Coexistence of Basal Cell Carcinomas and Multiple Sebaceous Gland Hyperplasias in a Cyclosporine (Ciclosporin)-Treated Renal Transplant Recipient

Abstract

A 55-year-old man presented with multiple, asymptomatic, yellowish papules on his face with a 4-year history, and two non-healing tumoral lesions on his nose with a 7-month history. He was a renal transplant recipient and had been treated with cyclosporine (ciclosporin) for 9 years. A biopsy from the asymptomatic, yellowish papule on the face showed sebaceous gland hyperplasia, and biopsies from the lesions on the nose revealed basal cell carcinomas. The lesions on the nose were excised. Sebaceous gland hyperplasia and skin cancers are among the cutaneous neoplasms observed in renal transplant recipients receiving cyclosporine. To our knowledge, this is the third reported case of the coexistence of basal cell carcinomas and multiple sebaceous gland hyperplasias in a cyclosporine-treated renal transplant recipient.

Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation

“…In the majority of cases, SH also occurs after many years of high-dose immunosuppressive therapy [6]. This contrasts with our patient who developed SH only a few months after starting cyclosporin treatment.…”

“…All of these patients were taking cyclosporin [2]. A few cases of disseminated SH secondary to cyclosporin therapy have been reported, among which there were 9 renal and 1 liver transplant recipients [4,5,6,7,8,9]. SH has been described in only 1 other bone marrow transplant recipient [10].…”

Study of dermatoses in kidney transplant patients

“…In Japanese transplant recipients, the skin cancers seem to be extremely rare. 22,23,24,25,26 Most of the patients with NMSC in this study (six patients with BCC and three with SCC), had undergone the transplantation more than five years before , in compliance with the literature and reinforcing the increase of the incidence of the neoplasms as the graft time elapses .…”