Cilostazol promotes survival of axotomized retinal ganglion cells in adult rats

Axonal regeneration induced by repetitive electrical stimulation of crushed optic nerve in adult rats

“…RGCs were retrogradely labeled by placing a small sponge that had been soaked in 2% FluoroGold (FG; Fluorochrome, Englewood, NJ, USA) on both superior colliculi after craniotomy. [15][16][17] Seven days after FG application, the left ON was crushed with jewelry forceps. Twelve days later, each operated rat was perfused transcardially with saline followed by 4% PFA in 0.1 M PB.…”

Cilostazol Attenuates Spinal Cord Ischemia-Reperfusion Injury in Rabbits

“…Also, it has been reported that cilostazol might have a neuroprotective effect in retinal injury after transient ischemia and optic nerve injury. 15,42 Unfortunately, the studies on cilostazol against prevention of I/R injury have insufficient reported results in the spinal cord. Only one study by Sahin et al 18 found that administration of cilostazol reduced the I/Rinduced neurologic injury and produced clinical improvement by attenuating oxidative stress in rats when treated orally (20 mg/ kg) 3 days before spinal cord ischemia (aortic clamping time: 45 minutes).…”

Neuroprotective Effects of Cilostazol on Retinal Ganglion Cell Damage in Diabetic Rats

“…Recent studies have demonstrated that cilostazol can reduce the degree of neuronal cell death after transient cerebral ischemia (Lee et al, 2006). With regard to the retina, a neuroprotective effect of cilostazol has been reported in an animal model of ischemia-reperfusion injury or optic nerve axotomy (Iwama et al, 2007;Kashimoto et al, 2008). However, there have been no studies concerning the effect of cilostazol on diabetic retina.…”