Cigarette smoking and <i>glutathione S‐transferase M1</i> polymorphism associated with risk for uterine cervical cancer

Nishino, Kazumi; Sekiguchi, Masayuki; Kudoh, Shoji; Sudo, Natsuru; Aoki, Yoichi; Seki, Nao; Tanaka, Kenichi

doi:10.1111/j.1447-0756.2008.00798.x

Cited by 32 publications

(18 citation statements)

References 32 publications

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“…[27][28][29] An association between the glutation S-transferase mu 1 null genotype and cervical cancer was reported in an US population 30 and a Japanese population. 31 Both the risk of HPV infection and the risk to develop cervical cancer are associated with lifestyle factors; for example, the use of oral contraceptives, smoking, education, physical activity, high parity, risky sexual behavior, multiple sexual partners and previous exposure to other sexually transmitted diseases. 30,32,33 Several of these factors are considered to be environmental, but it should be noted that lifestyle factors, such as smoking, physical activity and risky sexual behavior, are influenced both by genetic and environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Cervix smear abnormalities: linking pathology data in female twins, their mothers and sisters

et al. 2010

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Mass screening for cervical cancer precursors has decreased the incidence of cervical cancer in several countries, including the Netherlands. Persistent infections of certain types of human papillomavirus are strongly associated with the development of cervical cancer. A number of factors may affect the liability to infection and subsequent progression to cervical intraepithelial neoplasia and cancer. This paper examines whether genetic factors are involved in explaining individual differences in liability. Data of 3178 women registered with the Netherlands Twin Register were successfully linked to the nationwide Dutch Pathology database that contains all results of mass screening for cervical cancer. The data from mono-and dizygotic twins and their female relatives were used to disentangle the influence of heritable and environmental factors on cervix smear abnormalities. Results showed that differences in cervix smear results clustered within families and resemblance was stronger in monozygotic twins (correlation 0.37, 95% confidence interval: 0.12-0.58) compared with other first-degree relatives (correlation 0.14, 95% confidence interval: À0.01-0.29). The familial clustering for an abnormal cervix smear is due to shared genetic factors that explain 37% of the variance in liability. The largest proportion of the variation in cervical smear abnormalities is due to unique environmental factors.

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Section: Discussionmentioning

confidence: 99%

Cervix smear abnormalities: linking pathology data in female twins, their mothers and sisters

et al. 2010

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“…With our search criterion, 123 individual records were found, but only 31 full-text articles were preliminarily identified for further detailed evaluation. According to the exclusion criteria, 15 articles were excluded including 5 articles containing overlapping population [7][8][9][10][11], 8 precancerous lesions included in the cases [12][13][14][15][16][17][18][19], 2 without sufficient data [20][21]. At last, data were available from 16 individual case-control studies [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], Table 1 presented characteristics of these 16 case-control studies (a total of 1,627 CC cases and 2,161 controls).…”

Section: Resultsmentioning

confidence: 99%

“…Compared with Economopoulos et al 's meta-analysis, our meta-analysis had some differences. Firstly, our meta-analysis included three new eligible studies published in Chinese [22][23][24] and two new case-control studies [25][26] in English in 2010, and excluded four studies [13,16,18,19] that had precancerous lesions patients in cases. Secondly, Asians (including Chinese, Indians, Koreans, Japanese and Thais), Caucasians and Latinos were stratified by ethnicity in our meta-analysis, while Chinese (including Koreans, Japanese and Thais) and non-Chinese were stratified GSTM1 AND GSTT1 POLYMORPHISMS AND CERVICAL CANCER RISK Fig.…”

Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Wang

Wang²,

Jx³

et al. 2011

neo

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There were some studies on the associations between Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) polymorphisms and cervical cancer (CC) risk, but the results were inconsistent. Thus, a meta-analysis was performed.The electronic databases PubMed, Science Direct, CBM, and CNKI were searched for possible studies. Finally, 16 studies (1,627 cases and 2,161 controls) were included. For the GSTM1 and GSTT1 polymorphisms, the unadjusted odds ratios (OR) and 95% confidence intervals (95% CI) from each study were used to estimate summary OR. Subgroup analyses by ethnicity and histological type of CC were also performed.For the GSTM1 polymorphism, the null genotype of GSTM1 was associated with an increased CC risk in total population (OR=1.32, 95% CI=1.06-1.66). Similar association was found in Asians (OR=1.47, 95% CI=1.11-1.94), but not in Caucasians (OR=0.96, 95% CI=0.73-1.27). For the GSTT1 polymorphism, the null genotype of GSTT1 was not statistically significantly associated with CC risk in total population (OR=1.36, 95% CI=0.97-1.90). This result was also found in Asians (OR=1.27, 95% CI=0.87-1.85) and Caucasians (OR=1.09, 95% CI= 0.66-1.79), but not in Latinos (OR=4.58, 95% CI= 2.04-10.28). For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk in total population (OR=1.77, 95% CI= 1.14-2.75), and all the six studies were from Asia. For subgroup analyses by histological type of CC, the three aspects of the analyses above were all not significantly associated with CC risk in squamous cell carcinoma and adenocarcinoma, respectively.The null genotype of GSTM1 and the dual null genotypes of GSTM1/GSTT1 were risk factors in CC, and the null genotype of GSTT1 was not associated with CC risk.

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“…), genetic background independently plays an important role in this process . Over the past decade, several studies have focused on the relationship between CYP2E1 gene polymorphisms and cervical neoplasia (CN), including high-grade squamous intraepithelial lesion, cervical intraepithelial neoplasia, carcinoma in situ, and invasive cervical cancer (Kim et al, 2000;Ferreira et al, 2006;Sierra-Torres et al, 2003Nishino et al, 2008;Liu et al, 2009;von Keyserling et al, 2011). However, the results were not conclusive.…”

Section: Introductionmentioning

confidence: 99%

CYP2E1 PstI polymorphism increases cervical neoplasia risk: a meta-analysis

Wang¹,

He²

2015

Genet. Mol. Res.

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ABSTRACT. Cytochrome P4502E1 (CYP2E1) is a key enzyme in the metabolic activation of many carcinogens, but the roles of CYP2E1 polymorphisms in cervical neoplasia (CN) are inconclusive. Published case-control cohort studies from the Pubmed, Embase, and China National Knowledge Infrastructure databases were retrieved. Data were extracted and pooled odds ratios with 95% confidence intervals were calculated. Seven studies examining 1097 cases and 1117 controls were included in this meta-analysis. The pooled effect size showed no association between CYP2E1 RsaI and DraI polymorphisms and CN risk in a codominant model. However, using a recessive model, an association between the PstI polymorphism and CN risk was observed (odds ratio: 2.10, 95% confidence interval: 0.96-4.62, P = 0.06), indicating that individuals with the homozygous rare genotype have a higher risk of developing CN compared to those with homozygous wildtype and heterozygous genotypes. When stratified by ethnicity, the PstI polymorphism was significantly correlated with CN susceptibility in non-Asians (odds ratio: 3.74, 95% confidence interval: 1.13-12.43, P = 0.03). This meta-analysis suggests that the CYP2E1 PstI polymorphism increases the risk of CN in non-Asians.

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Cigarette smoking and glutathione S‐transferase M1 polymorphism associated with risk for uterine cervical cancer

Cited by 32 publications

References 32 publications

Cervix smear abnormalities: linking pathology data in female twins, their mothers and sisters

Cervix smear abnormalities: linking pathology data in female twins, their mothers and sisters

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

CYP2E1 PstI polymorphism increases cervical neoplasia risk: a meta-analysis

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