Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming

Jiang, Juan; Emont, Margo P.; Jun, Hee-Jin; Qiao, Xuguang; Liao, Jia‐Feng; Kim, Dong il; Wu, Jun

doi:10.1016/j.metabol.2017.08.006

Cited by 57 publications

(44 citation statements)

References 19 publications

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“…Contrarious to our data, cinnamon extract in IgE-stimulated human intestinal mast cells was reported to attenuate p38 phosphorylation 63 and p38 phosphorylation was significantly reduced in THP-1derived macrophages after treatment with trans-cinnamaldhyde, 28 whereas cinnamaldehyde was shown to induce phosphorylation of p38 in murine inguinal adipocytes. 64 In a LPSinduced acute lung injury mouse model, p-cymene revealed a dose-dependent significant mitigation of p38 phosphorylation. 54 Interestingly, the reported decrease of phospho-IκBα/ IκBα protein ratio after p-cymene treatment in the same study has been in line with our data.…”

Section: Food and Function Papermentioning

confidence: 97%

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

et al. 2018

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Section: Food and Function Papermentioning

confidence: 97%

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

et al. 2018

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“…Going beyond the ability of spices to act as flavoring and antimicrobial agents [2], our studies show the broad-spectrum benevolence of spices through analysis of empirical data. Recent studies have shown the potential benefits of consumption of spices such as chillies through cohort studies [44] as well as the role of specific spice phytochemicals in their health effects [45]. Interestingly, the broad-spectrum benevolence score of a spice was not positively correlated with its phytochemical repertoire (S2 Fig) suggesting that richness in the phytochemical content itself does not explain its therapeutic value.…”

Section: Discussionmentioning

confidence: 99%

Data-driven analysis of biomedical literature suggests broad-spectrum benevolence of culinary herbs and spices

Rakhi

Tuwani

Mukherjee

et al. 2018

Preprint

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in ¶ These authors contributed equally to this work. AbstractSpices and herbs are key dietary ingredients used across cultures worldwide. Beyond their use as flavoring and coloring agents, the popularity of these aromatic plant products in culinary preparations has been attributed to their antimicrobial properties. Last few decades have witnessed an exponential growth of biomedical literature investigating the impact of spices and herbs on health, presenting an opportunity to mine for patterns from empirical evidence. Systematic investigation of empirical evidence to enumerate the health consequences of culinary herbs and spices can provide valuable insights into their therapeutic utility. We implemented a text mining protocol to assess the health impact of spices by assimilating, both, their positive and negative effects. We conclude that spices show broad-spectrum benevolence across a range of disease categories in contrast to negative effects that are comparatively narrow-spectrum. We also implement a strategy for disease-specific culinary recommendations of spices based on their therapeutic tradeoff against adverse effects. Further by integrating spice-phytochemical-disease associations, we identify bioactive spice phytochemicals potentially involved in their therapeutic effects. Our study provides a systems perspective on health effects of culinary spices and herbs with applications for dietary recommendations as well as identification of phytochemicals potentially involved in underlying molecular mechanisms. 2 Author SummarySpices and herbs are among the important ingredients in culinary preparations whose evolutionary utility is debatable. While their proximate function could be largely due to their flavor, the ultimate reason for their widespread incorporation in traditional recipes is hitherto not well understood. We implemented a computational framework for integrating spice-disease associations compiled from biomedical literature and evidence linking spice phytochemicals with diseases. By mining these tripartite data we highlight broad-spectrum therapeutic effects of spices to provide informed culinary recommendations against disease categories and seek for their potential molecular mechanisms. Through data-driven investigations, our study thus provides evidence-based applications of spices from culinary as well as medicinal perspectives.

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“…In rats, cinnamon-linked increased rate of cold adaptive thermogenesis was due to the elevation in norepinephrine, blood levels of free fatty acid levels and increased expression of UCP1 in BAT [142]. Experimental studies have reported the ability of cinnamaldehyde in activating phospho-AMPK in adipose tissue [140], enhancing thermogenic and metabolic responses in human subcutaneous fat cells through a cAMP dependent protein kinase/p38 mitogen-activated protein kinase (p38 MAPK)-dependent pathway (involved in the transcription of thermogenic genes) [143] and inducing browning in mice subcutaneous adipocytes by increased expressions of UCP1 and other brown adipocyte markers and involvement of the β3-adrenoreceptor activity [144]. Finally, cinnamaldehyde has been shown to activate the transient receptor potential ankyrin 1 (TRPA1), an ion channel located at the cellular surface, acting as a mechanical and chemical stress sensor, which is involved in adrenalin secretion [145].…”

Section: Molecular Mechanisms Of Actionmentioning

confidence: 99%

A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

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The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure.

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Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming

Cited by 57 publications

References 19 publications

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

Data-driven analysis of biomedical literature suggests broad-spectrum benevolence of culinary herbs and spices

A Critical Review on the Role of Food and Nutrition in the Energy Balance

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