Chronotherapy: Resetting the Circadian Clocks of Patients with Delayed Sleep Phase Insomnia

Czeisler, Charles A.; Richardson, Gary S.; Coleman, Richard M.; Zimmerman, Janet C.; Moore‐Ede, Martin C.; Dement, William C.; Weitzman, Elliot D.

doi:10.1093/sleep/4.1.1

Cited by 326 publications

(122 citation statements)

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“…This poor compensatory function for sleep loss may account for the well-acknowledged but poorly explained fact that efforts to rise earlier and the consequent shortening of sleep duration do not allow the patient to fall asleep earlier. 1 14. By two-way repeated ANOVA with Greehouse-Geisser correction, sleep propensity was higher in DSPS than in controls (df=1, p<0.0001), with a significant time-course difference (df=23, e=0.24, p<0.0001) and interaction (df=23, e=0.24, p<0.0001).…”

Section: Discussionmentioning

confidence: 87%

Poor Compensatory Function for Sleep Loss as a Pathogenic Factor in Patients with Delayed Sleep Phase Syndrome

Uchiyama

Okawa

Shibui

et al. 2000

Sleep

101

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Section: Discussionmentioning

confidence: 87%

Poor Compensatory Function for Sleep Loss as a Pathogenic Factor in Patients with Delayed Sleep Phase Syndrome

Uchiyama

Okawa

Shibui

et al. 2000

Sleep

101

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“…Once this objective is achieved, the individual is advised to maintain a regular sleep/wake schedule rigorously, repeating the process as necessary. Although there are positive case reports describing the use of chronotherapy for delayed sleep phase disorder, 103 there have been no controlled trials of its efficacy or safety. One study assessing the long-term efficacy of this strategy reported that relapse was common.…”

Section: Chronotherapymentioning

confidence: 99%

Circadian rhythm sleep disorders

Kolla¹,

Auger²,

Morgenthaler³

2012

CPT

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Misalignment between endogenous circadian rhythms and the light/dark cycle can result in pathological disturbances in the form of erratic sleep timing (irregular sleep-wake rhythm), complete dissociation from the light/dark cycle (circadian rhythm sleep disorder, free-running type), delayed sleep timing (delayed sleep phase disorder), or advanced sleep timing (advanced sleep phase disorder). Whereas these four conditions are thought to involve predominantly intrinsic mechanisms, circadian dysrhythmias can also be induced by exogenous challenges, such as those imposed by extreme work schedules or rapid transmeridian travel, which overwhelm the ability of the master clock to entrain with commensurate rapidity, and in turn impair approximation to a desired sleep schedule, as evidenced by the shift work and jet lag sleep disorders. This review will focus on etiological underpinnings, clinical assessments, and evidence-based treatment options for circadian rhythm sleep disorders. Topics are subcategorized when applicable, and if sufficient data exist. The length of text associated with each disorder reflects the abundance of associated literature, complexity of management, overlap of methods for assessment and treatment, and the expected prevalence of each condition within general medical practice.

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“…Some times she delayed her sleep phase 2-3 h each day to adjust it to the desired cycle. This method, which was essentially similar to chronotherapy [3], was useful for adjusting her sleep phase to the desired time.But, the effect was only temporary and maintenance of the desired rhythm was difficult for her and the sleep phase was delayed again whithin a few days.…”

Section: Delayed Sleep Phase Syndrome (Dsps)mentioning

confidence: 99%

“…She succeeded in both advancing her sleep phase and maintaining it at the desired time for more than 2 months (Fig 1-b). 3. Case 3: A 24-year college student (Irregular sleep-wake pattern):…”

Section: Delayed Sleep Phase Syndrome (Dsps)mentioning

confidence: 99%