Abstract:Hypertension shows circadian blood pressure rhythms (day-night pattern) that urge the delivery of antihypertensive drugs at the right time in the desired levels. Thus, a bilayered core-in-cup buccoadhesive tablet was formulated that immediately releases olmesartan, to give a burst effect, and controls azelnidipine release, to prolong its therapeutic effect. The main challenge was the poor bioavailability of azelnidipine due to its poor aqueous solubility and first-pass effect. Hence, liquisolid compact buccoad… Show more
“…An in vivo pharmacokinetic study in healthy human volunteers was conducted with an immediate release commercially available tablet as a control. Olmesartan was rapidly absorbed and reached higher maximum plasma concentration (Cmax) than the control, while azelnidipine showed a prolonged release profile with a significant increase in the extent of absorption (60).…”
Section: Development Of Modified Release Preparationsmentioning
Liquisolid systems are a novel, promising platform for the production of solid dosage forms with a high liquid content, i.e. dispersion of the drug in a suitable, hydrophilic, non-volatile liquid vehicle or liquid drug. This technology requires conventional, but highly porous excipients (carrier and coating material in the appropriate ratio) able to absorb/adsorb liquid medication, resulting in both good flowability and acceptable compression properties. This approach has shown great potential to improve the dissolution rate and bioavailability of poorly soluble drugs, and has been recognized as a good alternative to common, more complex and expensive techniques. A variety of applications of this simple technique have been investigated recently, including the preparation of: modified release tablets, orally disintegrating tablets, solid dosage forms with liquid herbal extracts, etc. This emerging technology has numerous advantages, and the most important are: simplicity, cost-effectiveness, applicability in large scale production and environmental friendliness. However, it is accompanied by certain challenges as well, such as limited applicability in the case of highly dosed drugs. This article aims to give a comprehensive overview of recent progress regarding the potential applications of this technology, as well as to give an insight into the new liquisolid-based techniques intending to further support its commercial applicability.
“…An in vivo pharmacokinetic study in healthy human volunteers was conducted with an immediate release commercially available tablet as a control. Olmesartan was rapidly absorbed and reached higher maximum plasma concentration (Cmax) than the control, while azelnidipine showed a prolonged release profile with a significant increase in the extent of absorption (60).…”
Section: Development Of Modified Release Preparationsmentioning
Liquisolid systems are a novel, promising platform for the production of solid dosage forms with a high liquid content, i.e. dispersion of the drug in a suitable, hydrophilic, non-volatile liquid vehicle or liquid drug. This technology requires conventional, but highly porous excipients (carrier and coating material in the appropriate ratio) able to absorb/adsorb liquid medication, resulting in both good flowability and acceptable compression properties. This approach has shown great potential to improve the dissolution rate and bioavailability of poorly soluble drugs, and has been recognized as a good alternative to common, more complex and expensive techniques. A variety of applications of this simple technique have been investigated recently, including the preparation of: modified release tablets, orally disintegrating tablets, solid dosage forms with liquid herbal extracts, etc. This emerging technology has numerous advantages, and the most important are: simplicity, cost-effectiveness, applicability in large scale production and environmental friendliness. However, it is accompanied by certain challenges as well, such as limited applicability in the case of highly dosed drugs. This article aims to give a comprehensive overview of recent progress regarding the potential applications of this technology, as well as to give an insight into the new liquisolid-based techniques intending to further support its commercial applicability.
This study aims to facilitate and speed up the process of ordering menus in restaurants by customers and minimize the usual errors when ordering. In designing applications, we used descriptive method to see what processes must and can be done so customers can place orders easily and quickly. From this research, an application is produced which will make it easier for customers to make the order process, besides that the ordering process can be done quickly. This result is obtained because the application is designed to have an easy-to-understand flow for customers in order. The ordering process is faster because customers no longer need to ask and wait for the restaurant waiter to serve the order process. By facilitating and speeding up the ordering process, a restaurant will make visitors from restaurants feel comfortable and well served so that the restaurant business will run better.
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