Meningitis resulting in hearing loss and labyrinthitis ossificans - does the causative organism matter?

Douglas, Susan A; Sanli, Halit; Gibson, W. P. R.

doi:10.1002/cii.344

Cited by 17 publications

(16 citation statements)

References 13 publications

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“…This is in agreement with experimental studies on meningitis caused by S. pneumoniae, showing frequent occurrence of cochlear ossification [5]. In addition, S. pneumoniae is the bacterium most likely to cause post-meningitic hearing loss in humans [1,6] and temporal bone studies have shown a correlation between spiral ganglion neuron loss and the occurrence and degree of ossification [2]. We performed a semi-quantitation of the degree of ossification observed, which showed no difference between CT and MRI, between immediate and delayed cases, or between pediatric and adult cases.…”

Section: Discussionsupporting

confidence: 84%

Cochlear ossification in patients with profound hearing loss following bacterial meningitis

Cayé‐Thomasen

Dam

Omland

et al. 2012

Acta Oto-Laryngologica

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Cochlear ossification was observed in 35% of patients and 26% of ears on CT. The corresponding values for MRI were 44 and 30% (difference not significant). Streptococcus pneumoniae infection caused ossification more frequently than Neisseria meningitidis. No difference was found between pediatric and adult cases, and the occurrence of ossification was not related to the time point of evaluation. Signs of progressive ossification were found in cases with two CT scans, especially if ossification was present at the first scan.

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Section: Discussionsupporting

confidence: 84%

Cochlear ossification in patients with profound hearing loss following bacterial meningitis

Cayé‐Thomasen

Dam

Omland

et al. 2012

Acta Oto-Laryngologica

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“…Bacterial meningitis is a leading cause of acquired profound sensorineural hearing loss (SNHL), particularly in children. 1 Post meningitic hearing loss is frequently accompanied by an inflammatory process known as labyrinthitis ossificans. This process of intra cochlear ossification and fibrosis leads to obliteration of the scala tympani in the basal turn of the cochlea in up to 80% of post meningitic patients.…”

Section: Discussionmentioning

confidence: 99%

Electrode deactivation in post‐meningitic cochlear implant recipients

et al. 2011

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Objective:To assess the frequency of electrode deactivation over time in post meningitic cochlear implant (CI) recipients Study Design:Retrospective chart review Methods:A retrospective chart review of all post meningitic cochlear implant recipients at New York University from 1984 2008 was conducted. Patients with more than 2 years of follow up programming and speech perception data were included. Percent of active electrodes was calculated relative to maximum number of programmable electrodes. Frequency and pattern of electrode deactivation over time was analyzed and compared to published data on non meningitic CI patients Results:A total of 14 patients with 17 implanted ears were included. Length of follow up ranged from 2 25 years (average 7.3). A total of 9 (53%) ears experienced a reduction in active electrodes. Of these, 3 patients had deactivation of 1 electrode, 4 patients lost 2 electrodes, and the remaining 2 patients had had 5 and 6 electrodes deactivated, respectively. All patients except one had a minimum of 11 active electrodes at all times. Rate of deactivation over time was variable with loss of electrodes occurring up to 4 years post operatively. Three of the 9 ears with electrode deactivation received Nucleus 24 double array devices. Loss of electrodes was not correlated with a decline in speech perception, age at implantation or duration of deafness. There was one device failure. Conclusions:Deactivation of CI electrodes over time is common in post meningitic CI recipients (53%) and exceeds rates from non meningitic patients (1%.). Although electrode deactivation is multi factorial, anatomic considerations, such as ongoing compromise of the electrode neural interface by labyrinthitis ossificans, may contribute to deactivation in both the short and long term.A retrospective chart review of all post meningitic CI recipients at New York University from 1984 2008 was conducted. Patients with more than 2 years of follow up programming and speech perception data were included. Those with cochlear ossification resulting from processes other than meningitis, including otosclerosis, chronic otitis media, ototoxic agents, trauma or idiopathic processes were excluded. Maximum number of programmable electrodes were determined by type of device and number of electrodes inserted during implantation. Electrodes were deactivated for subjective complaints or for objective evidence of electrode malfunction. Number of deactivated electrodes following initial CI stimulation was recorded.The present study examined CI electrode deactivation over time in post meningitic CI recipients and found 9 of 17 ears (53%) with at least 1 deactivated electrode. This rate is higher than that found by previous authors in non meningitic populations. Zeitler et al (2008) found that 1% of CI recipients undergo 1 or more electrode deactivations following initial stimulation. Loss of 5 or more electrodes was correlated with device failure. 5 Carlson et al. (2010) found slightly higher rates 9% of patients in their study exp...

