Churg-Strauss syndrome and leukotriene antagonist use: a respiratory perspective

Abstract

ABSTRACT

Churg Strauss Syndrome after Polypectomy Procedure and on and off Prescription of Monteleukast: Case Report

“…Mean age was 47 years and 55% were female. Most patients developed CSS within 6 months of LTA treatment [8].…”

Churg–Strauss syndrome with severe granulomatous angiitis and crescentic glomerulonephritis, which developed during therapy with a leukotriene receptor antagonist

“…Recently, potentially causal association between LTRA treatment and CSS has been recognized through observation of a clear temporal relationship between initiation of LTRAs and progression of CSS among patients with or without corticosteroids [14]. Most recently, Bibby et al [15] analyzed the database of the US Food and Drug Administration (FDA) Adverse Event Reporting System (AERS), concluding that LTRA treatment was a suspect medication in most cases of CSS reported in the database.…”

Update on vasculitis

“…In a retrospective analysis of 62 patients who had CSS while taking LTAs, 57 had CSS within the first year of starting LTAs, and 48 had CSS within 6 months. 59 In 2 cases re-exposure to LTAs was associated with recurrence of CSS within 2 weeks, despite a steady dose of glucocorticoids. A possible CBC every week for the first month, every 2 wk for the second month, and every 4 wk thereafter Pregnancy testing in women of child-bearing potential before initiation Effective contraception DXA, Dual energy X-ray absorptiometry; CBC, complete blood count; WBC, white blood cell count; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TPMT, thiopurine methyltransferase.…”