Cigarette Smoking and Survival after Ovarian Cancer Diagnosis

Nagle, Christina M.; Bain, Christopher; Webb, Penelope M.

doi:10.1158/1055-9965.epi-06-0592

Cited by 30 publications

(28 citation statements)

References 22 publications

(23 reference statements)

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“…However, there was no distinction made between tumors of differing grades or histologies. Other studies have suggested that current cigarette use at the time of ovarian cancer diagnosis increases the risk of death by as much as 65% 10, 11 . While these investigations do adjust for such variables as tumor histology, stage, chemotherapy, and grade, the grading systems do not follow the two-tier system or FIGO grading criteria, thus making these conclusions difficult to interpret.…”

Section: Discussionmentioning

confidence: 99%

Clinicodemographic factors influencing outcomes in patients with low-grade serous ovarian carcinoma

Schlumbrecht

Sun

Wong

et al. 2011

Cancer

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Background Low-grade serous carcinoma (LGSC) of the ovary is a rare tumor that is distinct from its high-grade counterpart. Our aim was to estimate if patient demographic factors and clinical treatment histories affected survival in a population of women with this disease. Methods A review of patients with pathologically-confirmed LGSC of the ovary diagnosed between 1977- 2009 was performed. Abstracted data included medical and social histories, anthropometric measurements, and details about diagnosis, treatment, and follow-up. Statistical analyses included Fisher's exact test, Cox proportional hazards models, and the Kaplan-Meier method. Results The study sample included 194 patients with a median follow-up of 60.9 months (range 1-383). By multivariable analyses, smoking was negatively associated with both overall survival (OS) (HR 1.73; 95% CI [1.03-2.92], p=0.04) and progression-free survival (PFS) (HR 1.72; 95% CI [1.00-2.96], p=0.05). Median OS was shorter in current smokers than former/never smokers (48.0 vs. 79.9 months; p=.002). PFS was also predicted by year of diagnosis >1994 (HR1.74, p=0.01). Although not statistically significant, hormone consolidation appeared to be associated with better OS (HR 0.15, p=.06) and better PFS (HR 0.44; p=.07). A smaller proportion of patients treated with hormone consolidation experienced recurrence compared to those who did not receive hormone consolidation (66.7% vs. 87.6%, p=0.07). Conclusion Smoking is negatively associated with survival outcomes in women with LGSC of the ovary, while consolidation treatment with hormone antagonists demonstrated a protective associative trend with survival. Both lifestyle modification and innovative treatment plans should be considered in this group of patients.

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Section: Discussionmentioning

confidence: 99%

Clinicodemographic factors influencing outcomes in patients with low-grade serous ovarian carcinoma

Schlumbrecht

Sun

Wong

et al. 2011

Cancer

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“…Smoking status was defined as non-smoker, ex-smoker and current smoker. A regular smoker was defined as one who smokes at least 1 cigarette per day for over 1 year and a current smoker as one who regularly smokes for at least 1 year and continues to smoke within 1 year prior to surgery, an ex-smoker was defined as one who quit smoking for more than 1 year before surgery [17], [24]. Postoperative smoker was defined as one who smokes within first year postoperatively for at least one year or till death.…”

Section: Methodsmentioning

confidence: 99%

Impact of Cigarette Smoking on Outcome of Hepatocellular Carcinoma after Surgery in Patients with Hepatitis B

et al. 2014

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Background and ObjectivesCigarette smoking is a potential risk factor for hepatocellular carcinoma (HCC) initiation, partially through interaction with hepatitis B virus (HBV). We examined the hypothesis that cigarette smoking might be associated with HBV-related HCC recurrence and patient survival after curative surgery.Patients and MethodsData of 302 patients with HBV infection who had undergone curative resection for HCC were prospectively collected from 2008 to 2011. Smoking status and smoking quantity (pack-years, PY) were asked at admission. Factors affecting recurrence-free survival (RFS) were examined. RFS and liver-specific mortality (LSM) stratified by risk factors were compared with log-rank test.Results109 were current smokers. Current smokers were not different from non-smokers in tumor burden and surgical procedure. Univariate and multivariate analysis identified that heavy smoking (PY ≥20) was the most significant factor associated with HBV-related HCC recurrence after curative surgical resection (p = 0.001), followed by anti-HBV treatment (p<0.01), current smoking (p = 0.028), surgical margin <1 cm (p = 0.048) and blood transfusion >600 ml (p = 0.028). The median RFS in non-smokers, ex-smokers and current smokers was 34 months, 24 months and 26 months, respectively (p = 0.033). Current smokers had significantly worse RFS rate and increased 5-year cumulative LSM than non-smokers (p = 0.024, and p<0.001, respectively). Heavy smokers had significantly worse RFS than non- and light smokers (0

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“…In the MALOVA study (n = 295 cases, 245 deaths) and an Australian study (676 cases, 419 deaths), women who reported smoking at the time of or within one year of diagnosis were at higher risk of dying (HR = 1.65, 95% CI = 1.22-2.24 and HR = 1.36, 05% CI = 1.01-1.84, respectively) [62,63]. However, in a Swedish study (635 cases, 396 deaths), there was no association with current smoking (HR = 0.94, 95% CI = 0.70-1.26) [34].…”

Section: Smokingmentioning

confidence: 99%