Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice

Zhao, Yang; Fang, Yinchun; Zhao, Haiping; Li, Jincheng; Duan, Yunyun; Shi, Wenjuan; Huang, Yuyou; Gao, Li; Luo, Yumin

doi:10.1016/j.ejphar.2017.10.016

Cited by 46 publications

(33 citation statements)

References 47 publications

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“…In addition, chrysophanol inhibited neuronal apoptosis by inhibited activation of caspase‐3 in I/R mice . Latest research showed chrysophanol protected nerve cell by reducing neuronal endoplasmic reticulum stress, including down‐regulating the expression of glucose‐regulated protein 78 (GRP78), eukaryotic initiation factor 2 alpha (p‐eIF2α), C/EBP homologous protein (CHOP) and caspase‐12, while increasing the level of inhibitor of NF‐κB‐α (IκB‐α) . Therefore, Wang et al .…”

Section: Pharmacologymentioning

confidence: 99%

“…[11] Latest research showed chrysophanol protected nerve cell by reducing neuronal endoplasmic reticulum stress, including down-regulating the expression of glucose-regulated protein 78 (GRP78), eukaryotic initiation factor 2 alpha (p-eIF2a), C/EBP homologous protein (CHOP) and caspase-12, while increasing the level of inhibitor of NF-jB-a (IjB-a). [12] Therefore, Wang et al [13] believed that chrysophanol could be used to treat traumatic brain injury.…”

Section: Pharmacology Neuroprotective Activitymentioning

confidence: 99%

“…Male C57BL mice 0.1 mg/kg In vivo [12] Promotes lead excretion and reducing peroxide content Adult Kunming mice 10.0 mg/kg In vivo [14] Reduces the expression of cleaved caspase-3 and enhances the activity of SOD and MnSOD Male C57BL mice 0.1-10 mg/kg In vivo [15] Inhibition of inflammation in the hippocampus Male wild-type ICR mice 10 mg/kg In vivo [66] Antioxidant and anti-inflammatory Murine BV2 cells 0-50 lM In vitro [51] Inhibition of Drp1-dependent mitochondrial fission BV-2 murine microglial cells…”

Section: Suppress the Activation Of Nalp3 Inflammasomementioning

confidence: 99%

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Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Xie

Tang

Song

et al. 2019

Journal of Pharmacy and Pharmacology

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Objective Chrysophanol is a natural anthraquinone, also known as chrysophanic acid and 1,8‐dihydroxy‐3‐methyl‐anthraquinone. It has been widely used in the food and pharmaceutical fields. This review is intended to provide a comprehensive overview of the pharmacology, toxicity and pharmacokinetic researches of chrysophanol. Key finding Information on chrysophanol was collected from the Internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library and Europe PM using a combination of keywords including ‘pharmacology’, ‘toxicology’ and ‘pharmacokinetics’. The literature we collected included from January 2010 to June 2019. Chrysophanol has a wide spectrum of pharmacological effects, including anticancer, antioxidation, neuroprotection, antibacterial and antiviral, and regulating blood lipids. However, chrysophanol has obvious hepatotoxicity and nephrotoxicity, and pharmacokinetics indicate that the use of chrysophanol in combination with other drugs can reduce toxicity and enhance efficacy. Summary Chrysophanol can be used in many diseases. Future research directions include how the concentration of chrysophanol affects pharmacological effects and toxicity; the mechanism of synergy between chrysophanol and other drugs.

