Ciprofloxacin Therapy of Mycobacterium chelonae Keratitis

Nontuberculous (Atypical) Mycobacterial Keratitis After LASIK

“…89 However, the clinical efficacy of ciprofloxacin against NTM keratitis has varied. [125][126][127] Resistance is an emerging problem with these drugs, and up to 60% of NTM keratitis was unresponsive to amikacin and even a higher percentage was unresponsive to ciprofloxacin. 111 This has led to the use of clarithromycin 5,6,11,111 and azithromycin 4 to treat NTM keratitis.…”

Mycobacterium chelonae–Mycobacterium abscessus complex clear corneal wound infection with recurrent hypopyon and perforation after phacoemulsification and intraocular lens implantation

“…[25][26][27] Culture of the corneal wound may require biopsy, histopathologic examination, and the use of media suitable for the isolation of mycobacterial or fungal organisms in cases in which more traditional bacterial culturing techniques have failed. The delay in diagnosis or treatment of this opportunistic infection can lead to vision loss or the need for additional surgical interventions.…”

Management of bacterial keratitis: beyond exorcism towards consideration of organism and host factors

“…The MICs of ofloxacin have ranged from 0.03 to 1.2 mg/ml and no resistant strains have been identified. Experimental animal models and isolated clinical reports 108 have suggested that topical ciprofloxacin alone or in combination with topical amikacin may be useful in the treatment of M. fortuitum keratitis. Experimental studies assessing the in vivo efficacy of newer macrolides, including clarithromycin and azithromycin, 109,110 suggest a potential role in the therapy of M. fortuitum keratitis.…”