Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
There are several circulated hormones that control intravascular blood volume which are secreted from cardiac tissue, such as atrial natriuretic peptide (ANP) and brain (B-type) natriuretic peptide (BNP). These peptides will be elevated in case of heart failure (HF), and because of their diuretic, natriuretic, vasodilating effects as well as suppressing renin production they will work as compensated for HF. The natriuretic peptides system has critical effect against renin – angiotensin – aldosterone system (RAAS). A suggested therapeutic approach was discussed in HF treatment via performing human recombinant ANP and BNP, but it’s requiring more clinical trials to evaluate the quality of this approach compared to conventional treatment.
There are several circulated hormones that control intravascular blood volume which are secreted from cardiac tissue, such as atrial natriuretic peptide (ANP) and brain (B-type) natriuretic peptide (BNP). These peptides will be elevated in case of heart failure (HF), and because of their diuretic, natriuretic, vasodilating effects as well as suppressing renin production they will work as compensated for HF. The natriuretic peptides system has critical effect against renin – angiotensin – aldosterone system (RAAS). A suggested therapeutic approach was discussed in HF treatment via performing human recombinant ANP and BNP, but it’s requiring more clinical trials to evaluate the quality of this approach compared to conventional treatment.
In the present study, an attempt was made to prepare a pulsincap chronomodulated drug delivery system for the treatment of asthma and associated early morning allergy. Pulsincap capsule was prepared by sealing the drug nanosuspension inside the formaldehyde treated insoluble capsule bodies with a swellable and erodible guar gum plug. The drug, Montelukast sodium (MLS) nanosuspension was prepared by emulsion-solvent evaporation method using HPMC E15 and sodium lauryl sulphate (SLS). Nanosuspension formulations were optimized by using statistical Central composite design (CCD) for the required size and stability. The entire capsules were enteric coated using Cellulose acetate phthalate (CAP). This enteric coat prevents the drug release in the stomach, further the swellable hydrogel plug protect the nanosuspension to maintain the lag phase (5h) and facilitate its burst release in the colon. The length of this lag phase depends upon the concentration and quantity of the hydro gel plug. In order to simulate the GIT environment, the dissolution studies were performed using a sequential pH change method. DSC studies confirmed the absence of drug-excipient interactions. From the design space provided by the CCD, F14 and F15 formulations were considered as optimized. SEM studies were conducted for F14 formulation and this was filled in the Chronomodulated pulsincap systems (CMPs). These CMPs showed the drug release after 5h lag phase. Hence, when CMPs containing MLS nanosuspension is administered during bed time, it starts releasing the drug at the early morning hours to reduce asthma and associated early morning allergies like rhinitis and sneezing. Further, extensive in vivo studies are needed to be conducted to confirm the efficiency of these CMPs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.