Chrysin protects against cerebral ischemia-reperfusion injury in hippocampus via restraining oxidative stress and transition elements

Shang, Jinfeng; Jiao, Jiakang; Yan, Mingxue; Wang, Jingyi; Li, Qiannan; Shabuerjiang, Lizha; Lu, Yinghui; Song, Qi; Bi, Lei; Huang, Guijinfeng; Zhang, Xiaolu; Wen, Yinlian; Cui, Yuying; Wu, Kai; Li, Gongyu; Wang, Peng; Liu, Xin

doi:10.1016/j.biopha.2023.114534

Cited by 11 publications

(6 citation statements)

References 87 publications

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“…The results revealed that chrysin has the ability to antagonize the tert‐butyl hydroperoxide in the SH‐SY5Y cell line and induce potential in vitro and in vivo neuroprotection against AlCl 3 ‐induced lipid peroxidation and Fenton reaction in the SH‐SY5Y cells and impairment of the levels of antioxidant enzymes, SOD and CAT, in the in vivo mouse model [56] . This activity could be explained by the ability of chrysin to chelate the transition metal ions and reduced the prooxidant enzymes, [37] as the chrysin also reported for its ability to regulated and restrained the transition metals levels, e. g., Fe, Cu, and Zn, in the rats brain leading to protection against cerebral ischemia reperfusion injury in the rats model [57] …”

Section: Antioxidant Activity Of Chrysinmentioning

confidence: 92%

“…[56] This activity could be explained by the ability of chrysin to chelate the transition metal ions and reduced the prooxidant enzymes, [37] as the chrysin also reported for its ability to regulated and restrained the transition metals levels, e. g., Fe, Cu, and Zn, in the rats brain leading to protection against cerebral ischemia reperfusion injury in the rats model. [57] Therefore, the in vitro antioxidant activity of chrysin is mostly attributed to the metal chelating effect of the compound or the competition of the compound with the xanthine oxidase enzyme; however, the direct capturing activity of chrysin on the free radical is weak compared to the common antioxidant flavonoids (Figure 3).…”

Section: In Vitro Antioxidant Activity Of Chrysinmentioning

confidence: 99%

“…[58] The neuroprotective effect of chrysin is also attributed to the compound's ability to reduce the levels of transition metals, e. g., Fe, Cu, and Zn, associated with oxidative stress in the brain, an effect that is attributed to the protective effect of chrysin against the injury in cerebral ischemia reperfusion in the rat model. [57] Chrysin is also reported to protect against aluminum phosphide-induced cardiovascular complications by reducing oxidative stress and mitochondrial damage. [59] In that model, chrysin has induced potential changes in the antioxidant (e. g., GSH) and oxidizing (e. g., GSSG and MDA) biomarker contents.…”

Section: In Vivo Antioxidant Activity Of Chrysinmentioning

confidence: 99%

“…Therefore, the protective effect of chrysin on the cognitive decline in aged mice has been attributed to the antioxidant activity of the compound and the compound′s ability to increase the aged‐related decline level of the brain‐derived neurotrophic factor (BDNF) [58] . The neuroprotective effect of chrysin is also attributed to the compound′s ability to reduce the levels of transition metals, e. g., Fe, Cu, and Zn, associated with oxidative stress in the brain, an effect that is attributed to the protective effect of chrysin against the injury in cerebral ischemia reperfusion in the rat model [57] . Chrysin is also reported to protect against aluminum phosphide‐induced cardiovascular complications by reducing oxidative stress and mitochondrial damage [59] .…”

Section: Antioxidant Activity Of Chrysinmentioning

confidence: 99%

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Chrysin, The Flavonoid Molecule of Antioxidant Interest

Mohammed,

Sulaiman,

Albukhaty

et al. 2023

ChemistrySelect

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Chrysin, the natural bioactive flavone compound, has been identified in several edible materials such as honey, propolis, and passionflower with numerous biological potentials and pharmaceutical effects including antitumor, anti‐inflammatory, antiviral and antioxidant. The compound has been reported to have lower in vitro antioxidant activity compared to other flavone‐based structures such as quercetin, luteolin, and myricetin, which is mostly attributed to the higher hydroxylation and the presence of conjugated en‐diol structures in these flavonoids and the lack of these structural features in chrysin. On the contrary to the in vitro antioxidant effect of chrysin, the compound has exerted remarkable in vivo antioxidant activities in several models related to the liver, brain, heart, kidneys, and other soft tissues. The current review includes a discussion of the in vivo and in vitro antioxidant activity of chrysin compared to other common flavonoids. The study also covers subjects linked to chrysin antioxidants, such as its metabolism, bioavailability, and current formulations that aim to increase chrysin antioxidant impact and overcome its low bioavailability.

