Cingulate cortex function and multi-modal connectivity mapped using intracranial stimulation

Oane, Irina; Barborică, Andrei; Chetan, Filip; Donos, Cristian; Mălîia, Mihai Dragoş; Arbune, Anca Adriana; Daneasa, Andrei; Pistol, Constantin; Nica, Adriana Elena; Băjenaru, Ovidiu; Mı̂ndruță, Ioana

doi:10.1016/j.neuroimage.2020.117059

Cited by 60 publications

(105 citation statements)

References 75 publications

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“…The amygdala targets the subgenual and pregenual parts of the anterior cingulate cortex (sACC and pACC, respectively) via the uncinate fasciculus, and cingulate regions are interconnected via the cingulate bundle (Dejerine 1895 ). The two ACC regions and the anterior midcingulate cortex (aMCC) monitor sensory stimuli, whereby ACC areas monitor emotional stimuli with respect to their pleasantness or unpleasantness (Oane et al 2020 ; Palomero-Gallagher et al 2015 , 2019 ; Vogt and Miller 1983 ), and areas of the aMCC region play a crucial role in both the perception and anticipation of pain (Porro and Lui 2009 ; Vogt et al 1996 ; Vogt and Sikes 2009b ).…”

Section: Brain Regions Subserving Emotionmentioning

confidence: 99%

A short review on emotion processing: a lateralized network of neuronal networks

Palomero-Gallagher

Amunts

2021

Brain Struct Funct

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Emotions are valenced mental responses and associated physiological reactions that occur spontaneously and automatically in response to internal or external stimuli, and can influence our behavior, and can themselves be modulated to a certain degree voluntarily or by external stimuli. They are subserved by large-scale integrated neuronal networks with epicenters in the amygdala and the hippocampus, and which overlap in the anterior cingulate cortex. Although emotion processing is accepted as being lateralized, the specific role of each hemisphere remains an issue of controversy, and two major hypotheses have been proposed. In the right-hemispheric dominance hypothesis, all emotions are thought to be processed in the right hemisphere, independent of their valence or of the emotional feeling being processed. In the valence lateralization hypothesis, the left is thought to be dominant for the processing of positively valenced stimuli, or of stimuli inducing approach behaviors, whereas negatively valenced stimuli, or stimuli inducing withdrawal behaviors, would be processed in the right hemisphere. More recent research points at the existence of multiple interrelated networks, each associated with the processing of a specific component of emotion generation, i.e., its generation, perception, and regulation. It has thus been proposed to move from hypotheses supporting an overall hemispheric specialization for emotion processing toward dynamic models incorporating multiple interrelated networks which do not necessarily share the same lateralization patterns.

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Section: Brain Regions Subserving Emotionmentioning

confidence: 99%

A short review on emotion processing: a lateralized network of neuronal networks

Palomero-Gallagher

Amunts

2021

Brain Struct Funct

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“…Several studies (Beckmann et al 2009 ; Yu et al 2011 ; Jin et al 2018 ) have examined the connectivity of the human cingulate regions with structural methods, in which diffusion-weighted MR images are used to track white-matter pathways, and/or resting state functional MRI, in which correlations in spontaneous activity at rest between brain regions are assumed to reflect connectivity. One recent study (Oane et al 2020 ) has even used intracranial stimulation to track cingulate connections. The emphasis in these studies was on parcellation of the cingulate into zones based on shared connectivity within zones and differing connectivity between zones.…”

Section: Connectivity Of Human and Macaque Csv (Mri)mentioning

confidence: 99%

Cortical visual area CSv as a cingulate motor area: a sensorimotor interface for the control of locomotion

