Chronology of labyrinthitis ossificans induced by <i>streptococcus pneumoniae</i> meningitis

Nabili, Vishad; Brodie, Hilary A.; Neverov, N I; Tinling, Steven P.

doi:10.1097/00005537-199906000-00017

Cited by 45 publications

(40 citation statements)

References 18 publications

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“…There are papers that demonstrate that ossifi cation can occur as early as 2 months after meningitis (Novak et al, 1990) on computed tomographic scans. There are also animal studies (Nabili et al, 1999) demonstrating that ossifi cation occurs within the cochlea as early as 3 weeks after intrathecal injection of Streptococcus pneumoniae. Early diagnosis would allow early amplifi cation of hearing and 'fast tracking' of cochlear implantation where needed before severe ossifi cation occurs as this can make cochlear implantation much more diffi cult.…”

Section: Discussionmentioning

confidence: 99%

Meningitis resulting in hearing loss and labyrinthitis ossificans - does the causative organism matter?

Douglas¹,

Sanli²,

Gibson³

2008

Cochlear Implants Int.

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Section: Discussionmentioning

confidence: 99%

Meningitis resulting in hearing loss and labyrinthitis ossificans - does the causative organism matter?

Douglas¹,

Sanli²,

Gibson³

2008

Cochlear Implants Int.

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“…Clinically, patients have been described with heterotopic ossifications of cutaneous (18,19), intratendinous (20), pulmonary (21), and cochlear and vestibular lumenal (22) sites. Severe examples of dysregulated bone formation include myositis ossificans, a progressive ossification of striated muscle and faciitis (23), and fibrodysplasia ossificans progressiva, which refers to postnatal heterotopic ossification of connective tissue (24).…”

Section: Introductionmentioning

confidence: 99%

Expression of IL-5 alters bone metabolism and induces ossification of the spleen in transgenic mice

Macias¹,

Fitzpatrick²,

Brenneise³

et al. 2001

J. Clin. Invest.

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We have developed a transgenic mouse line, NJ.1638, which expresses high levels of IL-5 from T cells, with profound hematological consequences. Eosinophils comprise more than 60% of circulating white blood cells in these animals, with the total peripheral white blood cell counts increasing more than 40-fold relative to wild-type littermates. This extraordinary proliferative capacity is sustained by expanded sites of extramedullary hematopoiesis and is accompanied by multifocal, ectopic bone formation in the spleen. Histology of the splenic nodules revealed the presence of osteoid matrices and osteocytes trapped within mineralized trabecular plates. In addition, polarized light microscopy of calcified tissue sections revealed both woven bone and areas of organized lamellar bone. Morphometric assessments demonstrated that both the growth and mineralization of splenic bone occurred at rates nearly an order of magnitude higher than in skeletal bone. Skeletal bone metabolic parameters were also perturbed. We also observed heterotopic ossification of the spleen and perturbation of skeletal bone homeostasis following adoptive engraftment of transgenic marrow to wild-type recipients. These data suggest that IL-5 overexpression mediates bone formation through the mobilization of marrowderived osteogenic progenitors and/or the inhibition of recruited osteoclasts.

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“…Obliteration of the cochlear lumina is a major problem in survivors of meningitis, because it worsens the prognosis of cochlear implants. 17 Now, to test whether adjunctive antioxidant therapy is a promising strategy for the prevention of meningitis-induced hearing impairment, we assessed the effect of the two peroxynitrite scavengers Mn(III)tetrakis(4-bencoic acid)-porphyrin (MnTBAP) and N-acetyl-L-cysteine (NAC) in our well-established rat model of pneumococcal meningitis.…”

mentioning

confidence: 99%

Meningitis‐associated hearing loss: Protection by adjunctive antioxidant therapy

Klein

Koedel

Pfister

et al. 2003

Annals of Neurology

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Hearing loss is the most frequent long-term complication of pneumococcal meningitis, affecting up to 40% of survivors. Unfortunately, adjuvant therapy with dexamethasone has failed to satisfactorily reduce its incidence. Therefore, we evaluated the use of antioxidants for the adjunctive therapy of meningitis-associated deafness. Eighteen hours after intracisternal injection of 7.5 x 10(5) colony-forming units of Streptococcus pneumoniae, rats were treated systemically either with ceftriaxone and the antioxidants and peroxynitrite scavengers Mn(III)tetrakis(4-benzoic acid)-porphyrin (MnTBAP) or N-acetyl-L-cysteine (NAC) or placebo (1 ml phosphate-buffered saline) for 4 days. Hearing was assessed by auditory brainstem response audiometry. Adjunctive antioxidant therapy significantly reduced the long-term hearing loss (14 days after infection) for square wave impulses (mean hearing loss +/- SD: ceftriaxone and placebo, 45+/-26 dB; ceftriaxone and MnTBAP, 9+/-23 dB; ceftriaxone and NAC, 19+/-30 dB) as well as 1 kHz (ceftriaxone and placebo, 28+/-19 dB; ceftriaxone and MnTBAP, 10+/-16 dB; ceftriaxone and NAC, 10+/-17 dB), and 10 kHz tone bursts (ceftriaxone and placebo, 62+/-27 dB; ceftriaxone and MnTBAP, 16+/-13 dB; ceftriaxone and NAC, 25+/-26 dB). Furthermore, both antioxidants attenuated the morphological correlates of meningogenic hearing loss, namely, long-term blood-labyrinth barrier disruption, spiral ganglion neuronal loss, and fibrous obliteration of the perilymphatic spaces. Adjuvant antioxidant therapy is highly otoprotective in meningitis and therefore is a promising future treatment option.

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Chronology of labyrinthitis ossificans induced by streptococcus pneumoniae meningitis

Abstract: The use of fluorescent stains in this animal model provides a means to establish a timeline of the ossification seen in labyrinthitis ossificans.

Cited by 45 publications

References 18 publications

Meningitis resulting in hearing loss and labyrinthitis ossificans - does the causative organism matter?

Meningitis resulting in hearing loss and labyrinthitis ossificans - does the causative organism matter?

Expression of IL-5 alters bone metabolism and induces ossification of the spleen in transgenic mice

Meningitis‐associated hearing loss: Protection by adjunctive antioxidant therapy

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