Ciprofloxacin-encapsulated poly(dl-lactide-co-glycolide) nanoparticles and its antibacterial activity

Jeong, Young‐Il; Na, Hee-Sam; Seo, Donghyuk; Kim, Dong-Gon; Lee, Hyun Chul; Jang, Mi-Kyeong; Na, Sang-Kwon; Roh, Sung‐Hee; Kim, Sunil; Nah, Jae‐Woon

doi:10.1016/j.ijpharm.2007.11.001

Cited by 120 publications

(70 citation statements)

References 18 publications

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“…27 It is the most widely used fluoroquinolone for bacterial bone infections and has potent bactericidal activity against a broad range of clinically relevant Gram-negative and Gram-positive pathogens. 28 The minimum inhibitory concentration (MIC) of CIP is as low as 0.25-1 µg/mL for Staphylococcus (frequently found in osteomyelitis). 29 Although the usual dosage of CIP is 750 mg twice daily for periods ranging from 6 weeks to several months, the cure rate is only ∼56%.…”

Section: Introductionmentioning

confidence: 99%

Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles

Sirivisoot¹,

Harrison²

2015

IJN

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To extend the external control capability of drug release, iron oxide nanoparticles (NPs) encapsulated into polymeric microspheres were used as magnetic media to stimulate drug release using an alternating magnetic field. Chemically synthesized iron oxide NPs, maghemite or hematite, and the antibiotic ciprofloxacin were encapsulated together within polycaprolactone microspheres. The polycaprolactone microspheres entrapping ciprofloxacin and magnetic NPs could be triggered for immediate drug release by magnetic stimulation at a maximum value of 40%. Moreover, the microspheres were cytocompatible with fibroblasts in vitro with a cell viability percentage of more than 100% relative to a nontreated control after 24 hours of culture. Macrophage cell cultures showed no signs of increased inflammatory responses after in vitro incubation for 56 hours. Treatment of Staphylococcus aureus with the magnetic microspheres under an alternating (isolating) magnetic field increased bacterial inhibition further after 2 days and 5 days in a broth inhibition assay. The findings of the present study indicate that iron oxide NPs, maghemite and hematite, can be used as media for stimulation by an external magnetic energy to activate immediate drug release.

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Section: Introductionmentioning

confidence: 99%

Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles

Sirivisoot¹,

Harrison²

2015

IJN

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“…In this regard, several studies have reported that a sustained antibiotic release profile from carrier particles results in higher antibacterial efficacies against both planktonic and biofilm cells than those obtained from the faster release profile in the free-drug formulations (11,(25)(26)(27). The superiority of the sustained release profile observed in these studies, however, is attributed more to the immediate clearance of the antibiotic in the free-drug formulations or, in the case of Misra et al (27), the deactivation of the antibacterial activity of the free-drug formulation upon its administration that necessitates its encapsulation, rather than the effect of having a sustained antibiotic concentration on the bacterial cell defensive response.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Efficacy of Inhalable Levofloxacin-Loaded Polymeric Nanoparticles Against E. coli Biofilm Cells: The Effect of Antibiotic Release Profile

2010

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“…The pure drug gradually loses its effect after 24 h and bacteria that escaped drug action can multiply at a faster rate when given suitable conditions. Therefore, a sustained release formulation is required that can control the growth of bacteria for a longer period of time (Jeong et al, 2008). A significant decrease in the MBC values of DNPs was observed in comparison to control (p50.01) after 24 h. It is worth mentioning that MIC and MBC values in DNPs were less than that of aqueous solution of DXY in our study.…”

Section: Discussionmentioning

confidence: 56%

Engineering of polymer–surfactant nanoparticles of doxycycline hydrochloride for ocular drug delivery

Pokharkar¹,

Patil²,

Mandpe³

2014

Drug Delivery

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Context: Physiologic barriers of the eye, short precorneal drug residence time and poor corneal penetration are the few reasons for reduced ocular bioavailability. Objective: This study was aimed to develop novel polymer-surfactant nanoparticles of hydrophilic drug doxycycline hydrochloride (DXY) to improve precorneal residence time and drug penetration. Materials and methods: Nanoparticles were formulated using emulsion cross-linking method and the formulation was optimized using factorial design. The prepared formulation was characterized for particle size, potential, encapsulation efficiency, in vitro drug release and ex vivo drug diffusion studies. The antibacterial activity studies were also carried out against Escherichia coli and Staphylococcus aureus using the cup-plate method. In vivo eye irritation study was carried out by a modified Draize test in rabbits. Results and discussion: The particle size was found to be in the range of 331-850 nm. About 45-80% of the drug was found to be encapsulated in the nanoparticles. In vitro release demonstrated sustained release profile. Lower flux values in case of nanoparticles as compared to DXY pure drug solution in ex vivo diffusion studies confirmed the sustained release. The nanoparticles were found to be significantly effective (p50.001) than DXY aqueous solution due to sustained release of doxycycline from nanoparticles in both the E. coli and S. aureus strains. The formulation was found to be stable over entire stability period. Conclusion: The developed formulation is safe and suitable for sustained ocular drug delivery.

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Ciprofloxacin-encapsulated poly(dl-lactide-co-glycolide) nanoparticles and its antibacterial activity

Cited by 120 publications

References 18 publications

Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles

Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles

Antibacterial Efficacy of Inhalable Levofloxacin-Loaded Polymeric Nanoparticles Against E. coli Biofilm Cells: The Effect of Antibiotic Release Profile

Engineering of polymer–surfactant nanoparticles of doxycycline hydrochloride for ocular drug delivery

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Ciprofloxacin-encapsulated poly(dl-lactide-co-glycolide) nanoparticles and its antibacterial activity

Cited by 120 publications

References 18 publications

Magnetically stimulated ciprofloxacin release from&nbsp;polymeric microspheres entrapping iron oxide nanoparticles

Magnetically stimulated ciprofloxacin release from&nbsp;polymeric microspheres entrapping iron oxide nanoparticles

Antibacterial Efficacy of Inhalable Levofloxacin-Loaded Polymeric Nanoparticles Against E. coli Biofilm Cells: The Effect of Antibiotic Release Profile

Engineering of polymer–surfactant nanoparticles of doxycycline hydrochloride for ocular drug delivery

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Product

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Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles

Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles