Cinchona Alkaloids in the Synthesis of Chiral Salts of Phosphorus Dithioacids on the Basis of 1,2:3,4‐Di‐O‐isopropylidene‐α‐D‐galactopyranose

Abstract

Optically active dithiophosphoric and dithiophosphonic acids were obtained by the reactions of 1,2:3,4‐di‐O‐isopropylidene‐α‐D‐galactopyranose with tetraphosphorus decasulfide or Lawesson's reagent respectively. The reactions of dithiophosphoric and dithiophosphonic acids with 8 S,9R‐quinine, 8R,9 S‐quinidine, 8 S,9R‐cinchonidine, 8R,9 S‐cinchonine, and 8R,9 S‐hydroquinidine result in chiral salts of dithiophosphoric and dithiophosphonic acids. Antimicrobial activity of products obtained was tested.

Nematicidal activity of menthol and its dithiophosphoric derivatives

“…Our research group curries out systematic research on the creation of biologically active drugs based on dithiophosphoric acids and their salts using nitrogenous organic compounds [21][22][23][24], many of these acids were obtained from monoterpene alcohols. We assumed that dithiophosphoric acids obtained from enantiomerically pure menthols and their salts can be of interest for studying nematicidal activity.…”