Chronobiological Aspects of Sleep Disorders in Menopausal Women: The Role of Melatonin (Literature Review)

Семёнова, Н. В.; Semyonova, N. V.

doi:10.12737/article_59e71aad2aa777.29348772

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…В настоящее время доказана важная роль мелатонина в работе антиоксидантных систем организма за счёт захвата свободных радикалов кислорода и гидроксила кольцом пиррола мелатонина, а также участия гормона в экспрессии генов глутатионпероксидазы, глутатионредуктазы, супероксиддисмутазы и каталазы и повышения ферментативной активности в фармакологических и физиологических дозах [24]. Большую часть времени кишечник адекватно реагирует на окислительный стресс, но с возрастом или в условиях, усугубляющих продукцию активных форм кислорода и/или активных форм азота, защитных сил недостаточно, что способствуют развитию заболеваний [25,26], в том числе кишечной патологии [27,28]. Исследования в данном направлении актуальны, однако малочисленны.…”

Section: мелатонин: синтез метаболизм эффектыunclassified

Melatonin and gut microbiome

Garashchenko,

Semenova,

Kolesnikova

2024

Acta biomedica scientifica

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In recent years, studies of the human microbiome have led to the development of the gut-brain axis theory, which proposes a relationship between the gut bacterial community and its metabolites and chemical compounds, as well as physiological and pathological processes in the brain. Melatonin is considered one of the potential links in this relationship.The review provides brief information about the synthesis, metabolism and effects of melatonin in the body. General patterns of the effect of melatonin on the intestinal microbiota under various conditions, such as oral and intraperitoneal melatonin administration, sleep deprivation, as well as the results of studying the microbial community with measurement of hormone levels are considered.Results are presented for families and individual genera of microorganisms and are obtained from studies in animal models or in the research of diseases. The article also notes some additional parameters which are supposed to be relevant to the interaction of melatonin with gut microbiome. Special attention is paid to butyrate as one of the most studied possible parts in this interaction. Studying the relationship between melatonin and microbiome is of interest for basic science and practical medicine.Literature search was carried out using electronic information resources PubMed and eLibrary.

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Section: мелатонин: синтез метаболизм эффектыunclassified

Melatonin and gut microbiome

Garashchenko,

Semenova,

Kolesnikova

2024

Acta biomedica scientifica

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Polymorphism of genes of circadian rhythms in employees of a continuous production enterprise with a shift work schedule

Subbotina

Dolgikh

2023

Med. tr. prom. èkol.

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The circadian system plays an important role in regulating the functions of the human body. As a result of violations of the circadian system, functional disorders such as sleep disorders, carbohydrate metabolism, metabolic syndrome turning into obesity, cardiovascular pathology, oncological processes occur. One of the socially significant causes of circadian rhythm disorders is a shift work schedule. The study aims to explore the genetic status of employees and identify markers of predisposition to the formation of "intolerance" of shift work. Researchers have examined two groups of employees of the enterprise: observation group — 40 people gave 23–63 years old (30 women, 10 men) with a shift work schedule, the comparison group consisted of 51 people 24–62 years old (41 women, 10 men) of the administrative apparatus with a daily work schedule. Typing of polymorphic loci of the circadian system genes was carried out by sets of the company "Syntol" (Russia) using the Real-Time PCR method on a CFX96 device with allelic discrimination of fluorescence curves. Genotyping of the loci of the five main circadian genes allowed us to establish that the occurrence of the minor allele T of the MTNR1A melatonin receptor gene (rs34532313) in continuous production workers is 30%, which is five times higher than in workers with a standardized work schedule (p<0.05). At the same time, workers with a shift schedule had a significant hypo-expression of serum serotonin (1.54 times, p<0.05) relative to the comparison group. Continuous production workers have an increased occurrence of the minor allele of the MTNR1A melatonin receptor T gene (rs34532313) with a simultaneous decrease in the expression of serotonin catecholamine, which in shift work conditions can affect the formation of dysregulatory disorders of the functioning of homeostatic systems and the course of physiological metabolic processes. As a result, the polymorphism of the MTNR1A gene (rs34532313) can use as a marker of "intolerance" to shift work. Limitations. There are quantitative restrictions on the observation group of persons of different genders. Ethics. When conducting the study, the authors were guided by the Ethical principles of conducting medical research with the participation of a person as a subject, set out in the Helsinki Declaration of the World Medical Association of the last revision. The patients signed a voluntary informed consent for the examination.

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Chronobiological Aspects of Sleep Disorders in Menopausal Women: The Role of Melatonin (Literature Review)

Cited by 2 publications

References 30 publications

Melatonin and gut microbiome

Melatonin and gut microbiome

Polymorphism of genes of circadian rhythms in employees of a continuous production enterprise with a shift work schedule

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