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Section: Antioxidant Activity Of Chrysinmentioning

confidence: 92%

Section: In Vitro Antioxidant Activity Of Chrysinmentioning

confidence: 99%

Section: In Vivo Antioxidant Activity Of Chrysinmentioning

confidence: 99%

Section: Antioxidant Activity Of Chrysinmentioning

confidence: 99%

See 2 more Smart Citations

Chrysin, The Flavonoid Molecule of Antioxidant Interest

Mohammed,

Sulaiman,

Albukhaty

et al. 2023

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…Flavonoid monomers, in addition to their antioxidant effects, have been found to reduce oxidative stress in the MCAO/R rat model. Chrysin, for example, increased SOD levels and inhibited MDA expression after 5 days of administering a dose of 50 mg/kg ( Shang et al, 2023 ). Similarly, eriocitrin was observed to provide protection against CIRI.…”

Section: Protective Mechanism Of Traditional Chinese Medicine Monomer...mentioning

confidence: 99%

Role of traditional Chinese medicine monomers in cerebral ischemia/reperfusion injury:a review of the mechanism

Zheng,

Jiang,

Huang

et al. 2023

Front. Pharmacol.

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Ischemia/reperfusion (I/R) injury is a pathological process wherein reperfusion of an ischemic organ or tissue exacerbates the injury, posing a significant health threat and economic burden to patients and their families. I/R triggers a multitude of physiological and pathological events, such as inflammatory responses, oxidative stress, neuronal cell death, and disruption of the blood-brain barrier (BBB). Hence, the development of effective therapeutic strategies targeting the pathological processes resulting from I/R is crucial for the rehabilitation and long-term enhancement of the quality of life in patients with cerebral ischemia/reperfusion injury (CIRI). Traditional Chinese medicine (TCM) monomers refer to bioactive compounds extracted from Chinese herbal medicine, possessing anti-inflammatory and antioxidative effects, and the ability to modulate programmed cell death (PCD). TCM monomers have emerged as promising candidates for the treatment of CIRI and its subsequent complications. Preclinical studies have demonstrated that TCM monomers can enhance the recovery of neurological function following CIRI by mitigating oxidative stress, suppressing inflammatory responses, reducing neuronal cell death and functional impairment, as well as minimizing cerebral infarction volume. The neuroprotective effects of TCM monomers on CIRI have been extensively investigated, and a comprehensive understanding of their mechanisms can pave the way for novel approaches to I/R treatment. This review aims to update and summarize evidence of the protective effects of TCMs in CIRI, with a focus on their role in modulating oxidative stress, inflammation, PCD, glutamate excitotoxicity, Ca2+ overload, as well as promoting blood-brain barrier repairment and angiogenesis. The main objective is to underscore the significant contribution of TCM monomers in alleviating CIRI.

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Effect of berberine on the hippocampal structure, biochemical factors, memory, and blood–brain barrier in rat model of transient global cerebral ischemia

Mehboodi,

Shahedi,

Namavar

et al. 2024

Phytotherapy Research

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Global cerebral ischemia (GCI) results in damage to the neurons and leads to cognitive impairments. Berberine (BBR) is known for its neuroprotective qualities. This study aimed to investigate the effects of BBR on memory, Blood–brain barrier (BBB) permeability, biochemical factors, and neuronal structure. Sixty‐three adult male Wistar rats were divided randomly into Sham (21), GCI (21), and GCI + BBR (21) groups. The GCI + BBR group received 50 mg/kg of BBR for 7 days before and 6 h after 20 min of GCI induction. After 24 h, assessments included hippocampal neuronal structure, catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GPX) levels, memory performance, and BBB permeability. The GCI + BBR group reduced volume loss in the CA1 and its sublayers (oriens, pyramidal, and radiatum) compared to the GCI group (p < 0.0001, p < 0.001, p < 0.01 and p < 0.001, respectively). Additionally, the GCI + BBR group showed higher pyramidal neuron density (p < 0.0001) and number (p < 0.0001) compared to the GCI group. BBR also decreased MDA levels (p < 0.0001) and increased CAT activity (p < 0.0001) in the GCI + BBR group compared to the GCI group, with GPX and SOD activity approaching Sham levels (p < 0.0001, both). BBR demonstrated significant improvements in short and long‐term memory compared to the GCI group (p < 0.01, p < 0.0001, respectively). Furthermore, BBB permeability in the GCI + BBR group was significantly reduced compared to the GCI group (p < 0.0001). These findings demonstrated BBR's potential to protect the neurons in the CA1 and BBB structures, enhance antioxidant activity, and alleviate GCI‐induced memory impairments.

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Chrysin protects against cerebral ischemia-reperfusion injury in hippocampus via restraining oxidative stress and transition elements

Cited by 11 publications

References 87 publications

Chrysin, The Flavonoid Molecule of Antioxidant Interest

Chrysin, The Flavonoid Molecule of Antioxidant Interest

Role of traditional Chinese medicine monomers in cerebral ischemia/reperfusion injury:a review of the mechanism

Effect of berberine on the hippocampal structure, biochemical factors, memory, and blood–brain barrier in rat model of transient global cerebral ischemia

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