Cigarette Smoking and the Risk of Mucinous and Nonmucinous Epithelial Ovarian Cancer

Modugno, Francesmary; Ness, Roberta B.; Cottreau, Carrie

doi:10.1097/00001648-200207000-00016

Cited by 65 publications

(49 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although many studies in the literature claimed that cigarette smoking was associated with an increased risk for ovarian cancers, especially mucinous epithelial ovarian cancer. [16][17][18] Goodman and Tung reported that active tobacco smoking was not a risk factor for invasive ovarian cancer. 19 In a recent large population study, epithelial ovarian cancer did not observe an association with smoking.…”

Section: Discussionmentioning

confidence: 99%

Study of risk factors and tumor markers in ovarian malignancy in western part of Odisha: a prospective observational study

Pradhan¹,

Singh²,

Ravikumar³

et al. 2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Ovarian cancer represents one of the most frequently seen malignancies in women and it is the fifth most common cause of cancer-related death in women. The aim of the study to determine the risk factors leading to ovarian cancer in western part of Odisha, India and show the tumour markers in this population.Methods: This is a prospective observational study included 240 ovarian masses diagnosed at Department of Obstetrics and Gynaecology, V. S. S. Medical College, Burla, Sambalpur over 3 years based on preoperative clinical, biochemical (tumour markers) and imaging study and confirm through post-operative histopathology reports.Results: Surface epithelial tumours (68.33%) followed by germ cell tumours (30.83%) are the most common ovarian tumour. Incidence of ovarian cancer is 73.58% in ≤50 years of age group and more number of cases (16.65%) also found in younger age (≤30 year). Overall number of ovarian cancer cases rising. Bilateral tubal ligation is not a protective factor for ovarian cancer (p value >0.05) and consumption of alcohol and tobacco is not increase risk for ovarian cancer. Most of ovarian tumour commonly present with vague abdominal pain (75.83%) followed by mass per abdomen (55%). Ascites mainly a presentation of malignant tumour seen in 46(63.88%) cases. CA125 is the frequently detected tumour markers and all of the tumour markers were significantly within normal limit.Conclusions: Ovarian neoplasia is one of the most common and lethal malignancy in female reproductive tract. Though it is a disease of older age but now a day more no of cases also seen in younger age group. Since most of the ovarian cancer remain asymptomatic for long period so measure should be taken for early diagnosis for best outcome. So, assessment of each regions statistical information reflecting its own profile may be important for estimation of risk for development of ovarian cancer and so useful for early preventive measure before progress to advance stage where prognosis is worst. So, relationship between the profiles of patients and types of ovarian neoplasms may give an idea about the risk factors of the disease in its region. Additionally, distribution of tumour markers might be considered for the dis-criminating of the benign or malign characters of the ovarian neoplasia.

show abstract

Section: Discussionmentioning

confidence: 99%

Study of risk factors and tumor markers in ovarian malignancy in western part of Odisha: a prospective observational study

Pradhan¹,

Singh²,

Ravikumar³

et al. 2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Some studies [7][8][9]11,12,15 in the review 6 also suggest that smoking may have a promoting effect regarding the development of mucinous tumors because of the short period of smoking exposure before diagnosis. Furthermore, Jordan et al, discuss the possibility that the revealed increased risk may be due to misclassification of mucinous tumors from the gastrointestinal tract, pancreas or cervix that present clinically as primary ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Jordan et al found that there was a significant doubling in risk of mucinous, but not of serous, endometroid and clear cell ovarian cancers among current smokers compared to never smokers. 6 This meta-analyses included data from 1 cohort study, 7 8 population based case-control studies [8][9][10][11][12][13][14][15] and 1 pooled analysis of 10 case-control studies from the US. 16 Because the use of tobacco is rising sharply globally, 17 smoking may generate large numbers of ovarian cancers if a causal association exists.…”

mentioning

confidence: 99%

Cigarette smoking and risk of borderline and invasive epithelial ovarian cancer

Gram

Br̈aaten

Adami

et al. 2007

Intl Journal of Cancer

View full text Add to dashboard Cite

Studies regarding the association between smoking and risk of epithelial ovarian cancer (EOC) are inconsistent. The purpose of this study was to examine the association between smoking and EOC, overall and according to invasiveness and histological subtype in a cohort of women with a high proportion of smokers at enrolment. We followed 103,081 women, aged 30-50 years in 1991/1992, from the Norwegian-Swedish Women's Lifestyle and Health cohort. The women completed a questionnaire on personal characteristics and exposures at enrolment and were subsequently followed with linkages to national registers through December 31, 2004. We used Cox proportional hazard regression models to estimate hazard ratio (RR) of EOC with 95% confidence intervals (CIs) associated with different measures of smoking exposures adjusting for confounding variables.

show abstract

“…Whether the risk of other subtypes of ovarian cancer might also be influenced by cigarette smoking is less certain, as prior studies have not been uniform in their findings (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

Cigarette smoking and risk of epithelial ovarian cancer

Rossing

Cushing‐Haugen

Wicklund

et al. 2007

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

Cigarette Smoking and the Risk of Mucinous and Nonmucinous Epithelial Ovarian Cancer

Abstract: Cigarette smoking appears to be a risk factor for mucinous but not for nonmucinous tumors.

Cited by 65 publications

References 28 publications

Study of risk factors and tumor markers in ovarian malignancy in western part of Odisha: a prospective observational study

Study of risk factors and tumor markers in ovarian malignancy in western part of Odisha: a prospective observational study

Cigarette smoking and risk of borderline and invasive epithelial ovarian cancer

Cigarette smoking and risk of epithelial ovarian cancer

Contact Info

Product

Resources

About