Cicatricial Pemphigoid in a 6‐Year‐Old Child: Report of a Case and Review of the Literature

Abstract

Cicatricial pemphigoid has been documented previously in only four patients under the age of 20 years. We report a 6-year-old male who had erosions of the oral and genital mucosa, conjunctivitis, hoarseness, dysphagia, recurrent vomiting, and weight loss. Upper airway obstruction due to a chronically inflamed and scarred epiglottis necessitated tracheostomy. Biopsy of tissue from a solitary cutaneous lesion demonstrated a subepidermal bulla. Direct and indirect immunofluorescence confirmed a diagnosis of cicatricial pemphigoid. Therapy was begun consisting of prednisone, 2 mg per kg per day, in combination with dapsone, 2 mg per kg per day. He did not improve until the prednisone dosage was increased to 4 mg per kg per day.

Childhood oral pemphigoid: a case report and review of the literature

“…There are only 12 childhood CP cases, including ours, reported in the English language literature ( Table 1) and five of them are oral pemphigoid patients (12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Childhood CP shares similar clinical, histological and immunofluorescent features with the adult form.…”

Pilomatricoma in Elderly Individuals

“…Pilomatricomas are usually solitary tumors, but several lesions in patients have been reported [7, 16, 17]. Multiple pilomatricomas have been observed in association with Gardner’s syndrome [16, 18]. Furthermore, there are reports on the associated occurrence of pilomatricoma and myotonic dystrophy [19–21].…”

“…Although cases with a familial accumulation are on record, there are no certain indications for a hereditary ocurrence [7]. Pilomatricomas are usually solitary tumors, but several lesions in patients have been reported [7, 16, 17]. Multiple pilomatricomas have been observed in association with Gardner’s syndrome [16, 18].…”

Adolescent Oral Pemphigoid: Report of A Case and Review of Literature

“…There is no absolutely effective agent for MMP and the prognosis among childhood varies. 5,15,16 In addition to our case, literature has reported five childhood oral pemphigoid patients and it was striking to find out that all of them showed desquamative gingivitis as the only clinical manifestation. All six cases including ours have been treated successfully with corticosteroid therapy.…”