Ciclosporin A-induced sebaceous gland hyperplasia

Boschnakow, Anett; T, May; Assaf, C.; Tebbe, Beate; Zouboulis, Ch.C.

doi:10.1046/j.1365-2133.2003.05397.x

Cited by 46 publications

(25 citation statements)

References 7 publications

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“…[4] As with our patient, the development of sebaceous gland hyperplasia has been reported more frequently in male than female transplant recipients. [1,4,13,14] Sebaceous gland hyperplasia has not been observed in children who receive transplants. This is thought to be because of the immaturity of the pilosebaceous unit in childhood.…”

Section: Discussionmentioning

confidence: 94%

“…Some neoplastic transformations such as sebaceous gland hyperplasia, BCC, and lymphoma have been reported in transplant recipients receiving cyclosporine therapy. [1][2][3][4] Renal transplant recipients receiving long-term immunosuppresive therapy have been shown to have an increased risk of developing skin cancers, mainly SCC, compatible with a longer duration of immunosuppression. [5][6][7][8] The cumulative incidence for skin cancer has been reported as 48% [7] and 52% [8] after 10 years of graft survival.…”

Section: Discussionmentioning

confidence: 99%

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Coexistence of Basal Cell Carcinomas and Multiple Sebaceous Gland Hyperplasias in a Cyclosporine (Ciclosporin)-Treated Renal Transplant Recipient

Yaylı

Akyazı

Bahadır

et al. 2010

American Journal of Clinical Dermatology

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A 55-year-old man presented with multiple, asymptomatic, yellowish papules on his face with a 4-year history, and two non-healing tumoral lesions on his nose with a 7-month history. He was a renal transplant recipient and had been treated with cyclosporine (ciclosporin) for 9 years. A biopsy from the asymptomatic, yellowish papule on the face showed sebaceous gland hyperplasia, and biopsies from the lesions on the nose revealed basal cell carcinomas. The lesions on the nose were excised. Sebaceous gland hyperplasia and skin cancers are among the cutaneous neoplasms observed in renal transplant recipients receiving cyclosporine. To our knowledge, this is the third reported case of the coexistence of basal cell carcinomas and multiple sebaceous gland hyperplasias in a cyclosporine-treated renal transplant recipient.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Coexistence of Basal Cell Carcinomas and Multiple Sebaceous Gland Hyperplasias in a Cyclosporine (Ciclosporin)-Treated Renal Transplant Recipient

Yaylı

Akyazı

Bahadır

et al. 2010

American Journal of Clinical Dermatology

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“…27,[33][34][35] This may be the result of dysplastic epithelial proliferation from either immunosuppression or as a direct effect from cyclosporin. 27 A single case report associating SH with the start of highly active antiretroviral therapy for HIV has been published.…”

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confidence: 99%

Sebaceous lesions and their associated syndromes: Part I

Eisen¹,

Michael²

2009

Journal of the American Academy of Dermatology

126

114

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Sebaceous neoplasms have long been a source of confusion to dermatologists and pathologists alike. Disagreements regarding nomenclature, classification, and management have been longstanding. Sebaceous lesions represent a broad spectrum of interesting entities that range from hamartomas, hyperplasias, and benign tumors to highly malignant neoplasms. This article discusses the clinical and pathologic features of sebaceous hyperplasia, nevus sebaceous of Jadassohn, sebaceous adenoma, seboacanthoma, sebaceous epithelioma, sebaceoma, mantleoma, basal cell carcinoma with sebaceous differentiation, sebomatricoma (sebomatrixoma), and sebaceous carcinoma. Controversies regarding these lesions will be explored, and any relationship with Muir-Torre syndrome will be discussed.

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“…9,10 There is no direct association with malignant degeneration of SGH; however, it has been shown to be associated with Muir-Torre syndrome. 3 SGH treatment can be challenging due to the need to destroy and/or excise the entire sebaceous gland.…”

Section: Introductionmentioning

confidence: 96%

Light and laser therapies for the treatment of sebaceous gland hyperplasia a review of the literature

Simmons

Griffith

Falto‐Aizpurua

et al. 2015

Acad Dermatol Venereol

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Sebaceous gland hyperplasia (SGH) is a benign cutaneous condition that presents primarily on the face and increases with UVB exposure and ageing. These lesions are a common cosmetic concern but are difficult to treat, as the entire sebaceous gland needs to be destroyed to prevent recurrence. Traditional methods of treatment include: cryosurgery, electrodessication, curettage, shave excision and topical trichloroacetic acid. These methods have an increased risk of skin discoloration and scarring to the area of treatment that may lead to inferior cosmetic outcomes. Alternatively, oral isotretinoin can treat SGH, but is a known teratogen in pregnancy and has high relapse rates with discontinuation. A systematic review of the literature was performed to look at photodynamic therapy (PDT) and laser treatment for SGH. According to the results of this study, PDT, lasers and combinations of the two treatments were found to offer alternatives to the more conventional techniques with better outcomes. In particular, the use of wavelength-specific laser for the sebaceous gland of 1720 nm were found to have better outcomes and provide minimal damage to surrounding tissues. Additionally, combination PDT with aminolevulinic acid and pre-treatment with carbon dioxide laser ablation or pulse-dyed laser offered higher cure rates over stand-alone laser or PDT treatments in a shorter number of sessions with similar transient side-effects. However, further large-scale prospective studies with adequate follow-up are required to confirm these findings and those for sebaceous gland-specific lasers.

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Ciclosporin A-induced sebaceous gland hyperplasia

Cited by 46 publications

References 7 publications

Coexistence of Basal Cell Carcinomas and Multiple Sebaceous Gland Hyperplasias in a Cyclosporine (Ciclosporin)-Treated Renal Transplant Recipient

Coexistence of Basal Cell Carcinomas and Multiple Sebaceous Gland Hyperplasias in a Cyclosporine (Ciclosporin)-Treated Renal Transplant Recipient

Sebaceous lesions and their associated syndromes: Part I

Light and laser therapies for the treatment of sebaceous gland hyperplasia a review of the literature

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