Churg–Strauss Syndrome Presenting with Acute Myocarditis and Cardiogenic Shock

Courand, Pierre‐Yves; Croisille, Pierre; Khouatra, C.; Cottin, Vincent; Kirkorian, Gilbert; Bonnefoy, Éric

doi:10.1016/j.hlc.2011.09.002

Cited by 35 publications

(22 citation statements)

References 21 publications

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“…[11] Our data suggest that risk of myocarditis is increased in patients between 20 and 30 years old and cardiac manifestations occur later in females than males. CSS patients usually have asthma, whereas leukotriene receptor antagonists may be involved in the onset of CSS.…”

Section: Discussionmentioning

confidence: 91%

A case report and literature review of Churg–Strauss syndrome presenting with myocarditis

Qiao

Gao

2016

Medicine

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Background:Churg–Strauss syndrome (CSS) is a multisystem disorder characterized by asthma, prominent peripheral blood eosinophilia, and vasculitis signs.Case summary:Here we report a case of CSS presenting with acute myocarditis and heart failure and review the literature on CSS with cardiac involvement. A 59-year-old man with general fatigue, numbness of limbs, and a 2-year history of asthma was admitted to the department of orthopedics. Eosinophilia, history of asthma, lung infiltrates, peripheral neurological damage, and myocarditis suggested the diagnosis of CSS. Transthoracic echocardiography revealed a dilated hypokinetic left ventricle (left ventricular ejection fraction ∼40%) with mild segmental abnormalities in the septal and apical segments.Conclusion:By reviewing the present case reports, we concluded that (1) the younger age of CSS, the greater occurrence rate of complicating myocarditis and the poorer prognosis; (2) female CSS patients are older than male patients; (3) patients with cardiac involvement usually have a history of severe asthma; (4) markedly increased eosinophil count suggests a potential diagnosis of CSS (when the count increases to 20% of white blood cell counts or 8.1 × 109/L, eosinophils start to infiltrate into myocardium); and (5) negative ANCA status is associated with heart disease in CSS.

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Section: Discussionmentioning

confidence: 91%

A case report and literature review of Churg–Strauss syndrome presenting with myocarditis

Qiao

Gao

2016

Medicine

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“…Myocarditis is autoimmune if no infectious agents are identified on EMB and other known causes are excluded (box 1). 23 24 Autoimmune myocarditis may occur with exclusive cardiac involvement or in systemic autoimmune disorders, in which it is often associated with a bad prognosis,25 – 29 particularly in Churg–Strauss syndrome,25 29 Wegener granulomatosis,26 idiopathic inflammatory myopathies,28 systemic lupus erythematosus27 and is managed with intensified immunosuppression 24–29…”

Section: Aetiologymentioning

confidence: 99%

Clinical presentation and diagnosis of myocarditis

Caforio

Basso

Iliceto

2015

Heart

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“…Potential causative agents should be stopped, and early intervention with supportive treatment to maintain haemodynamic stability is important. Corticosteroids are the only routinely used treatment for EM, with a good response seen in the majority of cases, although the evidence of benefit for this response is limited to observational case series and reports . The dosing and duration of the corticosteroids use remain controversial .…”

Section: Discussionmentioning

confidence: 99%

“…Hypersensitivity reactions occur particularly to medications, including penicillins, sulphonamides and dobutamine, and can be early or delayed after initiation of these medications. [6][7][8][9] Vasculitides, especially Churg-Strauss syndrome, have been implicated. 5,6,10 Other associated causes include parasitic infections, granulomatous conditions, idiopathic hypereosinophilic syndrome, transplant rejection and malignancies, such as leukaemia.…”

Section: Discussionmentioning

confidence: 99%