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“…Исследования пациентов с нейросенсорной тугоухостью, проведенные D.Philippon с соавторами в 2010 году с использованием компьютерной томографии височных костей (КТ), установили, что более выраженная степень оссификации улитки чаще определяется после перенесенного менингита, вызванного S.pneumоniaу [22]. Воздействие эндотоксина S.pneumоniae, N.meningitidis, H.influenzae и распространение инфекции во внутреннее ухо через водопровод улитки или внутренний слуховой проход приводит к тяжелой степени потери слуха (глухоте) на ранней стадии менингита [23,24].…”

Section: результаты и обсуждениеunclassified

“…Третья стадия нейросенсорной тугоухости завершается оссификацией. Оссификация улитки является патологическим формированием «новой кости» в просвете капсулы лабиринта, приводящей к стойкой потери слуха [24]. На стадии оссификации формируется костная ткань, которая в первую очередь обнаруживается в базальном завитке, начиная со второго месяца после развития лабиринтита.…”

Section: результаты и обсуждениеunclassified

Sensorineural hearing loss after bacterial meningitis in children

Seidullayeva

Zhaxylykova

Bayesheva³

et al. 2017

J CLIN MED KAZ

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Sensorineural hearing loss -form of hearing loss up to its total lossat which any of the sites of the sound-receiving part can be damaged. The most important problem of patients with sensorineural hearing loss is lack of effective treatment and inability to restore hearing because 80% of patients who suffered from bacterial meningitis loss of hearing is accompanied by ossification of internal ear structures. However, bacterial meningitis is still registered in Kazakhstan and is a reason of development of sensorineural hearing loss and often accompanied byossification of internal ear structures in children and adults leading to longterm neurological lesions, such as hearing impairments or hearing loss. For early diagnosis of hearing loss in children with bacterial meningitis, an audiological examination should be performed in the first 48 hours from the onset of the diseaseand after discharge from the hospital for 1 year. To date, the only effective method of hearing restoration is surgery -cochlear implantation. This review of the literature is devoted to one of the actual complications of bacterial meningitis -sensorineural deafness in children.Keywords: bacterial meningitis, sensorineural hearing loss, children, S.pneumoniae, H.influenzae, N.meningitidis. ТҰЖЫРЫМДАМАНейросенсорлық кереңдік-естуді қабылдайтын анализатордың қандай да бір бөлімінің зақымдалу әсерінен есту қабілетінің толық жоғалуы. Нейросенсорлық кереңдікпен сыртқаттанған науқастастардың негізгі мәселесі тиімді емнің болмауы және есту қабілетін қалыпқа келтірудің қиындығы болып табылады. Өйткені, бактериалдық менингитпен ауырған 80% науқастарда естудің жоғалуы ішкі құлақ осси-фикациясымен байқалады. Бірақ, Қазақстанда бактериалдық менингит аурушаңдылығы әлі де тіркеледі және балалар мен ересектерде нейросенсорлық кереңдіктің себебі болып табылады, сонымен қатар ұзақ мерзімді есту қабілетінің төмендеуі немесе естудің жоғалуы сияқты неврологиялық асқынуларға алып келеді. Балалардағы бактериалдық менингиттен кейінгі есту қабілетінің жоғалуын ерте анықтау үшін, аурудың басталуынан бастап алғашқы 48 сағатта және ауруханадан емделіп шыққаннан кейін 1 жыл ішінде аудиологиялық тексе-ру жүргізу қажет. Қазіргі таңда естуді қалпына келтірудің ең тиімді әдісі ота арқылы -кохлеарлы имплантацияны жасау болып табылады. Берілген әдебиетке шолуда балалардағы бактериальдық менингиттен кейінгі негізгі асқынулардың бірі нейросенсорлықкереңдікке арналған.Маңызды сөздер: бактериалдық менингит, нейросенсорлық кереңдік, балалар, пневмококк, гемофилдік таяқша, менингококк. .

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Meningitis resulting in hearing loss and labyrinthitis ossificans - does the causative organism matter?

Cited by 17 publications

References 13 publications

Cochlear ossification in patients with profound hearing loss following bacterial meningitis

Cochlear ossification in patients with profound hearing loss following bacterial meningitis

Electrode deactivation in post‐meningitic cochlear implant recipients

Sensorineural hearing loss after bacterial meningitis in children

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