Cilostazol and pentoxifylline decrease angiogenesis, inflammation, and fibrosis in sponge-induced intraperitoneal adhesion in mice

Mendes, Juliana B.; Campos, Paula Peixoto; Rocha, Monaliza Angela; Andrade, Sílvia Passos

doi:10.1016/j.lfs.2009.01.023

Cited by 37 publications

(52 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…129 Given that postoperative oxidative stress is linked to neutrophil recruitment 49 and decreased fibrinolytic activity, 50 and subsequently the development of intraabdominal adhesions, antioxidants, through the reduction in levels of oxidative stress and increasing PAA and MMP activities postoperatively, may contribute to reduction in adhesion development. 130 Consistent with this hypothesis, in the rat model experiments, antioxidants such as methylene blue, 50,131 indigo carmine, 132 pentoxifylline, 133 and neurokinin 1 receptor CJ-12-255 (Pfizer) antagonist 49 have been shown to inhibit postoperative adhesion development. Modulation of the immune response to peritoneal injury may modify postoperative adhesion formation.…”

Section: Possible Role Of Enzymes Polypeptides and Antioxidants In mentioning

confidence: 67%

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

et al. 2014

View full text Add to dashboard Cite

Over the past several years, there has been increasing recognition that pathogenesis of adhesion development includes significant contributions of hypoxia induced at the site of surgery, the resulting oxidative stress, and the subsequent free radical production. Mitochondrial dysfunction generated by surgically induced tissue hypoxia and inflammation can lead to the production of reactive oxygen and nitrogen species as well as antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase which when optimal have the potential to abrogate mitochondrial dysfunction and oxidative stress, preventing the cascade of events leading to the development of adhesions in injured peritoneum. There is a significant cross talk between the several processes leading to whether or not adhesions would eventually develop. Several of these processes present avenues for the development of measures that can help in abrogating adhesion formation or reformation after intraabdominal surgery.

show abstract

Section: Possible Role Of Enzymes Polypeptides and Antioxidants In mentioning

confidence: 67%

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The number of neutrophils in implants was measured by assaying myeloperoxidase (MPO) activity as previously described (Ferreira et al2004;Mendes et al 2009a). The implants for this set of experiments were removed 9 days post-implantation after daily doses of the compounds.…”

Section: Tissue Extraction and Determination Of Myeloperoxidase And Nmentioning

confidence: 99%

“…The infiltration of mononuclear cells into the implants was quantified by measuring the levels of the lysosomal enzyme N-acetylglucosaminidase (NAG) present in high levels in activated macrophages (Ferreira et al 2004;Mendes et al 2009a). The implants removed 9 days post-implantation were homogenized in NaCl solution (0.9% w/v) containing 0.1% v/v Triton X-100 (Promega) and centrifuged (3,0009g; 10 min at 4°C).…”

Section: Tissue Extraction and Determination Of Myeloperoxidase And Nmentioning

confidence: 99%

“…Inflammation, angiogenesis and remodeling are selflimiting processes under normal healing conditions (Mendes et al 2009a). Angiogenesis is a fundamental process to normal and abnormal tissue growth and repair, which consists of recruiting endothelial cells toward an angiogenic stimulus.…”

Section: Introductionmentioning

confidence: 99%

“…Angiogenesis is a fundamental process to normal and abnormal tissue growth and repair, which consists of recruiting endothelial cells toward an angiogenic stimulus. However, if one or more of those processes are maintained further injury is caused resulting in chronic inflammatory conditions (Gong and Koh 2010;Mendes et al 2009a;Walsh and Pearson 2001). Chronic inflammatory processes such as rheumatoid arthritis, Crohn's disease and psoriasis share these abnormal healing features.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Coordination of lapachol to bismuth(III) improves its anti-inflammatory and anti-angiogenic activities

et al. 2011

View full text Add to dashboard Cite

Complex [Bi(Lp)(2)]Cl was obtained with 4-hydroxy-3-(3-methylbut-2-enyl)naphthalene-1,2-dione, "lapachol" (HLp). Lapachol, [Bi(Lp)(2)]Cl and BiCl(3) were evaluated in a murine model of inflammatory angiogenesis induced by subcutaneous implantation of polyether polyurethane sponge discs. Intraperitoneal (i.p.) administration of lapachol or [Bi(Lp)(2)]Cl reduced the hemoglobin content in the implants suggesting that reduction of neo-vascularization was caused by lapachol. In the per os treatment only [Bi(Lp)(2)]Cl decreased the hemoglobin content in the implants. Likewise, N-acetylglucosaminidase (NAG) activity decreased in the implants of the groups i.p. treated with lapachol and [Bi(Lp)(2)]Cl while in the per os treatment inhibition was observed only for [Bi(Lp)(2)]Cl. Histological analysis showed that the components of the fibro-vascular tissue (vascularization and inflammatory cell population) were decreased in lapachol- and complex-treated groups. Our results suggest that both lapachol and [Bi(Lp)(2)]Cl exhibit anti-angiogenic and anti-inflammatory activities which have been attributed to the presence of the lapachol ligand. However, coordination to bismuth(III) could be an interesting strategy for improvement of lapachol's therapeutic properties.

show abstract

Amitriptyline efficacy in decreasing implant‐induced foreign body reaction

et al. 2023

Self Cite

View full text Add to dashboard Cite

Beyond its actions on the nervous system, amitriptyline (AM) has been shown to lower inflammatory, angiogenic, and fibrogenic markers in a few pathological conditions in human and in experimental animal models. However, its effects on foreign body reaction (FBR), a complex adverse healing process, after biomedical material implantation are not known. We have evaluated the effects of AM on the angiogenic and fibrogenic components on a model of implant‐induced FBR. Sponge disks were implanted subcutaneously in C57BL/6 mice, that were treated daily with oral administration of AM (5 mg/kg) for seven consecutive days in two protocols: treatment was started on the day of surgery and the implants were removed on the seventh day after implantation and treatment started 7 days after implantation and the implants removed 14 after implantation. None of the angiogenic (vessels, Vascular endothelial growth factor (VEGF), and interleukin‐1β (IL‐1β) or fibrogenic parameters (collagen, TGF‐β, and fibrous capsule) and giant cell numbers analyzed were attenuated by AM in 7‐day‐old implants. However, AM was able to downregulate angiogenesis and FBR in 14‐day‐old implants. The effects of AM described here expands its range of actions as a potential agent capable of attenuating fibroproliferative processes that may impair functionality of implantable devices.

show abstract

Cilostazol and pentoxifylline decrease angiogenesis, inflammation, and fibrosis in sponge-induced intraperitoneal adhesion in mice

Cited by 37 publications

References 33 publications

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

Coordination of lapachol to bismuth(III) improves its anti-inflammatory and anti-angiogenic activities

Amitriptyline efficacy in decreasing implant‐induced foreign body reaction

Contact Info

Product

Resources

About