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Section: Pharmacologymentioning

confidence: 99%

Section: Pharmacology Neuroprotective Activitymentioning

confidence: 99%

Section: Suppress the Activation Of Nalp3 Inflammasomementioning

confidence: 99%

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Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Xie

Tang

Song

et al. 2019

Journal of Pharmacy and Pharmacology

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“…Naturally occurring anthraquinone compounds include physcion, emodin, aloe‐emodin, rhein and chrysophanol (1,8‐Dihydroxy‐3‐methyl‐9,10‐anthraquinone). Chrysophanol has anti‐inflammatory, neuroprotective, antibacterial, cardiac protective and anti‐depressant effects. In addition, it has shown strong anti‐neoplastic effects in breast cancer, non‐small cell lung cancer (NSCLC), and hepatocellular carcinoma (HCC) cells through different mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Chrysophanol exhibits inhibitory activities against colorectal cancer by targeting decorin

Deng

Xue

et al. 2019

Cell Biochemistry & Function

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Colorectal cancer (CRC) is a common human malignancy that accounts for 600,000 deaths annually worldwide. Chrysophanol, a naturally occurring anthraquinone compound, exhibits anti-neoplastic effects in various cancer cells. The aim of this study was to explore the biological effects of chrysophanol on CRC cells, and determine the underlying mechanism. Chrysophanol inhibited proliferation of and promoted apoptosis in CRC cells by activating the intrinsic mitochondrial apoptotic pathway.In addition, chrysophanol also suppressed tumor growth in vivo and increased the percentage of apoptotic cells in tumor xenografts, without general toxicity. Proteomic iTRAQ analysis revealed decorin (DCN) as the major target of chrysophanol. DCN was upregulated in the tumor tissues following chrysophanol treatment, and ectopic DCN expression markedly augmented the pro-apoptotic effects of chrysophanol in CRC cells. In contrast, DCN knockdown significantly abrogated chrysophanolinduced apoptosis in CRC cells. Taken together, chrysophanol exerts anti-neoplastic effects in vitro and in vivo in CRC cells by modulating DCN, there by highlighting its therapeutic potential in CRC.

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“…Naturally occurring anthraquinone compounds constitute a large family including physcion, emodin, aloe‐emodin, rhein, and chrysophanol (1,8‐dihydroxy‐3‐methyl‐9,10‐anthraquinone). A variety of pharmacological activities of chrysophanol such as anti‐inflammatory (Jeong et al, ; Wen et al, ), neuroprotective (Zhao et al, ; Zhao et al, ), antibacterial (Orban‐Gyapai et al, ), cardiac protective (Lian et al, ), and anti‐depressant (Zhang et al, ) activities have been reported. Interestingly, the anti‐neoplastic activities of chrysophanol have also been reported.…”

mentioning

confidence: 99%

Chrysophanol Suppresses Hypoxia‐Induced Epithelial‐Mesenchymal Transition in Colorectal Cancer Cells

Deng

Xue

et al. 2019

The Anatomical Record

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Colorectal cancer (CRC) is a common human malignancy, accounting for 600,000 death cases annually worldwide. Chrysophanol is a naturally occurring anthraquinone compound and exhibits anti-neoplastic activities. This study aims to explore the biological effects of chrysophanol on CRC metastasis and the relevant underlying mechanism. Cell proliferation assay, wound scratch assay, and Transwell invasion assay were used to examine the effect of chrysophanol on proliferation, migration, and invasion of CRC cells. Hypoxiainducible factor-1α (HIF-1α) shRNA was utilized to transfect CRC cells to examine the role of HIF-1α in chrysophanol suppression of hypoxia-induced epithelial to mesenchymal transition (EMT). The suppression effect of chrysophanol on hypoxia-induced EMT in vivo was also validated in xenograft tumor models. In the present study, our findings indicated that chrysophanol has the capability to suppress hypoxia-induced EMT in CRC in vitro and in vivo, and the possible mechanism involved is the inhibition of HIF-1α via modulating PI3k/Akt signaling pathway. Collectively, the results indicated that chrysophanol can be used as an EMT and cancer metastasis inhibitor in the treatment of CRC. Anat Rec, 302:1561-

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Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice

Cited by 46 publications

References 47 publications

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Chrysophanol exhibits inhibitory activities against colorectal cancer by targeting decorin

Chrysophanol Suppresses Hypoxia‐Induced Epithelial‐Mesenchymal Transition in Colorectal Cancer Cells

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