Ciclopirox Olamine 1% Cream A Preliminary Review of its Antimicrobial Activity and Therapeutic Use

Abstract

Ciclopirox olamine is a substituted pyridone antimycotic, unrelated to the imidazole derivatives, with activity against a broad spectrum of dermatophytes, yeasts, actinomycetes, molds, other fungi, and a variety of Gram-positive and Gram-negative bacteria. The efficacy of ciclopirox olamine cream has been demonstrated in open and placebo-controlled studies in patients with superficial dermatophyte or yeast infections, and in double-blind comparative trials in patients with dermatomycoses, topical ciclopirox olamine was comparable to or better than clotrimazole in efficacy and caused a similar number of side effects. Ciclopirox olamine penetrates through fingernails and in preliminary studies has been successfully used in onychomycoses. However, further studies are needed to establish the role of ciclopirox in the treatment of onychomycoses and dermatomycoses relative to that of the more recently introduced antigungal agents.

Antibacterial Chemical Constituent and Antiseptic Herbal Soap fromSalvinia auriculataAubl.

“…In summary, the strong inhibitory effects of the active extract of S. auriculata against S. aureus strains can be attributed to compound 1 , a 3,6-dioxygenated steroid, found primarily in aquatic plants [10]. Moreover, this activity may well be associated with a synergism with other compounds that have not yet been isolated from the active extract.…”

“…After incubation at 37°C for 24 h, inhibition zones were measured in millimeters and compared to the controls. The antibiotic ciclopirox olamine (Uci-Farma) was used as the positive control due to its antibacterial properties [10]. Dimethylsulfoxide (DMSO) was used as a negative control.…”

Current Insights into the Role of HIF-1 in Cutaneous Wound Healing

“…Ciclopirox olamine (CPX) is a commercially available antifungal agent, used widely to treat mycotic infections of the skin [82]. CPX can also chelate iron and induce activation of HIF-1 , nuclear accumulation of HIF-1 , DNA binding of HIF-1, and finally increased expression of HIF-1 target genes [83,84].…”

Treatment of intertriginous psoriasis: From the Medical Board of the National Psoriasis Foundation

“…Other antifungal agents including ciclopirox and naftifine, which are not imidazoles structurally, have antibacterial activity. 22 Topical ciclopirox and ketoconazole are Food and Drug Administrationeapproved for the treatment of seborrheic dermatitis. There may be an overlap of flexural psoriasis with seborrheic dermatitis.…”