Childhood oral pemphigoid: a case report and review of the literature

Cheng, Yi-Shing Lisa; Rees, Terry D.; Wright, John M.; Plemons, Jacqueline M.

doi:10.1034/j.1600-0714.2001.300608.x

Cited by 24 publications

(21 citation statements)

References 32 publications

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“…The disease usually affects middle-aged or elderly females (2,(7)(8)(9)(10)(11)12). It can manifest as erosions of the non-keratinized mucosa or desquamation of the There are only 13 cases of childhood MMP reported in the English literature (Table I), 6 of them diagnosed as oral MMP (4,9,10,(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

“…Sklavounou & Laskaris (15) studied III patients with one ofthe following diseases: MMP, pemphigus vulgaris or bullous pemphigoid (BP) presenting with DG, and found that 64% of them were consistent with (17). erythema mtiltiforme and plasma cell gingivitis, may also present with DG (2,12,16). erythema mtiltiforme and plasma cell gingivitis, may also present with DG (2,12,16).…”

Section: Discussionmentioning

confidence: 99%

“…Prognosis oforal childhood MMP is good, although long-term follow-up is recommended (2,12). Ophthalmologica!…”

Section: Discussionmentioning

confidence: 99%

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Childhood Oral Mucous Membrane Pemphigoid Presenting as Desquamative Gingivitis in a 4-year-old Girl

Lourenço

Boggio²,

Martins³

et al. 2006

Acta Derm Venereol

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Mucous membrane pemphigoid is a chronic inflammatory, bullous subepithelial auto-immune disease, with predominant involvement of the mucosal surfaces. Oral mucous membrane pemphigoid occurring in childhood is extremely rare. We describe a new case of this entity occurring in a 4-year-old girl who presented with desquamative gingivitis. Diagnosis was based on clinical presentation, histopathology, immunofluorescence and immunoblotting examinations. Treatment and 2-year follow-up are described.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Childhood Oral Mucous Membrane Pemphigoid Presenting as Desquamative Gingivitis in a 4-year-old Girl

Lourenço

Boggio²,

Martins³

et al. 2006

Acta Derm Venereol

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“…Eine ethnische oder geografische Prädilektion konnte bisher nicht nachgewiesen werden [4]. Es handelt sich um eine Erkrankung des älteren Menschen mit einem mittleren Erkrankungsalter von 64 Jahren, selten sind auch jüngere Patienten betroffen [5].…”

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Das okuläre vernarbende Pemphigoid - aktuelle Aspekte zu Klinik und Therapie einer problematischen Erkrankung

Rübsam

Klein

Pleyer

2013

Klin Monatsbl Augenheilkd

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The ocular cicatricial pemphigoid (OCP) belongs to a family of chronically progressive autoimmune disorders, predominantly affecting mucous membranes (mucous membrane pemphigoids). It is an immunopathologically heterogeneous group of disorders with variable phenotypes that share the unique feature of a subepidermal blistering, through disruption of the adhesion between epidermis and dermis. A key feature is the chronically active inflammation with consecutive fibrosis, leading to a partial or complete loss of function of the affected organ. The ocular disease as a chronic cicatrising conjunctivitis is a common manifestation of the mucous membrane pemphigoid. The identification of the subtle pathology and the prompt initiation of an appropriate therapy are of pivotal importance. One purpose is to prevent further vision loss due to extensive corneal scarring and life-threatening systemic complications, such as the formation of oesophageal or tracheal strictures. So far there are no prospective, randomised studies, regarding the therapy guidelines with an evidence level more than III. The autoimmune nature of the disease implies that systemic immunosuppression is the only effective treatment option, most notably in extended stages. The aim of our study is to give a guideline for a stage adjusted therapy with conventional immunosuppressants and to give a perspective for alternative therapies, especially for recalcitrant disease.

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“…It is a clinical manifestation common to several diseases (Endo et al, 2008a;Lo Russo et al, 2008;. It is seen mainly in adults, especially women, although rare cases have been observed in children (Barnett et al, 1981;Cheng et al, 2001;Leao et al, 2008;Lo Russo et al, 2009;Yih et al, 1998). Nisengard and Levine (1995) cited the following as the standard for the clinical appearance of DG: 1) Gingival erythema not resulting from plaque, 2) Gingival desquamation, 3) Other intraoral and sometimes extraoral lesions, and 4) Complaint of sore mouth, particularly after eating spicy foods.…”

Section: Introductionmentioning

confidence: 99%