Cicatrices chéloïdes sur peau noire : mythe ou réalité

Allah, K.C.; Yeo, Samuel Chao Ming; Kossoko, H.; Djè, V. Assi Djè Bi; Kadio, M. Richard

doi:10.1016/j.anplas.2012.02.005

Cited by 20 publications

(10 citation statements)

References 26 publications

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“…Keloid scar of skin is a type of benign soft tissue skin tumor that originates from the proliferation of connective tissue subsequent to skin injury, and has high morbidity (1,2). The identification of some clinical biomarkers for keloid scars would be of great significance.…”

Section: Discussionmentioning

confidence: 99%

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Functional analysis of keratinocyte and fibroblast gene expression in skin and keloid scar tissue based on deviation analysis of dynamic capabilities

2016

Experimental and Therapeutic Medicine

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The aim of the present study was to select key genes that are associated with fibroblasts and keratinocytes during keloid scar progression and development. The gene expression profile of GSE44270, which includes 32 samples, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) in case samples compared with control samples were screened using the Limma R package followed by hierarchical clustering analysis. Protein-protein interaction (PPI) networks of the total selected DEGs were constructed using Cytoscape. Moreover, the Gene Ontology biological processes and significant Kyoto Encyclopedia of Genes and Genomes pathways of the total selected DEGs were enriched using the Database for Annotation, Visualization and Integrated Discovery. Significant pathways that may be associated with keloid scar were analyzed using deviation analysis of dynamic capabilities. There were 658 DEGs in fibroblast keloid vs. normal, 112 DEGs in fibroblast non-lesion vs. normal, 439 DEGs in fibroblast keloid vs. non-lesion, 523 DEGs in keratocyte keloid vs. normal, 186 DEGs in keratocyte non-lesion vs. normal, and 963 DEGs in keratocyte keloid vs. non-lesion groups. HOXA9, BMP4, CDKN1A and SMAD2 in fibroblasts, and HOXA7, MCM8, PSMA4 and PSMB2 in keratinocytes were key genes in the PPI networks. Moreover, the amino sugar and nucleotide sugar metabolism pathway, cell cycle, and extracellular matrix (ECM)-receptor interaction pathway were significant pathways. This study suggests that several key genes (BMP4, HOXA9, SMAD2, CDKN1A, HOXA7, PSMA4 and PSMB2) that participate in some significant pathways (cell cycle and ECM-receptor interaction pathways) may be potential therapeutic targets for keloid scars.

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Section: Discussionmentioning

confidence: 99%

“…Data show that the morbidity of keloid scars has been high in recent years, and female cases are more common than male cases (2). There are a variety of clinical treatment methods for keloids, including glucocorticoid injection under the skin, freezing, compression, ultrashort wave therapy, and simple surgery (3,4).…”

Section: Introductionmentioning

confidence: 99%

Functional analysis of keratinocyte and fibroblast gene expression in skin and keloid scar tissue based on deviation analysis of dynamic capabilities

2016

Experimental and Therapeutic Medicine

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“…Allah et al ( 16 ) performed surgical excision for 149 patients with keloids. The recurrence rate was 100%.…”

Section: Discussionmentioning

confidence: 99%

“…The authors concluded that keloids were not homogeneous biologic entities and were related with increased immunologic factors. The best prevention is to avoid the scar itself ( 16 ). Gurunluoglu et al ( 17 ) reported a case of clitoral keloid that developed after a traumatic laceration.…”

Section: Discussionmentioning

confidence: 99%

Clitoral keloids after female genital mutilation/cutting

Birge

Akbaş

Ozbey

et al. 2016

tjod

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We aimed to describe the presentation of long-term complications of female genital mutilation/cutting and the surgical management of clitoral keloids secondary to female genital mutilation/cutting. Twenty-seven women who underwent surgery because of clitoral keloid between May 2014 and September 2015 in Sudan Nyala Turkish Hospital were evaluated in this retrospective descriptive case series study. The prevalence of type 1, type 2, and type 3 female genital mutilation/cutting were 3.7%, 22.2%, and 74.1%, respectively (type 1: 1/27, type 2: 6/27, and type 3: 20/27). All patients had long-term health problems (dysuria, chronic pelvic pain, vaginal discharge, and chronic pruritus) and sexual dysfunction. Keloids were removed by surgical excision. There were no postoperative complications in any patient. Although clitoral keloid lesions can be seen after any type of female genital mutilation/cutting, they usually develop after type 3 female genital mutilation/cutting. Most of these keloids were noticed after menarche. Keloids can be removed by surgical excision and this procedure can alleviate some long-term morbidities of female genital mutilation/cutting.

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“…Genetic susceptibility is thought to play an integral role in the development of keloids . African Blacks and Asians are the most affected, while prevalence is the lowest among Whites . Furthermore, blood type A, hyper‐immunoglobulin E syndrome (high allergy risk), and hormone peaks (puberty, pregnancy) are considered risk factors.…”

Section: Introductionmentioning

confidence: 99%

An intra‐individual surgical wound comparison shows that octenidine‐based hydrogel wound dressing ameliorates scar appearance following abdominoplasty

Matiasek

Kienzl

Unger

et al. 2018

International Wound Journal

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Hypertrophic scar formation because of surgical procedures is associated with higher levels of pain, a lower quality of life, and poor cosmetic outcome and requires more resources in follow-up management. An octenidine-based hydrogel has been shown to modulate immunological function in an in vitro wound model, suggesting an improved scar formation. In this prospective, randomised, observer-blinded, and intra-patient-controlled study, 45 patients who underwent abdominoplasty or mastectomy with transverse rectus abdominis muscle (TRAM) flap reconstruction were given both a standard postoperative wound dressing on one wound side and an octenidine-based hydrogel with transparent film dressing, covered with standard postoperative dressing on the other side. Four instances of hypertrophia were reported in the gel side versus 12 in the standard dressing side. Visual Analogue Scale (VAS) pain scores taken during postoperative dressing changes showed reduced scores on the gel side at all time points. Vancouver Scar Scale (VSS) scores showed improvement in the gel side at 3, 6, and 12 months postoperatively. Skin distensibility measured using a cutometer showed significantly improved measures in gel-treated wounds, similar to measures of healthy skin. Trans-epidermal water loss (TEWL), measured using a tewameter, showed improved values on the gel side soon after surgery, with both the control and the gel side normalising after approximately 6 months. The octenidine-based wound dressing demonstrates improved wound healing associated with a lower incidence of hypertrophic scar formation.

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Cicatrices chéloïdes sur peau noire : mythe ou réalité

Cited by 20 publications

References 26 publications

Functional analysis of keratinocyte and fibroblast gene expression in skin and keloid scar tissue based on deviation analysis of dynamic capabilities

Functional analysis of keratinocyte and fibroblast gene expression in skin and keloid scar tissue based on deviation analysis of dynamic capabilities

Clitoral keloids after female genital mutilation/cutting

An intra‐individual surgical wound comparison shows that octenidine‐based hydrogel wound dressing ameliorates scar appearance following abdominoplasty

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