Clinical presentation and diagnosis of myocarditis

Caforio, Alida L.P.; Basso, Cristina; Iliceto, Sabino

doi:10.1136/heartjnl-2014-306363

Cited by 84 publications

(76 citation statements)

References 107 publications

(243 reference statements)

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“…A myocardial sample is commonly obtained transvascularly from the right or left ventricle using endomyocardial biopsy (EMB). EMB is considered the gold standard for myocarditis diagnosis and is also the only method able to confirm a final diagnosis in vivo [6][7][8][9][10] . According to the WHO / ISCF definition of 1995 diagnosis of myocarditis is based on histological, immunological and immunohistochemical criteria 11 .…”

Section: Introductionmentioning

confidence: 99%

“…Other possible causes of myocarditis are autoimmune or toxic factors. Autoimmunity is a possible reaction to the initial viral damage of myocytes and is considered one of the main causes of LV function impairment in the second phase of the disease 10,21,22 . Immunohistochemical methods for EMB evaluation have shown that in 40-50% of DCM cases, myocarditis is present 23,24 .…”

Section: Introductionmentioning

confidence: 99%

“…It is estimated that in about 50-70% of patients, the healing of myocarditis is associated with the improvement or normalization of LV systolic function. On the other hand, in some cases, LV dysfunction persists or even progresses to refractory failure 4,5,[7][8][9][10]28 . There are a number of factors that play a role in the course of the disease, for instance type of myocarditis, grade of initial myocardial injury, hormonal factors, physical stress during the acute phase of the disease, the intensity and duration of the inflammatory process and persistence or replication of the virus in the myocardium 5,7,9,10,[28][29][30] .…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, in some cases, LV dysfunction persists or even progresses to refractory failure 4,5,[7][8][9][10]28 . There are a number of factors that play a role in the course of the disease, for instance type of myocarditis, grade of initial myocardial injury, hormonal factors, physical stress during the acute phase of the disease, the intensity and duration of the inflammatory process and persistence or replication of the virus in the myocardium 5,7,9,10,[28][29][30] . Although a number of studies have focused on prognostic indicators 6,25,[29][30][31][32] , we have no clear and convincing evidence that will allow us to stratify patients at the time of diagnosis and to tailor additional medical care, including the use of advanced and expensive methods of current medicine, i.e.…”

Section: Introductionmentioning

confidence: 99%

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Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

Krejčí¹,

Hude²,

Ozábalová³

et al. 2016

BIOMED PAP

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, Lenka Spinarova aAims. To compare the differences between patients with inflammatory cardiomyopathy (ICM) with and without improvement in left ventricular (LV) systolic function and to identify the relevant predictors of LV improvement. Patients and Methods. The study included 63 patients with biopsy-proven ICM and heart failure symptoms of at least NYHA II, symptom duration ≤ 6 months, LV ejection fraction (LVEF) ≤ 40% assessed by echocardiography and presence of >14 mononuclear leukocytes (LCA+ cells)/mm 2 in biopsy samples. Patients were evaluated at baseline and after 6 months. Results. In the group with LVEF improvement of ≥ 10% (I+ group, n = 41), LVEF increased from 24 ± 7% to 47 ± 8% (P < 0.001). In 22 patients (group I-), there was no or minimal LVEF increase (< 10%). In the I+ group, there were more LCA+ cells/mm 2 at baseline (25.1 ± 16.5 vs. 18.5 ± 4.4 cells/mm 2 ; P = 0.032) and a more significant decrease in LCA+ cells in the follow-up (reduction of 13.6 ± 14.3 cells/mm 2 vs. 5.0 ± 7.7 cells/mm 2 in the I-group; P = 0.009). The univariate logistic regression showed a possible association of number of LCA+ cells, LV end-diastolic diameter and N-terminal fragment of pro-brain natriuretic peptide (NTproBNP) value with LVEF improvement. In the multivariate analysis, only NTproBNP at diagnosis was confirmed as an independent predictor of LVEF improvement (OR=1.2; 1.003 to 1.394; P = 0.046). Conclusion. The LV systolic function improvement was observed in 65% of the patients. In these patients, the number of inflammatory cells at baseline was higher and decreased more but the higher baseline NTproBNP value was the only independent predictor of LVEF improvement.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

Krejčí¹,

Hude²,

Ozábalová³

et al. 2016

BIOMED PAP

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“…A few patients even have severe cardiac arrhythmia or fatal heart failure (Canter and Simpson, 2014;Pettit et al, 2014). Currently, the pathogenesis mechanism of myocarditis is still under investigation, but it is known to be related to multiple factors including viral infection, oxidative damage, and cell apoptosis (Ramachandra et al, 2010;Caforio et al, 2015;Ladani et al, 2015). FAS/FASL-induced cell apoptosis is one of the major mechanisms underlying myocardial cell injury (Guo et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Expression of miR-98 in myocarditis and its influence on transcription of the FAS/FASL gene pair

2016

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ABSTRACT. Myocarditis is a common cardiovascular disease and frequently occurs in children and teenagers. It is believed to be caused by both endogenous and exogenous factors, among which FAS/FASL gene pair-induced cell apoptosis is a major mechanism of myocardial cell injury. A previous study has detected low expression of microRNA (miR)-98 in myocarditis patients. Therefore, in this study we investigated the functional implications of miR-98 with respect to the disease. We carried out a case-control study including 50 myocarditis patients and 50 healthy individuals. Total RNA was extracted from peripheral blood plasma. Expression levels of miR-98 and the FAS/FASL gene pair were determined by real-time fluorescent quantitative polymerase chain reaction. The interaction between miR-98 and the FAS/FASL pair was visualized by dual-luciferase reporter assay. The expression of the FAS/ FASL gene pair was further detected by transfecting with an miR-98 mimic or an miR-98 inhibitor. The content of miR-98 in the peripheral blood of the myocarditis patients was significantly lower than in the

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Myocarditis and Pregnancy

Shotan

A²

2019

Cardiac Problems in Pregnancy, 4th Edition

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Clinical presentation and diagnosis of myocarditis

Cited by 84 publications

References 107 publications

Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

Expression of miR-98 in myocarditis and its influence on transcription of the FAS/FASL gene pair

Myocarditis and Pregnancy

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