Cigarette smoking and testosterone in men and women: A systematic review and meta-analysis of observational studies

Zhao, Jie; Leung, June Yue Yan; Lin, Shi Lin; Schooling, C. Mary

doi:10.1016/j.ypmed.2015.12.021

Cited by 73 publications

(58 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The increased concentration of LH with diminished circulatory testosterone levels in experimental mice may suggest an intact pituitary–testicular axis (Souza et al, 2016). The literature on the effect of cigarette smoking on testosterone is at variance, as shown in a recent review article (Zhao et al, 2016). Most of the published papers found that smokers had higher mean testosterone than non-smokers in men, and no clear effect on women.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the published papers found that smokers had higher mean testosterone than non-smokers in men, and no clear effect on women. This has been explained by hypothesizing that nicotine and/or its metabolites have a common disposal pathway with androgenic hormones, and so can competitively inhibit androgen disposal (Zhao et al, 2016). However, in our work, the urinary excretion of nicotine metabolite was significantly enhanced, and we also found slight but significant decreases in both testosterone and estradiol concentrations in plasma, and no significant effect on LH.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Water-Pipe Smoke Exposure Induces Injurious Effects to Reproductive System in Male Mice

et al. 2017

View full text Add to dashboard Cite

There is a global increase in the popularity of water-pipe tobacco smoking including in Europe and North America. Nevertheless, little is known about the male reproductive effects of water-pipe smoke (WPS), especially after long-term exposure. Here, we assessed effects of WPS exposure (30 min/day) in male mice for 6 months. Control mice were exposed to air-only for the same period of time. Twenty-four hours after the last exposure, testicular histopathology, and markers of inflammation and oxidative stress, and the tyrosine–protein kinase vascular endothelial growth factor receptor 1 (VEGFR1) were assessed in testicular homogenates. Moreover, plasma testosterone, estradiol, and luteinizing hormone (LH) concentrations were also measured. Chronic WPS exposure induced a significant decrease of testosterone and estradiol, and a slight but significant increase of LH. Glutathione reductase, catalase, and ascorbic acid were significantly decreased following WPS exposure. Plasma concentration of leptin was significantly decreased by WPS exposure, whereas that of tumor necrosis factor α and interleukin 6 was significantly increased. Histopathological analysis of the testes revealed the presence of a marked reduction in the diameter of the seminiferous tubules with reduced spermatogenesis. Transmission electron microscopy examination showed irregular thickening and wrinkling of the basement membranes with abnormal shapes and structures of the spermatozoa. VEGFR1 was overexpressed in the testis of the mice exposed to WPS and was not detected in the control. The urine concentration of cotinine, the predominant metabolite of nicotine, was significantly increased in the WPS-exposed group compared with the control group. We conclude that chronic exposure to WPS induces damaging effects to the reproductive system in male mice. If this can be confirmed in humans, it would be an additional concern to an already serious public health problem, especially with the increased use of WPS use all over the world, especially in young adults.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chronic Water-Pipe Smoke Exposure Induces Injurious Effects to Reproductive System in Male Mice

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Halmenschlager et al found no relation between smoking and testosterone level 19 but the results of a meta-analysis showed that in a group of healthy men aged 18-61 years, smokers had a higher mean testosterone than non-smokers. 20 Moreover, the Tromsø Study showed differences between testosterone concentration in current, ex-and never-smokers. 21 Our study did not confirm these results.…”

Section: Discussionmentioning

confidence: 99%

Serum testosterone depression as a factor influencing the general condition in chronic obstructive pulmonary disease patients

Rubinsztajn¹,

Przybyłowski²,

Maskey-Warzęchowska³

et al. 2019

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. Testosterone has been recognized for its anabolic properties. It has been documented that in patients with chronic obstructive pulmonary disease (COPD), chronic hypoxia, disease severity, smoking, and corticosteroid treatment may contribute to low testosterone levels.Objectives. The aim of the study was to evaluate the incidence of decreased serum testosterone concentration in male COPD patients and its influence on their condition.Material and methods. The study group consisted of 90 male patients, aged 67.2 ±8.8 years in all stages of airflow limitation severity (mild n = 6, moderate n = 43, severe n = 28 and very severe n = 13) Serum testosterone concentration was evaluated using ELISA method (Testosterone ELISE LDN). Decreased serum testosterone level was defined as a value of less than 3 ng/mL. Testosterone levels were related clinical features of COPD.Results. Serum testosterone concentration did not differ in patients with different stages of airflow limitation severity (3.8 ±0.7 ng/mL for mild: 3.6 ±2. 1 ng/mL for moderate; 3.4 ±1.2 ng/mL for severe and 3.7 ±1.7 ng/mL for very severe, respectively). Decreased serum testosterone was found in 30 patients (group A). There were no differences in age, the number of exacerbations or CRP concentration between patients with decreased and the normal serum testosterone group (group B). Group A was characterized by a lower FEV1, shorter 6-minute walking distance, longer smoking history and higher BMI, but no differences in body composition and densitometry results were found.Conclusions. Serum testosterone depression may occur in as much as 30% of male COPD patients in all COPD stages of severity. The relationship between serum testosterone and negative COPD prognostic factors indicates its influence on the natural history of the disease.

