (3) normobaric hypoxic ambulatory (HAMB; 4,000 m) confinement, during which sleep was assessed on night 1 and night 10 with polysomnography. In addition, one baseline sleep assessment was performed. This baseline assessment, although lacking a confinement aspect, was included statistically as a fourth comparison (i.e., pseudo normobaric normoxic ambulatory; pNAMB) in the present study.ResultsHypoxia decreased sleep efficiency (p = 0.019), increased N1% sleep (p = 0.030), decreased N3 sleep duration (p = 0.003), and increased apnea hypopnea index (p < 0.001). BR impaired sleep maintenance, efficiency, and architecture [e.g., N2% sleep increased (p = 0.033)]. Specifically, for N3% sleep, the effects of partial pressure of oxygen and activity interacted. Hypoxia decreased N3% sleep both when active (pNAMB vs HAMB; p < 0.001) and inactive (NBR vs HBR; p = 0.021), however, this decrease was attenuated in the inactive state (–3.8%) compared to the active state (–10.2%).ConclusionA 10-day exposure to hypoxia and BR negatively impacted sleep on multiple levels as in macrostructure, microstructure and respiratory functioning. Interestingly, hypoxia appeared to have less adverse effects on sleep macrostructure while the participants were inactive (bed ridden) compared to when ambulatory. Data were missing to some extent (i.e., 20.8%). Therefore, multiple imputation was used, and our results should be considered as exploratory.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Adult Female Sleep During Hypoxic Bed Rest

Cutsem

Pattyn²,

Maîresse³

et al. 2022

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Hypoxia increases sleep disturbances particularly in women which apparently increases even more when combined with bed rest applied as a quasi-weightlessness condition to simulate spacecraft and/or planetary environments ( Morrison et al, 2017 ; Van Cutsem et al, 2022 ). Nocturnal oxygen saturation inversely relates to serum melatonin concentration, at least in males ( Calderón-Jofré et al, 2021 ), suggesting that melatonin may also be involved in altitude-associated sleep impairments. Sleep issues are strongly linked to psychiatric disorders ( Benca, 1992 ; Wetter et al, 2008 ).…”

Section: Special Topicsmentioning

confidence: 99%

Women’s mood at high altitude. sexual dimorphism in hypoxic stress modulation by the tryptophan–melatonin axis

et al. 2023

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Sexual (and gender)-dimorphism in tolerance to hypobaric hypoxia increasingly matters for a differential surveillance of human activities at high altitude (HA). At low altitudes, the prevalence of anxiety and depression in women has already been found to double when compared with men; it could be expected to even increase on exposure to HA. In purposefully caring for the health of women at HA, the present work explores the potential involvement of the tryptophan (Trp)–melatonin axis in mood changes on exposure to hypobaric hypoxia. The present work highlights some already known anxiogenic effects of HA exposure. Hypoxia and insomnia reduce serotonin (5-HT) availability; the latter defect being expressed as failure of brown adipose tissue (BAT) activation and mood disorders. Rapid eye movement (REM) sleep organization and synapsis restoration that are additionally affected by hypoxia impair memory consolidation. Affective complaints may thus surge, evolving into anxiety and depression. Sex-related differences in neural network organization and hormonal changes during the menstrual cycle, and certainly also during the life cycle, underscore the possibility of 5-HT–related mood alterations, particularly in women on HA exposure. The mean brain rate of 5-HT synthesis at sea level is already 1.5-fold higher in males than in females. sexual dimorphism also evidences the overexpression effects of SERT, a 5-HT transporter protein. Gonadal and thyroid hormones, as influenced by HA exposure, further modulate 5-HT availability and its effects in women. Besides caring for adequate oxygenation and maintenance of one’s body core temperature, special precautions concerning women sojourning at HA should include close observations of hormonal cycles and, perhaps, also trials with targeted antidepressants.

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A narrative review of periodic breathing during sleep at high altitude: From acclimatizing lowlanders to adapted highlanders

Patrician,

Anholm,

Ainslie

2024

The Journal of Physiology

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Periodic breathing during sleep at high altitude is almost universal among sojourners. Here, in the context of acclimatization and adaptation, we provide a contemporary review on periodic breathing at high altitude, and explore whether this is an adaptive or maladaptive process. The mechanism(s), prevalence and role of periodic breathing in acclimatized lowlanders at high altitude are contrasted with the available data from adapted indigenous populations (e.g. Andean and Tibetan highlanders). It is concluded that (1) periodic breathing persists with acclimatization in lowlanders and the severity is proportional to sleeping altitude; (2) periodic breathing does not seem to coalesce with poor sleep quality such that, with acclimatization, there appears to be a lengthening of cycle length and minimal impact on the average sleeping oxygen saturation; and (3) high altitude adapted highlanders appear to demonstrate a blunting of periodic breathing, compared to lowlanders, comprising a feature that withstands the negative influences of chronic mountain sickness. These observations indicate that periodic breathing persists with high altitude acclimatization with no obvious negative consequences; however, periodic breathing is attenuated with high altitude adaptation and therefore potentially reflects an adaptive trait to this environment. image

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The Effect of Chronic Intermittent Hypobaric Hypoxia on Sleep Quality and Melatonin Serum Levels in Chilean Miners

Cited by 4 publications

References 53 publications

Adult Female Sleep During Hypoxic Bed Rest

Adult Female Sleep During Hypoxic Bed Rest

Women’s mood at high altitude. sexual dimorphism in hypoxic stress modulation by the tryptophan–melatonin axis

A narrative review of periodic breathing during sleep at high altitude: From acclimatizing lowlanders to adapted highlanders

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