circ_0101802 functions as a sponge of miR-1236-3p to facilitate the proliferation, migration and invasion of colorectal cancer via regulating MACC1

Bai, Liang; Gao, Zhifeng; Jiang, An; Ren, Shengxiang; Wang, Baotai

doi:10.1016/j.jphs.2021.06.002

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…Moreover, miR-1236-3p was downregulated in CRC tissues and reversed the carcinogenic effects of circRNA_103948 on cell functions, acting as a tumor suppressor. These findings are consistent with those of Feng et al and Bai et al 15,16 Besides the role of miR-1236-3p in CRC, there have been emerging evidence indicating that miR-1236-3p could inhibit tumorigenesis in lung, bladder, and ovarian cancer, cutaneous squamous cell carcinoma, and gastric cancer, suggesting that miR-1236-3p plays an essential role in cancer and deserves more attention in the translation into clinical application. [17][18][19][20][21] We further identified TPT1 as a direct target of miR-1236-3p in CRC cells.…”

Section: R E T R a C T E Dsupporting

confidence: 91%

“…These findings are consistent with those of Feng et al . and Bai et al 15,16 . Besides the role of miR‐1236‐3p in CRC, there have been emerging evidence indicating that miR‐1236‐3p could inhibit tumorigenesis in lung, bladder, and ovarian cancer, cutaneous squamous cell carcinoma, and gastric cancer, suggesting that miR‐1236‐3p plays an essential role in cancer and deserves more attention in the translation into clinical application 17–21 …”

Section: Discussionmentioning

confidence: 99%

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Retracted: CircRNA_103948 inhibits autophagy in colorectal cancer in a ceRNA manner

Zhang

et al. 2021

Annals of the New York Academy of Sciences

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Circular RNA (circRNA) is implicated in many types of cancer; however, the expression and role of circRNAs in colorectal cancer (CRC) remains poorly understood. In this study, a circRNA microarray assay was performed to detect abnormally expressed circRNAs in CRC, and tissue arrays were used to determine the prognosis for CRC patients. Cell counting kit‐8, clone formation, wound healing, and transwell assays were used to evaluate cell functions in vitro, and a mouse subcutaneous tumor model was designed for in vivo analysis. Autophagy was observed using confocal laser scanning and transmission electron microscopy. The expression of circRNA, miRNA, and mRNA was detected using qPCR; western blot, RNA pull‐down assay, RNA immunoprecipitation, and dual luciferase assessment were applied for mechanistic studies. We found that circRNA_103948 expression is upregulated in CRC tissues, compared with adjacent normal tissues, and associated with poor prognosis. Knockdown of circRNA_103948 suppressed CRC both in vitro and in vivo. Mechanistically, circRNA_103948 could directly bind to miR‐1236‐3p and relieve suppression of the target TPT1. Furthermore, circRNA_103948 inhibited autophagy of CRC cells. Taken together, circRNA_103948 knockdown inhibited CRC cell growth by targeting miR‐1236‐3p/TPT1 axis–mediated autophagy. Thus, the circRNA_103948/miR‐1236‐3p/TPT1 axis affects CRC progression via modulation of autophagy.

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Section: R E T R a C T E Dsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Retracted: CircRNA_103948 inhibits autophagy in colorectal cancer in a ceRNA manner

Zhang

et al. 2021

Annals of the New York Academy of Sciences

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“…MiR-1236 had been shown to participate in regulating the progression of inflammatory lymphangiogenesis and osteoarthritis [ 32 , 33 ]. It was reported that miR-1236-3p played a tumor suppresser role in many cancer development, including colorectal cancer [ 34 , 35 ]. Consistent with the previously research [ 19 ], we confirmed that miR-1236-3p had a decreased expression in UC patients.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA_0001187 participates in the regulation of ulcerative colitis development via upregulating myeloid differentiation factor 88

Ouyang

et al. 2022

Bioengineered

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Circular RNA (circRNA) had been confirmed to participate in ulcerative colitis (UC) development. Circular RNA_0001187 (Circ_0001187) had been found to be overexpressed in patients with Crohn disease. Therefore, circ_0001187 might be an important circRNA regulating intestinal inflammatory diseases. However, the role and mechanism of circ_0001187 in UC progression remains unclear. The colonic mucosal tissues were obtained from 23 UC patients and 23 healthy normal controls. Tumor necrosis factor-α (TNF-α) was used to mimic UC cell model in vitro . Cell function was assessed by cell counting kit 8 assay, EdU assay, flow cytometry, ELISA assay and oxidative stress detection. RNA interaction was confirmed by dual-luciferase reporter assay and RIP assay. Serum exosomes were isolated by ultracentrifugation and identified by transmission electron microscope. Circ_0001187 was overexpressed in UC patients. Circ_0001187 knockdown enhanced the proliferation, while suppressed apoptosis, inflammation and oxidative stress of TNF-α-induced FHC cells. Circ_0001187 acted as miR-1236-3p sponge, and the effects of circ_0001187 downregulation on TNF-α-induced FHC cell injury were overturned by miR-1236-3p inhibitor. MYD88 was targeted by miR-1236-3p, and circ_0001187 sponged miR-1236-3p to regulate MYD88. MYD88 knockdown alleviated TNF-α-induced FHC cell injury, and its upregulation revoked the inhibition effect of miR-1236-3p on TNF-α-induced FHC cell injury. High expression of circ_0001187 also was observed in the serum exosomes of UC patients. Our data confirmed that circ_0001187 facilitated UC progression through miR-1236-3p/MYD88 axis, which might be a potential treatment and diagnosis biomarker for UC.

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“…The (sub-) structures formed by each of those elements are not independent, but coupled, increasing the complexity of the system (17). For this review, we will focus on microtubules and actin due to their crucial role in cell migration and on vimentin as it was often found to be regulated by MACC1 (32)(33)(34)(35).…”

Section: The Cytoskeletonmentioning

confidence: 99%

“…Looking further downstream, MACC1 was frequently found to induce a mesenchymal phenotype in multiple tumor types, through the measurement of EMT markers, such as increased expression of vimentin and N-cadherin and reduced expression of E-cadherin ( 32 – 34 , 166 , 169 , 170 , 182 , 203 , 211 – 213 ). Yet, the intracellular organization of the vimentin cytoskeleton does not appear to be altered in glioblastoma cells upon MACC1 overexpression ( 13 ).…”

Section: Macc1 In Tumor Migrationmentioning

confidence: 99%

MACC1-induced migration in tumors: Current state and perspective

2023

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Malignant tumors are still a global, heavy health burden. Many tumor types cannot be treated curatively, underlining the need for new treatment targets. In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor migration, initiation, proliferation, and others in a multitude of solid cancers. Here, we will summarize the current knowledge about MACC1-induced tumor cell migration with a special focus on the cytoskeletal and adhesive systems. In addition, a brief overview of several in vitro models used for the analysis of cell migration is given. In this context, we will point to issues with the currently most prevalent models used to study MACC1-dependent migration. Lastly, open questions about MACC1-dependent effects on tumor cell migration will be addressed.

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circ_0101802 functions as a sponge of miR-1236-3p to facilitate the proliferation, migration and invasion of colorectal cancer via regulating MACC1

Cited by 6 publications

References 28 publications

Retracted: CircRNA_103948 inhibits autophagy in colorectal cancer in a ceRNA manner

Retracted: CircRNA_103948 inhibits autophagy in colorectal cancer in a ceRNA manner

Circular RNA_0001187 participates in the regulation of ulcerative colitis development via upregulating myeloid differentiation factor 88

MACC1-induced migration in tumors: Current state and perspective

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