Ciprofloxacin monoolein water gels as implants for the treatment of chronic osteomyelitis: In vitro characterization

Abstract

This work investigated the possibility of using the biodegradable gentamicin-monoolein-water gels as models, in order to obtain a similar sustained release of ciprofloxacin hydrochloride. Four gels containing antibiotics were prepared and were examined with regard to their physicochemical properties and in vitro drug release characteristics. Ciprofloxacin, unlike gentamicin, which was dissolved in the matrix, was in dispersed form. However, despite its insolubility, microscopic observation, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and X-ray diffraction showed that the developed gel was in the cubic liquid crystalline structure and have maintained their ability to progressively release ciprofloxacin. ciprofloxacin-monoolein-water (5:80:15% w/w), which released in vitro approximately 85% of ciprofloxacin after 16 days could possibly be considered as an alternative to a gentamicin-monoolein-water gel for the treatment of chronic osteomyelitis.

Physicochemical characterization and antimicrobial evaluation of gentamicin-loaded CaCO3 nanoparticles prepared via microemulsion method

“…No endo/exothermic peak was detected for GS-loaded CaCO 3 nanoparticles up to 350 °C (curves D) signifying that the drug was incorporated into the nanoparticles in an amorphous form. Similar observations have been reported by other authors for GS-loaded gels [62,67]. …”

“…According to curve (D), PXRD studies indicated that GS was loaded in its amorphous form into CaCO 3 nanoparticles during the precipitation (curve D). Similar observations have been reported by Sombie et al [67] and Semde et al [62] for GS-loaded gels. Figure 6.…”

“…Figure 6. Due to the amorphous nature of GS, no melting point was observed in its thermogram (curve A) [62,67]. The endothermic peak at about 100 °C for pure GS and its physical mixture with CaCO 3 nanoparticles was ascribed to the removal of physisorbed and chemisorbed water molecules [62,68].…”

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

“…The ability to incorporate hydrophobic, hydrophilic, and amphiphilic compounds, the capacity to protect and safe deliver molecules, and the tortuous internal configuration that allows a sustained release are a few examples of features that make cubosomes particles with such great potential. From therapeutics to imaging, or even a combination of both, innumerable applications have been proposed regarding the use of cubosomes in the biomedical field, such as in cancer [132], infection [133], or even cerebrovascular disorders [64]. In this review, some examples are presented.…”