Circ_0059457 Promotes Proliferation, Metastasis, Sphere Formation and Glycolysis in Breast Cancer Cells by Sponging miR-140-3p to Regulate UBE2C

Huang, Li; Zhang, Guochen; Han, Li; Bai, Xuejuan; Xi, Zhibin; Wang, Fan; Han, Guohui

doi:10.1007/s10528-023-10407-8

Cited by 3 publications

(1 citation statement)

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“…UBE2C is also associated with cell cycle-related biomarkers, such as p53, ki67, EGFR, and PI3K, and its overexpression reduces sensitivity to chemotherapy [59,60]. More recently, it has been reported that the circular RNA circ_0059457 is responsible for UBE2C-driven breast cancer cell migration, invasion, and metastasis through an miR-140-3p-dependent mechanism [84].…”

Section: Breast Cancermentioning

confidence: 99%

Role of UBE2C in Brain Cancer Invasion and Dissemination

Domentean,

Paisana,

Cascão

et al. 2023

IJMS

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Glioblastoma (GB) and brain metastases (BM) are the most common brain tumors in adults and are invariably associated with a dismal outcome. These highly malignant tumors share common features including increased invasion and migration of the primary or metastatic brain cancer cells, whose triggering mechanisms are largely unknown. Emerging evidence has suggested that the ubiquitin-conjugating enzyme E2C (UBE2C), essential for controlling cell cycle progression, is overexpressed in diverse malignancies, including brain cancer. This review highlights the crucial role of UBE2C in brain tumorigenesis and its association with higher proliferative phenotype and histopathological grade, with autophagy and apoptosis suppression, epithelial-to-mesenchymal transition (EMT), invasion, migration, and dissemination. High expression of UBE2C has been associated with patients’ poor prognosis and drug resistance. UBE2C has also been proven as a promising therapeutic target, despite the lack of specific inhibitors. Thus, there is a need to further explore the role of UBE2C in malignant brain cancer and to develop effective targeted therapies for patients with this deadly disease.

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Section: Breast Cancermentioning

confidence: 99%

Role of UBE2C in Brain Cancer Invasion and Dissemination

Domentean,

Paisana,

Cascão

et al. 2023

IJMS

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Synthesis of 2‐phenylnaphthalenoid amide derivatives and their topoisomerase IIα inhibitory and antiproliferative activities

Wu,

Xu,

et al. 2024

Archiv der Pharmazie

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Topoisomerases are highly associated with cell proliferation, becoming an important target for the development of antitumor drugs. 2‐Phenylnaphthalenoids (2PNs) have been identified as human DNA topoisomerase IIα (TopoIIα) inhibitors. In this study, based on the 2PN scaffold, 20 amide derivatives (J1–J10, K1–K10) were synthesized. Among them, K10 showed high TopoIIα inhibitory activity and stronger antiproliferation activity against HepG‐2 and MDA‐MB‐231 cells (IC50 0.33 and 0.63 μM, respectively) than the positive control VP‐16 (IC50 9.19 and 10.86 μM) and the lead F2 (IC50 0.64 and 1.51 μM). Meanwhile, K10 could also inhibit migration and promote apoptosis of HepG‐2 and MDA‐MB‐231 cells. Therefore, K10 can be developed into a potent TopoIIα inhibitor as an antitumor agent. The structure–activity relationship was also discussed.

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