Axonal regeneration induced by repetitive electrical stimulation of crushed optic nerve in adult rats

Tagami, Yuichi; Kurimoto, Takuji; Miyoshi, Tomomitsu; Morimoto, Takeshi; Sawai, Hirozumi; Mimura, Osamu

doi:10.1007/s10384-009-0657-8

Cited by 68 publications

(59 citation statements)

References 31 publications

(34 reference statements)

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“…Enhanced survival of RGCs has also been observed after optic nerve crush, 15,16,20,32 after light-induced retinal damage, 26 and in ischemic rat retinas. 33 Tagami et al 32 revealed that the increased survival of RGCs was in accordance with the number of TES applications and that the daily application of TES exhibited the most effect.…”

Section: Tes In Animal Modelsmentioning

confidence: 87%

“…33 Tagami et al 32 revealed that the increased survival of RGCs was in accordance with the number of TES applications and that the daily application of TES exhibited the most effect. Furthermore, daily TES administration resulted in the up-regulated expression of IGF-1 to a greater extent than a single application of TES.…”

Section: Tes In Animal Modelsmentioning

confidence: 94%

“…However, beneficial effects of ES have been shown in one study using transorbital ES 14 and in several animal experiments using TES (Table 1). 15e35 These studies can be categorized as follows: i) healthy animals 17e19, 23,26,31,34 ; ii) transgenic animals 22,28 ; iii) animals as a disease model for RP 21 ; iv) animals with induced ischemic insult, 27,29,33 optic nerve crush, 15,16,20,32 and transected optic nerve 24,25 ; and v) animal cells isolated from the retina. 35 …”

Section: Animal Experimentsmentioning

confidence: 99%

“…Finally, enhanced regeneration of RGC axons by daily application of TES was completely blocked by a specific antagonist to the IGF-1 receptor, whereas the promotion of surviving RGCs was not. 32 In a study involving Royal College of Surgeons rats, a generally used model for inherited retinal degeneration such as RP, the researchers demonstrated that retinal degenerative processes are markedly slowed by TES. TES increased survival of photoreceptors, as suggested by a significantly greater thickness of the outer nuclear layer, preserved ERG b-wave, and impaired retinal function in Royal College of Surgeons rats.…”

Section: Tes In Animal Modelsmentioning

confidence: 99%

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Electrical Stimulation as a Means for Improving Vision

Sehic

Guo

Cho

et al. 2016

The American Journal of Pathology

138

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Evolving research has provided evidence that noninvasive electrical stimulation (ES) of the eye may be a promising therapy for either preserving or restoring vision in several retinal and optic nerve diseases. In this review, we focus on minimally invasive strategies for the delivery of ES and accordingly summarize the current literature on transcorneal, transorbital, and transpalpebral ES in both animal experiments and clinical studies. Various mechanisms are believed to underlie the effects of ES, including increased production of neurotrophic agents, improved chorioretinal blood circulation, and inhibition of proinflammatory cytokines. Different animal models have demonstrated favorable effects of ES on both the retina and the optic nerve. Promising effects of ES have also been demonstrated in clinical studies; however, all current studies have a lack of randomization and/or a control group (sham). There is thus a pressing need for a deeper understanding of the underlying mechanisms that govern clinical success and optimization of stimulation parameters in animal studies. In addition, such research should be followed by large, prospective, clinical studies to explore the full potential of ES. Through this review, we aim to provide insight to guide future research on ES as a potential therapy for improving vision. (Am J Pathol 2016 http://dx

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Section: Tes In Animal Modelsmentioning

confidence: 87%

Section: Tes In Animal Modelsmentioning

confidence: 94%

Section: Animal Experimentsmentioning

confidence: 99%

Section: Tes In Animal Modelsmentioning

confidence: 99%

See 2 more Smart Citations

Electrical Stimulation as a Means for Improving Vision

Sehic

Guo

Cho

et al. 2016

The American Journal of Pathology

138

View full text Add to dashboard Cite

show abstract

“…They have also collected evidence for enhanced survival of ganglion cells after optic nerve injury [9][10][11][12][13] (crush or axotomy), for increased survival of different retinal cell populations after light-induced retinal damage [14,15], and for increased cell survival in ischemic rat retinas [16]. Likely mechanisms, elucidated in these experiments, include advantageous regulation of neurotrophins such as endogenous insulin-like growth factor (IGF)-1 [10,14,17] and Fgf2 [18], involvement of B-cell lymphoma 2 (Bcl-2)…”

Section: Animal Experimentsmentioning

confidence: 99%

Electrical stimulation — a therapeutic strategy for retinal and optic nerve disease?

Gekeler¹,

Bartz‐Schmidt²

2012

Graefes Arch Clin Exp Ophthalmol

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Application of electrostimulation and magnetic stimulation in patients with optic neuropathy: A mechanistic review

Khalili,

Shadmani,

Sanie‐Jahromi

2024

Developmental Neurobiology

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Visual impairment caused by optic neuropathies is irreversible because retinal ganglion cells (RGCs), the specialized neurons of the retina, do not have the capacity for self‐renewal and self‐repair. Blindness caused by optic nerve neuropathies causes extensive physical, financial, and social consequences in human societies. Recent studies on different animal models and humans have established effective strategies to prevent further RGC degeneration and replace the cells that have deteriorated. In this review, we discuss the application of electrical stimulation (ES) and magnetic field stimulation (MFS) in optic neuropathies, their mechanisms of action, their advantages, and limitations. ES and MFS can be applied effectively in the field of neuroregeneration.. Although stem cells are becoming a promising approach for regenerating RGCs, the inhibitory environment of the CNS and the long visual pathway from the optic nerve to the superior colliculus are critical barriers to overcome. Scientific evidence has shown that adjuvant treatments, such as the application of ES and MFS help direct thetransplanted RGCs to extend their axons and form new synapses in the central nervous system (CNS). In addition, these techniques improve CNS neuroplasticity and decrease the inhibitory effects of the CNS. Possible mechanisms mediating the effects of electrical current on biological tissues include the release of anti‐inflammatory cytokines, improvement of microcirculation, stimulation of cell metabolism, and modification of stem cell function. ES and MFS have the potential to promote angiogenesis, direct axon growth toward the intended target, and enhance appropriate synaptogenesis in optic nerve regeneration.

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Axonal regeneration induced by repetitive electrical stimulation of crushed optic nerve in adult rats

Abstract: TES applied daily promotes both axonal regeneration and survival of RGCs after ON crush.

Cited by 68 publications

References 31 publications

Electrical Stimulation as a Means for Improving Vision

Electrical Stimulation as a Means for Improving Vision

Electrical stimulation — a therapeutic strategy for retinal and optic nerve disease?

Application of electrostimulation and magnetic stimulation in patients with optic neuropathy: A mechanistic review

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