Smith

2021

Brain Struct Funct

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The response properties, connectivity and function of the cingulate sulcus visual area (CSv) are reviewed. Cortical area CSv has been identified in both human and macaque brains. It has similar response properties and connectivity in the two species. It is situated bilaterally in the cingulate sulcus close to an established group of medial motor/premotor areas. It has strong connectivity with these areas, particularly the cingulate motor areas and the supplementary motor area, suggesting that it is involved in motor control. CSv is active during visual stimulation but only if that stimulation is indicative of self-motion. It is also active during vestibular stimulation and connectivity data suggest that it receives proprioceptive input. Connectivity with topographically organized somatosensory and motor regions strongly emphasizes the legs over the arms. Together these properties suggest that CSv provides a key interface between the sensory and motor systems in the control of locomotion. It is likely that its role involves online control and adjustment of ongoing locomotory movements, including obstacle avoidance and maintaining the intended trajectory. It is proposed that CSv is best seen as part of the cingulate motor complex. In the human case, a modification of the influential scheme of Picard and Strick (Picard and Strick, Cereb Cortex 6:342–353, 1996) is proposed to reflect this.

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“…According to the structure and function, the cingulate can be subdivided into several parts, in which the middle cingulate cortex is considered to be related to the function of the Frontoparietal Network (Vincent et al, 2008;Gilmore et al, 2015;Caruana et al, 2018). Specifically, the middle cingulate cortex is associated with emotion, behavior, motor, and somatosensory function; and has a close functional connection with prefrontal, premotor, and primary motor networks (Oane et al, 2020). Compared with the elderly with MCI, the elderly with normal cognition had a better connection between the middle cingulate and the superior frontal gyrus, frontal eye field, orbitofrontal cortex (Cera et al, 2019).…”

Section: Similar Pattern Between the Obj-scd And Amci Groupsmentioning

confidence: 99%

Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle Cognitive Decline

Cui

Zhang

et al. 2021

Front. Aging Neurosci.

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Introduction: To identify individuals with preclinical cognitive impairment, researchers proposed the concept of objectively-defined subtle cognitive decline (Obj-SCD). However, it is not clear whether Obj-SCD has characteristic brain function changes. In this study, we aimed at exploring the changing pattern of brain function activity in Obj-SCD individuals and the similarities and differences with mild cognitive impairments (MCI).Method: 37 healthy control individuals, 25 Obj-SCD individuals (with the impairment in memory and language domain), and 28 aMCI individuals were included. Resting-state fMRI and neuropsychological tests were performed. fALFF was used to reflect the local functional activity and compared between groups. Finally, we analyzed the correlation between the fALFF values of significantly changed regions and neuropsychological performance.Results: We found similar functional activity enhancements in some local brain regions in the Obj-SCD and aMCI groups, including the left orbital part of the inferior frontal gyrus and the left median cingulate and paracingulate gyri. However, some changes in local functional activities of the Obj-SCD group showed different patterns from the aMCI group. Compared with healthy control (HC), the Obj-SCD group showed increased local functional activity in the right middle occipital gyrus, decreased local functional activity in the left precuneus and the left inferior temporal gyrus. In the Obj-SCD group, in normal band, the fALFF value of the right middle occipital gyrus was significantly negatively correlated with Mini-Mental State Examination (MMSE) score (r = −0.450, p = 0.024) and Animal Verbal Fluency Test (AFT) score (r = −0.402, p = 0.046); the left inferior temporal gyrus was significantly positively correlated with MMSE score (r = 0.588, p = 0.002). In slow-4 band, the fALFF value of the left precuneus was significantly positively correlated with MMSE score (r = 0.468, p = 0.018) and AFT score (r = 0.600, p = 0.002). In the aMCI group, the fALFF value of the left orbital part of the inferior frontal gyrus was significantly positively correlated with Auditory Verbal Learning Test (AVLT) long delay cued recall score (r = 0.506, p = 0.006).Conclusion: The Obj-SCD group showed a unique changing pattern; the functional changes of different brain regions have a close but different correlation with cognitive impairment, indicating that there may be a complex pathological basis inside. This suggests that Obj-SCD may be a separate stage of cognitive decline before aMCI and is helpful to the study of preclinical cognitive decline.

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Cingulate cortex function and multi-modal connectivity mapped using intracranial stimulation

Cited by 60 publications

References 75 publications

A short review on emotion processing: a lateralized network of neuronal networks

A short review on emotion processing: a lateralized network of neuronal networks

Cortical visual area CSv as a cingulate motor area: a sensorimotor interface for the control of locomotion

Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle Cognitive Decline

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