show abstract

“…Kadın ve erkeklerde nikotinin etkisi ile birçok hormon düzeyinin nikotinden farklı etkilenebildiği gösterilmiştir. [24] Çalışmamızdaki bu sonucun sigara içen kadın ve erkeklerde nikotinin etkisi ile değişen hormon seviyeleri sonucunda olabileceğini düşünmekteyiz. Ayrıca AYDINHİP çalışmasına göre çalışmamızda yöremizdeki erkeklerin sigara içme oranlarının yaklaşık %31 azaldığı gösterilmiştir.…”

Section: Discussionunclassified

The evolution of smoking and hypertension association in last 20 years in the city of Aydın

Uysal¹,

Yaşar²,

Sönmez³

2016

tahd

View full text Add to dashboard Cite

Yöntem: Çalışmamız kesitsel bir araştırma niteliğindedir. Veriler, önceden hazırlanmış olan anket formları kullanılarak, rastgele örneklem yöntemi ile seçilmiş 18 yaş üzerindeki kişilere ev veya işyerlerinde yüz yüze görüşme tekniği ve kan basıncı ölçümü ile elde edildi. Çalışmamızda çift tabakalı küme örneklem yöntemi kullanıldı.Bulgular: Çalışmaya 2528 katılımcı dâhil edildi. Katılımcıların %59'u kadın, %41'i erkekti. Tüm katılımcıların %26,7'si sigara içmekte idi. Erkekler istatistiksel olarak anlamlı şekilde kadınlardan daha fazla sigara içmekte idi (p<0,001). Lise ve altında eğitim durumuna sahip katılımcılarda sigara içme oranları %23,4 iken, üstünde eğitime sahip kişilerde sigara içme oranları %33,2 olarak saptandı (p<0,001). Çalışmaya katılan erkekler, kadınlara göre (p<0,001), hipertansif katılımcılar hipertansif olmayanlara göre daha uzun süredir sigara içi-yordu (p<0,001). Toplam nüfusumuzun %30,9'u hipertansif olarak saptandı. Kadınlarda bu oran %31,0 iken erkeklerde %30,8 idi.Sigara içenler ve içmeyenler arasında hipertansiyon sıklığı açısından anlamlı fark saptandı (p<0,001). Buna göre hipertansif bireylerin %20,3'ü sigara içerken, hipertansiyonu olmayan katılımcıların %29,7'si sigara içiyordu. Sigara içenlerin SKB ve DKB ortanca değerleri, içmeyen-lerinkinden daha düşük olmasına karşın istatistiksel olarak anlamlı fark saptanmadı (p>0,05). Sigara içenlerde içilen sigara sayısı ile orantılı olarak SKB ve DKB değerlerinde yükselme gözlendi (p<0,001).Sonuç: Çalışmamızda son 20 yıl içinde, özellikle erkek katılımcılarda belirgin olmak üzere, yöremizde sigara içme oranlarında %36'lık bir düşüş olduğu gözlenmiştir. HT prevalansında, azalan sigara içimi oranlarına benzer bir düşüş gözlenmemiştir. AYDINHİP çalışması ve mevcut çalışmamızın her ikisinde de sigara içmeyenlerde hipertansiyon prevalansı, içenlere oranla daha yüksek bulunmuştur.Anahtar sözcükler: Hipertansiyon, prevalans, sigara SummaryObjective: Smoking and hypertension (HT) are both preventable cardiovascular risk factors. But the relationship between hypertension and smoking is not clear yet. In our study we aimed to reveal the HT epidemiology in both smoking and non-smoking people around the city of Aydin. We will evaluate the impact of the smoking changes on HT prevalence by comparing our results with AYDIN-HIP study which was conducted around Aydin, 20 years ago. Methods:Our study is designed as a cross-sectional study. People older than 18 years were selected with a random sampling method. A previously prepared questionnaire was applied by face to face method before blood pressure measurements. Stratified sampling method was used in our study.Results: 2528 persons enrolled in our study. The 59% of participants were female and 41% were male. 26,7% of participants were smoking. Men were significantly smoking much more than women (p<0.001). Smoking rate of the high school or lower educated participants was 23,4% while it was 33.2% in high school or higher educated participants (p<0.001). Men and hypertensive participants were smoking for a ...

show abstract

Cigarette smoking and testosterone in men and women: A systematic review and meta-analysis of observational studies

Cited by 73 publications

References 74 publications

Chronic Water-Pipe Smoke Exposure Induces Injurious Effects to Reproductive System in Male Mice

Chronic Water-Pipe Smoke Exposure Induces Injurious Effects to Reproductive System in Male Mice

Serum testosterone depression as a factor influencing the general condition in chronic obstructive pulmonary disease patients

The evolution of smoking and hypertension association in last 20 years in the city of Aydın

Contact Info

Product

Resources

About