Effect of berberine on the hippocampal structure, biochemical factors, memory, and blood–brain barrier in rat model of transient global cerebral ischemia
Dariush Mehboodi,
Abbas Shahedi,
Mohammad Reza Namavar
et al.
Abstract:Global cerebral ischemia (GCI) results in damage to the neurons and leads to cognitive impairments. Berberine (BBR) is known for its neuroprotective qualities. This study aimed to investigate the effects of BBR on memory, Blood–brain barrier (BBB) permeability, biochemical factors, and neuronal structure. Sixty‐three adult male Wistar rats were divided randomly into Sham (21), GCI (21), and GCI + BBR (21) groups. The GCI + BBR group received 50 mg/kg of BBR for 7 days before and 6 h after 20 min of GCI inducti… Show more
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